Shorter3: Litter size and composition in a diallel of Collaborative Cross founder strains (2018)

Shorter JR, Maurizio PL, Valdar W, Pardo-Manuel de Villena F   With: Bell TA, Shaw GD, Miller DR, Gooch TJ, Spence JS, McMillan L

       
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Participants John R Shorter       University of North Carolina Chapel Hill, NC
Paul L Maurizio       University of Chicago Chicago, IL
William Valdar       University of North Carolina Chapel Hill, NC
Fernando Pardo-Manuel de Villena       University of North Carolina Chapel Hill, NC
With: Bell TA, Shaw GD, Miller DR, Gooch TJ, Spence JS, McMillan L
ContactFernando Pardo-Manuel de Villena     fernando@med.unc.edu     Lab web site
AcknowledgementsFunding provided by NIH GM076468, HG006582, MH090338, HD065024, AI100625, AI007419, GM104125, GM127000; University Cancer Research Funds granted to Lineberger Comprehensive Cancer Center (MCR012CCRI)
Project type Phenotype strain survey data set
MPD identifiersShorter3     MPD:623
Data changelog No updates/corrections.       Initial release date: 10/2018.
Formatted citation
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Reproductive ability was investigated across the eight founders of the Collaborative Cross to better understand genetic and non-genetic factors that affect their fertility and breeding. Using an 8 x 8 diallel design, weaned litter sizes were measured from over 4400 litters arising from 62 crosses. Note that the unit of analysis is 'litter' (not individual dam), and sex of each litter was arbitrarily assigned female, resulting in plots that may incorrectly show females.

Summary of procedures that were conducted
• colony observation Litter size assessment.
Mice: CC diallel w/par   62 strains   ♀   age 3wks   1 cohort