Bennett4: Diet effects on body composition, plasma chemistry, lipid profile, metabolism, activity, and food intake in females of 22 Collaborative Cross strains of mice (2021)

Yam P, Albright J, VerHague M, Gertz ER, Pardo-Manuel de Villena F, Bennett BJ. Genetic Background Shapes Phenotypic Response to Diet for Adiposity in the Collaborative Cross. Front Genet. 2020;11:615012. doi: 10.3389/fgene.2020.615012. Epub 2021 Feb 11.   PubMed 33643372     FullText

Bennett4 downloads
• Download Bennett4 project data set     animal data, as uploaded
• Download Bennett4 animal data matrix     with factor-related expansion applied as necessary
• Download Bennett4 strain means, SD, N, etc.     one row per strain/sex/measure
Ontology terms mapped to Bennett4 measures:
  MA:0000009   adipose tissue
  MA:0000327   respiratory system
  MA:0002501   plasma
  MP:0000188   abnormal circulating glucose level
  MP:0000199   abnormal circulating serum albumin level
  MP:0000203   abnormal circulating aspartate transaminase level
  MP:0000676   abnormal body water content
  MP:0001259   abnormal body weight
  MP:0001392   abnormal locomotor behavior
  MP:0001553   abnormal circulating free fatty acids level
  MP:0001560   abnormal circulating insulin level
  MP:0001573   abnormal circulating alanine transaminase level
  MP:0002336   abnormal pulmonary gas exchange
  MP:0003947   abnormal cholesterol level
  MP:0003959   abnormal lean body mass
  MP:0003977   abnormal circulating carnitine level
  MP:0005265   abnormal blood urea nitrogen level
  MP:0005288   abnormal oxygen consumption
  MP:0005328   abnormal circulating creatinine level
  MP:0005376   homeostasis/metabolism phenotype
  MP:0005448   abnormal energy homeostasis
  MP:0005449   abnormal food intake
  MP:0005450   abnormal energy expenditure
  MP:0005452   abnormal adipose tissue amount
  MP:0005457   abnormal percent body fat/body weight
  MP:0008962   abnormal carbon dioxide production
  MP:0011969   abnormal circulating triglyceride level
  MP:0021122   abnormal trimethylamine N-oxide level
  MP:0021125   abnormal phosphocholine level
  MP:0021129   abnormal glycerophosphocholine level
  MP:0021132   abnormal amino acid betaine level
  MP:0030752   abnormal choline level
  VT:0000188   blood glucose amount
  VT:0000199   blood albumin amount
  VT:0000203   blood aspartate transaminase amount
  VT:0001259   body mass
  VT:0001392   locomotor behavior trait
  VT:0001431   eating behavior trait
  VT:0001553   blood free fatty acid amount
  VT:0001560   blood insulin amount
  VT:0001573   blood alanine transaminase amount
  VT:0001764   homeostasis trait
  VT:0002121   metabolism trait
  VT:0002336   pulmonary gas exchange trait
  VT:0002338   pulmonary ventilation trait
  VT:0002644   blood triglyceride amount
  VT:0003947   cholesterol amount
  VT:0003977   blood carnitine amount
  VT:0005265   blood urea nitrogen amount
  VT:0005328   blood creatinine amount
  VT:0005448   energy balance trait
  VT:0005450   energy expenditure trait
  VT:0010482   body fat mass
  VT:0010483   body lean mass
  VT:0010748   stereotypic behavior trait
  VT:0010999   body water amount
  VT:0011000   choline amount
  VT:0011001   trimethylamine N-oxide amount
  VT:0011002   betaine amount
  VT:0011003   phosphocholine amount
  VT:0011004   glycerophosphocholine amount
  VT:1000152   wellness/fitness trait

Investigators Phoebe Yam       University of California, Davis,  Davis, CA
Brian J Bennett       University of California, Davis,  Davis, CA
Participants Albright J, VerHague M, Gertz ER, Pardo-Manuel de Villena F.
ContactBrian J Bennett     Lab web site
Funding Provided ByNIH HL128572, DK056350; Nutrition Research Institute; United States Department of Agriculture /Agricultural Research Service (ARS)/Western Human Nutrition Research Center project funds (2032-51000-022-00D)
Project type Phenotype strain survey data set
MPD identifiersBennett4     MPD:1119
Data changelog No updates/corrections.       Initial release date: 04/2022.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Experimental groups in this study:
• High protein (HP) diet     • High-fat high-sucrose (HFHS) diet    

Procedures conducted:
• body weight 
• MRI  Body composition (lean, fat, water).
• metabolic panel  Plasma enzymes, creatinine, glucose, urea, metabolic health score.
• lipid profile  Cholesterol, non-esterified fatty acids, triglyceride.
• biomarker quantification  TMAO, choline, phosphocholine, glycerophosphocholine, betaine, carnitine.
• hormone quantification  Insulin, glucose:insulin ratio.
• monitoring system  O2 consumption, CO2 production, RER, heat expenditure, activity.
• intake monitoring  Food intake; energy intake; protein, carbohydrate, fat intake.

Mice: None   22 strains   ♀♂   age 8-20wks   2 experimental groups