Lesage2: Germinal center response in 68 genetically diverse inbred mouse strains of the Collaborative Cross and 8 founder strains (2024)
Collin R, Balmer L, Morahan G, Lesage S. Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross.
J Immunol. 2019 Feb 1;202(3):777-786. doi: 10.4049/jimmunol.1801247. Epub 2018 Dec 26.
Aubin AM, Vdovenko D, Collin R, Balmer L, Coderre L, Morahan G, Lombard-Vadnais F, Lesage S. Variations in the germinal center response revealed by genetically diverse mouse strains.
Immunol Cell Biol. 2024 Nov;102(10):935-948. doi: 10.1111/imcb.12823. Epub 2024 Sep 24.
Collaborative Cross mice were provided by Geniad Pty Ltd and bred at the Animal Resource Centre (Australia, WA, Perth). Where possible, standard CC strain nomenclature is used. The download file contains strain aliases. Collaborative Cross founder strains were obtained from The Jackson Laboratory and analyzed separately from the CC strains at the Maisonneuve-Rosemont Hospital Research Center (Montreal, Quebec, Canada). Data for Lesage1 and Lesage2 were collected at the same time. Lesage1 contains populations of NK cells, NK T cells, T cells, and dendritic cells while Lesage2 contains data about B cells.
Procedures conducted:
Procedures conducted:
| total number of splenocytes, number of B cells in spleen, and percentage of splenocytes that are B cells |
Lesage2 downloads
• Download Lesage2 project data set animal data, as uploaded
• Download Lesage2 animal data matrix with factor-related expansion applied as necessary
• Download Lesage2 strain means, SD, N, etc. one row per strain/sex/measure
• Download Lesage2 supplementary file, ICB_08_2024_supplemental_table_1_MPD_withMouseID_V2.xlsx Original submission
• Download Lesage2 project data set animal data, as uploaded
• Download Lesage2 animal data matrix with factor-related expansion applied as necessary
• Download Lesage2 strain means, SD, N, etc. one row per strain/sex/measure
• Download Lesage2 supplementary file, ICB_08_2024_supplemental_table_1_MPD_withMouseID_V2.xlsx Original submission
Ontology terms mapped to Lesage2 measures:
| Investigators |
Sylvie Lesage University of Montreal, Montreal, Quebec CANADA Roxanne Collin University of Montreal, Montreal, Quebec CANADA Lois Balmer Harry Perkins Institute of Medical Research, Nedlands, Western Australia AUSTRALIA Grant Morahan Harry Perkins Institute of Medical Research, Nedlands, Western Australia AUSTRALIA |
| Contact | Sylvie Lesage sylvie.lesage@umontreal.ca
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| Phenotype strain survey data set | |
| MPD identifiers | Lesage2 MPD:1215 |
| No updates/corrections. Initial release date: 11/2024. | |
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