Shorter3: Litter size and composition in a diallel of Collaborative Cross founder strains (2018)
Shorter JR, Maurizio PL, Bell TA, Shaw GD, Miller DR, Gooch TJ, Spence JS, McMillan L, Valdar W, Pardo-Manuel de Villena F. A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size.
G3 (Bethesda). 2019 Mar 15. pii: g3.200847.2018. doi: 10.1534/g3.118.200847. [Epub ahead of print]
Reproductive ability was investigated across the eight founders of the Collaborative Cross to better understand genetic and non-genetic factors that affect their fertility and breeding. Using an 8 x 8 diallel design, weaned litter sizes were measured from over 4400 litters arising from 62 crosses. Note that the unit of analysis is 'litter' (not individual dam), and sex of each litter was arbitrarily assigned female, resulting in plots that may incorrectly show females.
Procedures conducted:
Procedures conducted:
| Litter size assessment. |
Shorter3 downloads
• Download Shorter3 project data set animal data, as uploaded
• Download Shorter3 animal data matrix with factor-related expansion applied as necessary
• Download Shorter3 strain means, SD, N, etc. one row per strain/sex/measure
• Download Shorter3 project data set animal data, as uploaded
• Download Shorter3 animal data matrix with factor-related expansion applied as necessary
• Download Shorter3 strain means, SD, N, etc. one row per strain/sex/measure
Ontology terms mapped to Shorter3 measures:
| Investigators |
John R Shorter University of North Carolina, Chapel Hill, NC Paul L Maurizio University of Chicago, Chicago, IL William Valdar University of North Carolina, Chapel Hill, NC Fernando Pardo-Manuel de Villena University of North Carolina, Chapel Hill, NC |
| Participants | Bell TA, Shaw GD, Miller DR, Gooch TJ, Spence JS, McMillan L |
| Contact | Fernando Pardo-Manuel de Villena fernando@med.unc.edu
|
| Acknowledgements | Funding provided by NIH GM076468, HG006582, MH090338, HD065024, AI100625, AI007419, GM104125, GM127000; University Cancer Research Funds granted to Lineberger Comprehensive Cancer Center (MCR012CCRI) |
| Phenotype strain survey data set | |
| MPD identifiers | Shorter3 MPD:623 |
| No updates/corrections. Initial release date: 10/2018. | |
|
Click above to copy-paste the entire citation for this MPD web page. |
