HMDPpheno11: Diet effects on aortic lesion size in 103 Hybrid Mouse Diversity Panel strains that are transgenic for human APOE*3Leiden and human CETP (F1 hybrids) (2015)

Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet. 2015 Dec;11(12):e1005711. doi: 10.1371/journal.pgen.1005711. Epub 2015 Dec 22.   PubMed 26694027     FullText


         
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Investigators Brian J Bennett       University of North Carolina,  Chapel Hill, NC
Aldons J Lusis       University of California, Los Angeles,  Los Angeles, CA
Participants Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS
ContactAldons J Lusis     jlusis@mednet.ucla.edu     Lab web site
Affiliated CenterHybrid Mouse Diversity Panel Group (HMDP)
AcknowledgementsMice carrying the human ApoE3 Leiden variant were kindly provided by Dr. L. Havekes, Leiden University Medical Center, Leiden, Netherlands
Funding Provided ByFunding provided by NIH HL103866, HL113452, HL30568, HL28481, HL102223, HL121172; Transatlantic Networks of Excellence Award (12CVD03) from Foundation Leducq
Project type Phenotype strain survey data set
MPD identifiersHMDPpheno11     MPD:1013
Data changelog No updates/corrections.       Initial release date: 01/2020.
Formatted citation
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Male C57BL/6J mice carrying the dominant human transgenes for ApoE*3 Leiden variant and CETP were crossed with females of approximately 100 inbred strains from the Hybrid Mouse Diversity Panel (HDMP). At the age of 8 weeks, F1 progeny carrying both transgenes were placed on a high-fat diet supplemented with 1.0% cholesterol. Test mice were euthanized at approximately 24 weeks of age, and the lesion area in the proximal aorta was assessed.

Summary of procedures that were conducted
• histopathology Aortic lesion size after 16 wks on high-fat diet.
Mice: HMDP hAPOE and hCETP transgenic   103 strains   ♀♂   age 23-25 wks   1 experimental group (high-fat high-cholesterol diet)