GMC18: Bone mineral density, body composition, and X-ray analysis of 8 inbred founder strains of the Collaborative Cross (2020)

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14.   PubMed 32060626     FullText


          List all GMC measures
Experimental groups in this study:
• None     • None     • None     • None     • None    

Procedures conducted:
• body size and weight  Body weight and length.
• DXA  Body mass, fat mass, lean mass, bone mineral density and content, bone area.
• X-ray  Lumbar vertebrae count.

GMC18 downloads
• Download GMC18 project data set     animal data, as uploaded
• Download GMC18 animal data matrix     with factor-related expansion applied as necessary
• Download GMC18 strain means, SD, N, etc.     one row per strain/sex/measure
• GMC18 supplementary data
Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Mayer-Kuckuk P, Hans W, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     coregmc@helmholtz-muenchen.de     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC18     MPD:567
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice: inbred w/CC8   8 strains   ♀♂   age 17-18wks   5 experimental groups

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    GMC18 body size and weight (none) body weight   [g]  bw   56701 inbred w/CC8 8 both 17-18wks N=12
    GMC18 body size and weight (none) body length   [cm]  body_length   56702 inbred w/CC8 7 both 17-18wks N=13
    GMC18 body size and weight (none) body size (1=small, 2=normal, 3=big)   [designation]  body_size   56711 inbred w/CC8 8 both 17-18wks N=12
    GMC18 colony observation (none) body type (1=emaciated, 2=slender, 3=normal, 4=pudgy/thick, 5=obese)   [designation]  body_type   56712 inbred w/CC8 8 both 17-18wks N=12
    GMC18 DXA (none) fat tissue mass, without head   [g]  FATmass_Xhead   56721 inbred w/CC8 7 both 17-18wks N=12
    GMC18 DXA (none) lean tissue mass, without head   [g]  LEANmass_Xhead   56722 inbred w/CC8 7 both 17-18wks N=13
    GMC18 DXA (none) total soft tissue mass, without head   [g]  SOFTmass_Xhead   56723 inbred w/CC8 7 both 17-18wks N=13
    GMC18 DXA (none) bone mineral density (BMD), without head   [g/cm2]  BMD_Xhead   56724 inbred w/CC8 7 both 17-18wks N=13
    GMC18 DXA (none) bone area, without head   [cm2]  bone_area_Xhead   56725 inbred w/CC8 7 both 17-18wks N=13
    GMC18 DXA (none) bone mass, without head   [g]  bone_mass_Xhead   56726 inbred w/CC8 7 both 17-18wks N=13
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