MPD: Data set: Tarantino3

Tarantino3: Identification of genetic loci that influence locomotor response to cocaine in F2 progeny from CC041/TauUncJ and C57BL/6NJ intercrosses (2025)

Schoenrock SA, Gaines CH, Kumar P, Khan S, Farrington J, Ferris MT, de Villena FP, Valdar W, Bubier JA, Tarantino LM. Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine. Psychopharmacology (Berl). doi: 10.1007/s00213-025-06901-z. PubMed 41143948

Two Collaborative Cross (CC) strains, CC004/TauUncJ (CC004) and CC041/TauUncJ (CC041), were previously shown to differ significantly for locomotor response and self-administration of cocaine. CC041 is a low responding strain while CC004 is a high responding strain. In this study, mapping crosses were generated separately from both strains and C57BL/6NJ to identify genetic loci that are associated with behavioral responses to cocaine. Data for the F2 intercross involving CC041 can be found in this study, and data for the F2 intercross involving CC004 can be found in Tarantino4.

Note on studied population: C57BL/6NJ x CC041/TauUncJ intercrosses

Procedures conducted:

• open field test

Open field test. Distance traveled.

Tarantino3 downloads
• Download Tarantino3 supplementary file, CC041_pheno-1.csv
• Download Tarantino3 supplementary file, CC041_geno-1.csv

Ontology terms mapped to Tarantino3 measures:

Investigators	Lisa M Tarantino University of North Carolina, Chapel Hill, NC Jason A Bubier The Jackson Laboratory, Bar Harbor, ME
Participants	Schoenrock SA, Gaines CH, Kumar P, Khan S, Farrington J, Ferris MT, Pardo-Manuel de Villena F, Valdar W
Contact	Lisa M Tarantino lisat@med.unc.edu
Affiliated Center	Center for Systems Neurogenetics of Addiction (CSNA)
Funding Provided By	NIH DA039841
Project type	QTL Archive data set
MPD identifiers	Tarantino3 MPD:1232
Data changelog	No updates/corrections. Initial release date: 11/2025.

QTL data set parameters:

Progenitor strains	C57BL/6NJ CC041/TauUncJ
Cross direction notation	(CC041xB6N)F1 X (CC041 x B6N)F1; (CC041xB6N)F1 X (B6N x CC041)F1; (B6N x CC041)F1 X (B6N x CC041)F1; (B6N x CC041)F1 X (CC41 x B6N)F1
Cross type	F2 intercross
Population size	220 ♀ 228 ♂
Age	8-10wks

Measured phenotypes: To access these data use the Downloads button near the top of the page

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Tarantino3	open field test	cocaine	distance traveled, 30 min (post-injection) Day 1 (saline), cocaine sensitization [cm] distance_traveled_saline_day_1 142388	QTL population	both	8-10wks	N=448

Tarantino3	open field test	cocaine	distance traveled, 30 min (post-injection) Day 2 (saline), cocaine sensitization [cm] distance_traveled_saline_day_2 142389	QTL population	both	8-10wks	N=448

Tarantino3	open field test	cocaine	distance traveled, 30 min (post-injection) Day 3 (cocaine), cocaine sensitization [cm] distance_traveled_cocaine_day_3 142390	QTL population	both	8-10wks	N=448

Tarantino3	open field test	cocaine	distance traveled, 30 min (post-injection) Day 3 (cocaine) minus Day 2 (saline), cocaine sensitization [cm] distance_traveled_cocaine_day_3_minus_2 142391	QTL population	both	8-10wks	N=448

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Cocia20 Cocia21