Lesage2: Germinal center response in 68 genetically diverse inbred mouse strains of the Collaborative Cross and 8 founder strains (2024)

Collin R, Balmer L, Morahan G, Lesage S. Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross. J Immunol. 2019 Feb 1;202(3):777-786. doi: 10.4049/jimmunol.1801247. Epub 2018 Dec 26.   PubMed 30587532  

Aubin AM, Vdovenko D, Collin R, Balmer L, Coderre L, Morahan G, Lombard-Vadnais F, Lesage S. Variations in the germinal center response revealed by genetically diverse mouse strains. Immunol Cell Biol. 2024 Nov;102(10):935-948. doi: 10.1111/imcb.12823. Epub 2024 Sep 24.   PubMed 39318030  


         
Collaborative Cross mice were provided by Geniad Pty Ltd and bred at the Animal Resource Centre (Australia, WA, Perth). Where possible, standard CC strain nomenclature is used. The download file contains strain aliases. Collaborative Cross founder strains were obtained from The Jackson Laboratory and analyzed separately from the CC strains at the Maisonneuve-Rosemont Hospital Research Center (Montreal, Quebec, Canada). Data for Lesage1 and Lesage2 were collected at the same time. Lesage1 contains populations of NK cells, NK T cells, T cells, and dendritic cells while Lesage2 contains data about B cells.

Procedures conducted:
• immune cell quantification  total number of splenocytes, number of B cells in spleen, and percentage of splenocytes that are B cells

Lesage2 downloads
• Download Lesage2 project data set     animal data, as uploaded
• Download Lesage2 animal data matrix     with factor-related expansion applied as necessary
• Download Lesage2 strain means, SD, N, etc.     one row per strain/sex/measure
• Download Lesage2 supplementary file, ICB_08_2024_supplemental_table_1_MPD_withMouseID_V2.xlsx     Original submission
Investigators Sylvie Lesage       University of Montreal,  Montreal, Quebec CANADA
Roxanne Collin       University of Montreal,  Montreal, Quebec CANADA
Lois Balmer       Harry Perkins Institute of Medical Research,  Nedlands, Western Australia AUSTRALIA
Grant Morahan       Harry Perkins Institute of Medical Research,  Nedlands, Western Australia AUSTRALIA
ContactSylvie Lesage     sylvie.lesage@umontreal.ca     Lab web site
Project type Phenotype strain survey data set
MPD identifiersLesage2     MPD:1215
Data changelog No updates/corrections.       Initial release date: 11/2024.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice: CC w/par   76 strains   ♀♂   age 5-8wks   1 experimental group

Sort/
Pick
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Lesage2 immune cell quantification (none) total number of splenic lymphocytes (x 106)   [n]  spleen_cells_tot   131924     CC w/par 76 both 5-8wks N=2
    Lesage2 immune cell quantification (none) number of B cells in spleen (x 106)   [n]  B_cells_tot   131925     CC w/par 76 both 5-8wks N=2
    Lesage2 immune cell quantification (none) percentage of splenic lymphocytes that are B cells (CD3-CD49b-B220+CD19+)   [%]  B_cells_pct   131926     CC w/par 76 both 5-8wks N=2
    All boxes            


  •   Or, add these measures to your collection.
       
  •     no folder
  •     put them in new folder