MPD: Data set: GMC18

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14. PubMed 32060626 FullText

GMC18 downloads
• Download GMC18 project data set animal data, as uploaded
• Download GMC18 animal data matrix with factor-related expansion applied as necessary
• Download GMC18 strain means, SD, N, etc. one row per strain/sex/measure
• GMC18 supplementary data

Ontology terms mapped to GMC18 measures:

MA:0000009 adipose tissue
MA:0000312 lumbar vertebra
MA:0001459 bone
MP:0001256 abnormal body length
MP:0001259 abnormal body weight
MP:0003795 abnormal bone structure
MP:0003956 abnormal body size
MP:0003959 abnormal lean body mass
MP:0004643 abnormal vertebrae number
MP:0005451 abnormal body composition
MP:0005452 abnormal adipose tissue amount
MP:0010122 abnormal bone mineral content
VT:0001256 body length
VT:0001259 body mass
VT:0005007 bone mineral mass
VT:0005452 adipose amount
VT:0010003 bone morphology trait
VT:0010482 body fat mass
VT:0010483 body lean mass
VT:0100005 body size trait
VT:1000111 bone mass
VT:1000121 lumbar vertebra quantity

Institutional authorship	German Mouse Clinic and Department of Infection Genetics, HZI Lab web site
Investigators	GMC Management Team German Mouse Clinic, Neuherberg GERMANY
Participants	Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Mayer-Kuckuk P, Hans W, Lengger C, Kollmus H, Schughart K
Contact	GMC Management Team coregmc@helmholtz-muenchen.de Lab web site
Affiliated Center	German Mouse Clinic (GMC)
Acknowledgements	Funding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type	Phenotype strain survey data set
MPD identifiers	GMC18 MPD:567
Data changelog	No updates/corrections. Initial release date: 02/2020.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Experimental groups in this study:
• None • None • None • None • None

Procedures conducted:

• body size and weight		Body weight and length.
• DXA		Body mass, fat mass, lean mass, bone mineral density and content, bone area.
• X-ray		Lumbar vertebrae count.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
GMC18:1	GMC18	body size and weight	(none)	body weight [g] bw 56701	inbred w/CC8	8	both	17-18wks	N=12

GMC18:2	GMC18	body size and weight	(none)	body length [cm] body_length 56702	inbred w/CC8	7	both	17-18wks	N=13

GMC18:11	GMC18	body size and weight	(none)	body size (1=small, 2=normal, 3=big) [designation] body_size 56711	inbred w/CC8	8	both	17-18wks	N=12

GMC18:12	GMC18	colony observation	(none)	body type (1=emaciated, 2=slender, 3=normal, 4=pudgy/thick, 5=obese) [designation] body_type 56712	inbred w/CC8	8	both	17-18wks	N=12

GMC18:21	GMC18	DXA	(none)	fat tissue mass, without head [g] FATmass_Xhead 56721	inbred w/CC8	7	both	17-18wks	N=12

GMC18:22	GMC18	DXA	(none)	lean tissue mass, without head [g] LEANmass_Xhead 56722	inbred w/CC8	7	both	17-18wks	N=13

GMC18:23	GMC18	DXA	(none)	total soft tissue mass, without head [g] SOFTmass_Xhead 56723	inbred w/CC8	7	both	17-18wks	N=13

GMC18:24	GMC18	DXA	(none)	bone mineral density (BMD), without head [g/cm²] BMD_Xhead 56724	inbred w/CC8	7	both	17-18wks	N=13

GMC18:25	GMC18	DXA	(none)	bone area, without head [cm²] bone_area_Xhead 56725	inbred w/CC8	7	both	17-18wks	N=13

GMC18:26	GMC18	DXA	(none)	bone mass, without head [g] bone_mass_Xhead 56726	inbred w/CC8	7	both	17-18wks	N=13

GMC18:31	GMC18	DXA	(none)	bone mineral density (BMD), whole body including head [g/cm²] BMD_wholebody 56731	inbred w/CC8	7	both	17-18wks	N=13

GMC18:32	GMC18	DXA	(none)	fat tissue mass, whole body including head [g] FATmass_wholebody 56732	inbred w/CC8	7	both	17-18wks	N=12

GMC18:33	GMC18	DXA	(none)	lean tissue mass, whole body including head [g] LEANmass_wholebody 56733	inbred w/CC8	7	both	17-18wks	N=13

GMC18:34	GMC18	DXA	(none)	total soft tissue mass, whole body including head [g] SOFTmass_wholebody 56734	inbred w/CC8	7	both	17-18wks	N=13

GMC18:35	GMC18	DXA	(none)	bone area, whole body including head [cm²] bone_area_wholebody 56735	inbred w/CC8	7	both	17-18wks	N=13

GMC18:36	GMC18	DXA	(none)	bone mass, whole body including head [g] bone_mass_wholebody 56736	inbred w/CC8	7	both	17-18wks	N=13

GMC18:41	GMC18	X-ray	(none)	number of lumbar vertebrae [n] lumbar_num 56741	inbred w/CC8	8	both	17-18wks	N=12

GMC18: Bone mineral density, body composition, and X-ray analysis of 8 inbred founder strains of the Collaborative Cross (2020)