Shorter3: Litter size and composition in a diallel of Collaborative Cross founder strains (2018)

Shorter JR, Maurizio PL, Bell TA, Shaw GD, Miller DR, Gooch TJ, Spence JS, McMillan L, Valdar W, Pardo-Manuel de Villena F. A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size. G3 (Bethesda). 2019 Mar 15. pii: g3.200847.2018. doi: 10.1534/g3.118.200847. [Epub ahead of print]   PubMed 30877080  

Shorter3 downloads
• Download Shorter3 project data set     animal data, as uploaded
• Download Shorter3 animal data matrix     with factor-related expansion applied as necessary
• Download Shorter3 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators John R Shorter       University of North Carolina,  Chapel Hill, NC
Paul L Maurizio       University of Chicago,  Chicago, IL
William Valdar       University of North Carolina,  Chapel Hill, NC
Fernando Pardo-Manuel de Villena       University of North Carolina,  Chapel Hill, NC
Participants Bell TA, Shaw GD, Miller DR, Gooch TJ, Spence JS, McMillan L
ContactFernando Pardo-Manuel de Villena     Lab web site
AcknowledgementsFunding provided by NIH GM076468, HG006582, MH090338, HD065024, AI100625, AI007419, GM104125, GM127000; University Cancer Research Funds granted to Lineberger Comprehensive Cancer Center (MCR012CCRI)
Project type Phenotype strain survey data set
MPD identifiersShorter3     MPD:623
Data changelog No updates/corrections.       Initial release date: 10/2018.
Formatted citation
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Reproductive ability was investigated across the eight founders of the Collaborative Cross to better understand genetic and non-genetic factors that affect their fertility and breeding. Using an 8 x 8 diallel design, weaned litter sizes were measured from over 4400 litters arising from 62 crosses. Note that the unit of analysis is 'litter' (not individual dam), and sex of each litter was arbitrarily assigned female, resulting in plots that may incorrectly show females.

Procedures conducted:
• colony observation  Litter size assessment.

Mice: CC diallel w/par   62 strains   ♀   age 3wks   1 experimental group