GMC03: Dysmorphology and SHIRPA behavioral and neuromuscular assessment in 8 inbred founder strains of the Collaborative Cross (2020)

Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A, Mouse Phenome Database Team., Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M. A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb;31(1-2):30-48. doi: 10.1007/s00335-020-09827-3. Epub 2020 Feb 14.   PubMed 32060626     FullText

          List all GMC measures
GMC03 downloads
• Download GMC03 project data set     animal data, as uploaded
• Download GMC03 animal data matrix     with factor-related expansion applied as necessary
• Download GMC03 strain means, SD, N, etc.     one row per strain/sex/measure
• GMC03 supplementary data
Ontology terms mapped to GMC03 measures:
  MA:0000007   limb
  MA:0000008   tail
  MA:0000020   back of trunk
  MA:0000155   coat hair
  MA:0000163   vibrissa
  MA:0000259   auricle
  MA:0000261   eye
  MA:0000520   abdomen muscle
  MP:0001259   abnormal body weight
  MP:0001348   abnormal lacrimal gland physiology
  MP:0001362   abnormal anxiety-related response
  MP:0001392   abnormal locomotor behavior
  MP:0001406   abnormal gait
  MP:0001504   abnormal posture
  MP:0001510   abnormal coat appearance
  MP:0001513   limb grasping
  MP:0001529   abnormal vocalization
  MP:0001761   abnormal urination pattern
  MP:0002061   abnormal aggression-related behavior
  MP:0002066   abnormal motor capabilities/coordination/movement
  MP:0002098   abnormal vibrissa morphology
  MP:0003492   abnormal involuntary movement
  MP:0003671   abnormal eyelid aperture
  MP:0005316   abnormal response to tactile stimuli
  MP:0013189   abnormal exploration in a new environment
  MP:0020147   abnormal defecation amount
  VT:0000367   coat/hair morphology trait
  VT:0001259   body mass
  VT:0001280   vibrissa retention trait
  VT:0001392   locomotor behavior trait
  VT:0001529   vocalization trait
  VT:0003492   involuntary movement trait
  VT:0003620   urine output
  VT:0005316   tactition trait
  VT:0006276   autonomic nervous system physiology trait
  VT:0010080   skeletal muscle physiology trait
  VT:0010461   excretion behavior trait
  VT:0010462   defecation behavior trait
  VT:0010471   exploratory behavior trait
  VT:0010716   anxiety-related behavior trait
  VT:0010726   wildness behavior trait
  VT:0015014   aggression-related behavior trait
  VT:0015094   equilibrioception system trait
  VT:1000000   body conformation trait

Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Becker L, Klopstock T, Hans W, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC03     MPD:552
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
SHIRPA is a standardized set of procedures used to characterize the phenotype of laboratory mice. The procedures are designed as a first-pass phenotyping screen to test muscle function, cerebellar function, sensory function and neuropsychiatric function. The modified SHIRPA includes observations on morphology and dysmorphology. Dysmorphology assessments at 12 wks of age are available in a supplemental data file (see Downloads).

Experimental groups in this study:
• None     • None     • None     • None     • None    

Procedures conducted:
• observation (SHIRPA)  Behavior, and neurosensory responses (SHIRPA protocol).

Mice: inbred w/CC8   8 strains   ♀♂   age 8-10wks   5 experimental groups