MPD: Data set: Bennett4

Bennett4: Diet effects on body composition, plasma chemistry, lipid profile, metabolism, activity, and food intake in females of 22 Collaborative Cross strains of mice (2021)

Yam P, Albright J, VerHague M, Gertz ER, Pardo-Manuel de Villena F, Bennett BJ. Genetic Background Shapes Phenotypic Response to Diet for Adiposity in the Collaborative Cross. Front Genet. 2020;11:615012. doi: 10.3389/fgene.2020.615012. Epub 2021 Feb 11. PubMed 33643372 FullText

Experimental groups in this study:
• High protein (HP) diet • High-fat high-sucrose (HFHS) diet

Procedures conducted:

• body weight
• MRI		Body composition (lean, fat, water).
• metabolic panel		Plasma enzymes, creatinine, glucose, urea, metabolic health score.
• lipid profile		Cholesterol, non-esterified fatty acids, triglyceride.
• biomarker quantification		TMAO, choline, phosphocholine, glycerophosphocholine, betaine, carnitine.
• hormone quantification		Insulin, glucose:insulin ratio.
• monitoring system		O₂ consumption, CO₂ production, RER, heat expenditure, activity.
• intake monitoring		Food intake; energy intake; protein, carbohydrate, fat intake.

Bennett4 downloads
• Download Bennett4 project data set animal data, as uploaded
• Download Bennett4 animal data matrix with factor-related expansion applied as necessary
• Download Bennett4 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Bennett4 measures:

Investigators	Phoebe Yam University of California, Davis, Davis, CA Brian J Bennett University of California, Davis, Davis, CA
Participants	Albright J, VerHague M, Gertz ER, Pardo-Manuel de Villena F.
Contact	Brian J Bennett brian.bennett@usda.gov Lab web site
Funding Provided By	NIH HL128572, DK056350; Nutrition Research Institute; United States Department of Agriculture /Agricultural Research Service (ARS)/Western Human Nutrition Research Center project funds (2032-51000-022-00D)
Project type	Phenotype strain survey data set
MPD identifiers	Bennett4 MPD:1119
Data changelog	No updates/corrections. Initial release date: 04/2022.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Mice: None 22 strains ♀♂ age 8-20wks 2 experimental groups

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Bennett4:7	Bennett4	body weight	various diets 2	body weight, baseline [g] bw_base 114701 diet: HP group HFHS group	CC	22	f	8-11wks	N=5

Bennett4:9	Bennett4	body weight	various diets 2	body weight, post-diet [g] bw_post 114703 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4:11	Bennett4	MRI	various diets 2	fat mass, baseline [g] fat_base 114705 diet: HP group HFHS group	CC	22	f	8-10wks	N=5

Bennett4:13	Bennett4	MRI	various diets 2	fat mass, post-diet [g] fat_post 114707 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4:15	Bennett4	MRI	various diets 2	percentage of body weight that is fat, baseline [%] fat_pct_base 114709 diet: HP group HFHS group	CC	22	f	8-11wks	N=5

Bennett4:17	Bennett4	MRI	various diets 2	percentage of body weight that is fat, post-diet [%] fat_pct_post 114711 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4:19	Bennett4	MRI	various diets 2	lean mass, baseline [g] lean_base 114713 diet: HP group HFHS group	CC	22	f	8-11wks	N=5

Bennett4:21	Bennett4	MRI	various diets 2	lean mass, post-diet [g] lean_post 114715 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4:23	Bennett4	MRI	various diets 2	percentage of body weight that is lean, baseline [%] lean_pct_base 114717 diet: HP group HFHS group	CC	22	f	8-11wks	N=5

Bennett4:25	Bennett4	MRI	various diets 2	percentage of body weight that is lean, post-diet [%] lean_pct_post 114719 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4:27	Bennett4	MRI	various diets 2	free water mass, baseline [g] water_free_base 114721 diet: HP group HFHS group	CC	22	f	8-11wks	N=5

Bennett4:29	Bennett4	MRI	various diets 2	free water mass, post-diet [g] water_free_post 114723 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4:31	Bennett4	MRI	various diets 2	total water mass, baseline [g] water_tot_base 114725 diet: HP group HFHS group	CC	22	f	8-11wks	N=5

Bennett4:33	Bennett4	MRI	various diets 2	total water mass, post-diet [g] water_tot_post 114727 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4:35	Bennett4	metabolic panel	various diets 2	plasma albumin amount, baseline [g/L] ALB_base 114729 diet: HP group HFHS group	CC	22	f	8-11wks	N=5

Bennett4:37	Bennett4	metabolic panel	various diets 2	plasma albumin amount, post-diet [g/L] ALB_post 114731 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4:39	Bennett4	metabolic panel	various diets 2	plasma alanine aminotransferase (ALT) amount, baseline [U/L] ALT_base 114733 diet: HP group HFHS group	CC	22	f	8-11wks	N=5

Bennett4:41	Bennett4	metabolic panel	various diets 2	plasma alanine aminotransferase (ALT) amount, post-diet [U/L] ALT_post 114735 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4:43	Bennett4	metabolic panel	various diets 2	plasma aspartate aminotransferase (AST) amount, baseline [U/L] AST_base 114737 diet: HP group HFHS group	CC	22	f	8-11wks	N=5

Bennett4:45	Bennett4	metabolic panel	various diets 2	plasma aspartate aminotransferase (AST) amount, post-diet [U/L] AST_post 114739 diet: HP group HFHS group	CC	22	f	17-20wks	N=4

Bennett4: Diet effects on body composition, plasma chemistry, lipid profile, metabolism, activity, and food intake in females of 22 Collaborative Cross strains of mice (2021)

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