Bolivar3: Intra-strain social interactions in 7 inbred strains of mice (2007)

Bolivar VJ, Walters SR, Phoenix JL. Assessing autism-like behavior in mice: variations in social interactions among inbred strains. Behav Brain Res. 2007 Jan 10;176(1):21-6. Epub 2006 Nov 9.   PubMed 17097158     FullText

Bolivar3 downloads
• Download Bolivar3 project data set     one row per animal, one column per trait
• Download Bolivar3 strain means, SD, N, etc.     one row per strain/sex/measure
Ontology terms mapped to Bolivar3 measures:
    MP:0001360   abnormal social investigation
    VT:0001360   social investigation trait
Participants Valerie J Bolivar       Wadsworth Center,  Albany, NY
With: Walters SR, Phoenix JL
ContactValerie J Bolivar     Lab web site
AcknowledgementsFunding provided by NIH MH067850 and MH068013
Project type Phenotype strain survey data set
MPD identifiersBolivar3     MPD:642
Data changelog No updates/corrections.       Initial release date: 03/2019.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
There are two studies in this project on different cohorts of mice. Study 1 was designed to elicit all types of social interactions where one male mouse of a pair was placed in a cage and allowed to explore freely for 15 min. A second male mouse of the same strain was added to the cage. Behavior of the pair was video recorded and later scored by a naive observer. Strain differences were not observed for allogrooming, barbering, or huddling (no cases observed for these activities), and butt sniffing and face sniffing (all mice were observed doing these activities). Strain differences were observed for mounting, wrestling, and following. Study 2 was designed to reduce the number of aggressive behaviors and allow more positive social interactions by adding males of the same strain to the cage simultaneously. Behavior of the pair was video recorded and later scored by a naive observer. In this study, strain differences were not observed for mounting (except one mouse). Strain differences were observed for sniffing, negative social interactions, and positive social interactions. All data for Study 1 and 2 are in the download file for individual animals.

Summary of procedures that were conducted
• monitoring system Social interaction (study 1 and study 2).
Mice: inbred   7 strains   ♂   age 8-12wks   2 cohorts