GMC05: Acoustic startle response and prepulse inhibition in 8 inbred founder strains of the Collaborative Cross (2020)

German Mouse Clinic and Department of Infection Genetics, HZI   GMC Management Team   With: Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Garrett L, Hölter-Koch S, Wurst W, Lengger C, Kollmus H, Schughart K

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Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Garrett L, Hölter-Koch S, Wurst W, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     coregmc@helmholtz-muenchen.de     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC05     MPD:554
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
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The acoustic startle response (ASR) is characterized by an exaggerated flinching response to an unexpected strong auditory stimulus (pulse). This response can be attenuated when it is preceded by a weaker stimulus (pre-pulse) and is the principle underlying pre-pulse inhibition (PPI). PPI has been described in numerous species, including mice and humans and provides an operational measure of sensorimotor gating reflecting the ability of an animal to successfully integrate and inhibit sensory information. Several clinical studies have shown that a number of human disorders have impaired PPI including: schizophrenia, Huntington’s disease, fragile X syndrome, and autism.

Summary of procedures that were conducted
• acoustic startle test Acoustic startle response, prepulse inhibition.
Mice: inbred w/CC8   8 strains   ♀♂   age 9-10wks   5 experimental groups