MPD: Data set: Zaytseva2

Krištić J, Zaytseva OO, Ram R, Nguyen Q, Novokmet M, Vučković F, Vilaj M, Trbojević-Akmačić I, Pezer M, Davern KM, Morahan G, Lauc G. Profiling and genetic control of the murine immunoglobulin G glycome. Nat Chem Biol. 2018 May;14(5):516-524. doi: 10.1038/s41589-018-0034-3. Epub 2018 Apr 9. PubMed 29632412

The immunoglobulin IgG glycome was characterized in Collaborative Cross strains originating at Geniad. This project contains data for N-glycan profiles of IgG subclasses in 95 CC strains and Zaytseva1 contains data for glycan levels in 111 CC strains.

Procedures conducted:

• glycosylation profile

IgG subclasses, relative abundance

Zaytseva2 downloads
• Download Zaytseva2 project data set animal data, as uploaded
• Download Zaytseva2 project data set animal data, as uploaded
• Download Zaytseva2 animal data matrix with factor-related expansion applied as necessary
• Download Zaytseva2 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Zaytseva2 measures:

Investigators	Olga O Zaytseva Glycoscience Research Laboratory, Genos Ltd, Zagreb CROATIA Jasminka Krištić Glycoscience Research Laboratory, Genos Ltd, Zagreb CROATIA Grant Morahan Harry Perkins Institute of Medical Research, Nedlands, Western Australia AUSTRALIA Gordan Lauc University of Zagreb, Zagreb CROATIA
Participants	Ram R, Nguyen Q, Novokmet M, Vučković F, Vilaj M, Trbojević-Akmačić I, Pezer M, Davern KM
Contact	Gordan Lauc glauc@pharma.hr Lab web site
Acknowledgements	Funding provided by WA Diabetes Research Foundation, Program 1037321; National Health and Medical Research Council of Australia, Project 1069173; European Commission FP7 grants MIMOmics, contract 305280, H2020 projects GlySign contract 722095, IMforFuture contract 721815; European Structural and Investment Funds IRI grant KK.01.2.1.01.0003; Croatian National Centre of Research Excellence in Personalized Healthcare grant KK.01.1.1.01.0010.
Project type	Phenotype strain survey data set
MPD identifiers	Zaytseva2 MPD:652
Data changelog	No updates/corrections. Initial release date: 10/2019.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)

Zaytseva2:1	Zaytseva2	glycosylation profile	(none)	IgG1 with bisected N-acetylglucosamine N-glycan structures (relative abundance) [%] mIgG1_B 110032	CC	94	both	20-117wks	N=2

Zaytseva2:2	Zaytseva2	glycosylation profile	(none)	IgG1 with galactosylated N-glycan structures (relative abundance) [%] mIgG1_G 110033	CC	94	both	20-117wks	N=2

Zaytseva2:3	Zaytseva2	glycosylation profile	(none)	IgG1 with agalactosylated N-glycan structures (relative abundance) [%] mIgG1_G0 110034	CC	94	both	20-117wks	N=2

Zaytseva2:4	Zaytseva2	glycosylation profile	(none)	IgG1 with monogalactosylated N-glycan structures (relative abundance) [%] mIgG1_G1 110035	CC	94	both	20-117wks	N=2

Zaytseva2:5	Zaytseva2	glycosylation profile	(none)	IgG1 with digalactosylated N-glycan structures (relative abundance) [%] mIgG1_G2 110036	CC	94	both	20-117wks	N=2

Zaytseva2:6	Zaytseva2	glycosylation profile	(none)	IgG1 with sialylated N-glycan structures (relative abundance) [%] mIgG1_S 110037	CC	94	both	20-117wks	N=2

Zaytseva2:7	Zaytseva2	glycosylation profile	(none)	IgG1 with monosialylated N-glycan structures (relative abundance) [%] mIgG1_S1 110038	CC	94	both	20-117wks	N=2

Zaytseva2:8	Zaytseva2	glycosylation profile	(none)	IgG1 with disialylated N-glycan structures (relative abundance) [%] mIgG1_S2 110039	CC	94	both	20-117wks	N=2

Zaytseva2:9	Zaytseva2	glycosylation profile	(none)	IgG1 with alpha1,3-linked galactose residue N-glycan structures (relative abundance) [%] mIgG1_aGal 110040	CC	94	both	20-117wks	N=2

