Miller RA, Harrison DE, Cortopassi GA, Dehghan I, Fernandez E, Garratt M, Geisler JG, Ginsburg BC, Han ML, Kaczorowski CC, Kumar N, Leiser SF, Lopez-Cruzan M, Milne G, Mitchell JR, Nelson JF, Reifsnyder PC, Salmon AB, Korstanje R, Rosenthal N, Strong R. Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin.
Geroscience. 2024 Oct;46(5):4657-4670. doi: 10.1007/s11357-024-01176-2. Epub 2024 May 16.
| Investigators |
Richard A Miller University of Michigan, Ann Arbor, MI Randy Strong University of Texas Health Science Center, San Antonio, TX Ron Korstanje The Jackson Laboratory, Bar Harbor, ME David E Harrison The Jackson Laboratory, Bar Harbor, ME Nadia A Rosenthal The Jackson Laboratory, Bar Harbor, ME |
| Contact | Richard A Miller millerr@umich.edu
|
| Affiliated Center | National Institute on Aging Interventions Testing Program (ITP) |
| Acknowledgements | Funding provided by NIH AG022303, AG022307, AG022308, AG066346 |
| Phenotype strain survey data set | |
| MPD identifiers | ITP2020 MPD:1222 |
| No updates/corrections. Initial release date: 03/2025. | |
|
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| Compound name and |
Year cohort |
Dose in food | Age at initiation | Compound's effect on lifespan* |
Other phenotypes | Ref# |
|---|---|---|---|---|---|---|
| 16-a-hydroxyestriol |
C2020 | 5 ppm | 12 mo | males p = 0.0004 |
[19] | |
| 2,4-dinitrophenol |
C2020 | 3 ppm | 6 mo | [19] | ||
| a-Ketoglutarate |
C2020 | 20,000 ppm | 18 mo | [19] | ||
| canagliflozin |
C2020 | 180 ppm | 6 or 16 mo | males 6 mo p = 0.0209 males 16 mo p = 0.023 |
[19] | |
| Hydralazine |
C2020 | 30 ppm | 6 or 16 mo | [19] | ||
| Nebivolol |
C2020 | 60 ppm | 6 mo | [19] | ||
| Sodium thiosulfate |
C2020 | 10,000 ppm | 6 mo | [19] |
* Log-rank test p-value on treated vs. control, shown when p ≤ 0.05 for each sex separately. Statistical definitions