Tarantino4: Identification of a genetic locus that influences locomotor response to cocaine in F2 progeny from CC004/TauUncJ and C57BL/6NJ intercrosses (2025)

Schoenrock SA, Gaines CH, Kumar P, Khan S, Farrington J, Ferris MT, de Villena FP, Valdar W, Bubier JA, Tarantino LM. Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine. Psychopharmacology (Berl). doi: 10.1007/s00213-025-06901-z.   PubMed 41143948  


       
Two Collaborative Cross (CC) strains, CC004/TauUncJ (CC004) and CC041/TauUncJ (CC041), were previously shown to differ significantly for locomotor response and self-administration of cocaine. CC041 is a low responding strain while CC004 is a high responding strain. In this study, mapping crosses were generated separately from both strains and C57BL/6NJ to identify genetic loci that are associated with behavioral responses to cocaine. Data for the F2 intercross involving CC041 can be found in Tarantino3, and data for the F2 intercross involving CC004 can be found in this study.

Note on studied population: C57BL/6NJ x CC004/TauUncJ intercrosses

Procedures conducted:
• open field test  Open field test. Distance traveled.

No ontology terms have been mapped to Tarantino4 measures.
Investigators Lisa M Tarantino       University of North Carolina,  Chapel Hill, NC
Jason A Bubier       The Jackson Laboratory,  Bar Harbor, ME
Participants Schoenrock SA, Gaines CH, Kumar P, Khan S, Farrington J, Ferris MT, Pardo-Manuel de Villena F, Valdar W
ContactLisa M Tarantino     lisat@med.unc.edu
Affiliated CenterCenter for Systems Neurogenetics of Addiction (CSNA)
Funding Provided ByNIH DA039841
Project type QTL Archive data set
MPD identifiersTarantino4     MPD:1233
Data changelog No updates/corrections.       Initial release date: 11/2025.
QTL data set parameters:
Progenitor strains C57BL/6NJ     CC004/TauUncJ    
Cross direction notation(CC004xB6N)F1 X (CC004 x B6N)F1; (CC004xB6N)F1 X (B6N x CC004)F1; (B6N x CC004)F1 X (B6N x CC004)F1; (B6N x CC004)F1 X (CC004 x B6N)F1
Cross typeF2 intercross
Population size 153 ♀     156 ♂
Age8-10wks


Measured phenotypes:       To access these data use the Downloads button near the top of the page