Zaytseva2:10	Zaytseva2	glycosylation profile	(none)	IgG2 with bisected N-acetylglucosamine N-glycan structures (relative abundance) [%] mIgG2_B 110041	CC	94	both	20-117wks	N=2

Zaytseva2:11	Zaytseva2	glycosylation profile	(none)	IgG2 with galactosylated N-glycan structures (relative abundance) [%] mIgG2_G 110042	CC	94	both	20-117wks	N=2

Zaytseva2:12	Zaytseva2	glycosylation profile	(none)	IgG2 with agalactosylated N-glycan structures (relative abundance) [%] mIgG2_G0 110043	CC	94	both	20-117wks	N=2

Zaytseva2:13	Zaytseva2	glycosylation profile	(none)	IgG2 with monogalactosylated N-glycan structures (relative abundance) [%] mIgG2_G1 110044	CC	94	both	20-117wks	N=2

Zaytseva2:14	Zaytseva2	glycosylation profile	(none)	IgG2 with digalactosylated N-glycan structures (relative abundance) [%] mIgG2_G2 110045	CC	94	both	20-117wks	N=2

Zaytseva2:15	Zaytseva2	glycosylation profile	(none)	IgG2 with sialylated N-glycan structures (relative abundance) [%] mIgG2_S 110046	CC	94	both	20-117wks	N=2

Zaytseva2:16	Zaytseva2	glycosylation profile	(none)	IgG2 with monosialylated N-glycan structures (relative abundance) [%] mIgG2_S1 110047	CC	94	both	20-117wks	N=2

Zaytseva2:17	Zaytseva2	glycosylation profile	(none)	IgG2 with disialylated N-glycan structures (relative abundance) [%] mIgG2_S2 110048	CC	94	both	20-117wks	N=2

Zaytseva2:18	Zaytseva2	glycosylation profile	(none)	IgG2 with alpha1,3-linked galactose residue N-glycan structures (relative abundance) [%] mIgG2_aGal 110049	CC	94	both	20-117wks	N=2

Zaytseva2:19	Zaytseva2	glycosylation profile	(none)	IgG3 with bisected N-acetylglucosamine N-glycan structures (relative abundance) [%] mIgG3_B 110050	CC	95	both	20-117wks	N=2

Zaytseva2:20	Zaytseva2	glycosylation profile	(none)	IgG3 with galactosylated N-glycan structures (relative abundance) [%] mIgG3_G 110051	CC	95	both	20-117wks	N=2

Zaytseva2:21	Zaytseva2	glycosylation profile	(none)	IgG3 with agalactosylated N-glycan structures (relative abundance) [%] mIgG3_G0 110052	CC	95	both	20-117wks	N=2

Zaytseva2:22	Zaytseva2	glycosylation profile	(none)	IgG3 with monogalactosylated N-glycan structures (relative abundance) [%] mIgG3_G1 110053	CC	95	both	20-117wks	N=2

Zaytseva2:23	Zaytseva2	glycosylation profile	(none)	IgG3 with digalactosylated N-glycan structures (relative abundance) [%] mIgG3_G2 110054	CC	95	both	20-117wks	N=2

Zaytseva2:24	Zaytseva2	glycosylation profile	(none)	IgG3 with sialylated N-glycan structures (relative abundance) [%] mIgG3_S 110055	CC	95	both	20-117wks	N=2

Zaytseva2:25	Zaytseva2	glycosylation profile	(none)	IgG3 with monosialylated N-glycan structures (relative abundance) [%] mIgG3_S1 110056	CC	95	both	20-117wks	N=2

Zaytseva2:26	Zaytseva2	glycosylation profile	(none)	IgG3 with disialylated N-glycan structures (relative abundance) [%] mIgG3_S2 110057	CC	95	both	20-117wks	N=2

Zaytseva2:27	Zaytseva2	glycosylation profile	(none)	IgG3 with alpha1,3-linked galactose residue N-glycan structures (relative abundance) [%] mIgG3_aGal 110058	CC	95	both	20-117wks	N=2

Zaytseva2: IgG glycome: N-glycan profiles of IgG subclasses in 95 Collaborative Cross strains of mice (2018)