GMC03: Dysmorphology and SHIRPA behavioral and neuromuscular assessment in 8 inbred founder strains of the Collaborative Cross (2020)

German Mouse Clinic and Department of Infection Genetics, HZI   GMC Management Team   With: Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Becker L, Klopstock T, Hans W, Lengger C, Kollmus H, Schughart K

          List all GMC measures
GMC03 downloads
• Download GMC03 project data set     one row per animal, one column per trait (uploaded by Curator)
• Download GMC03 individual animal data     one row per animal, one column per trait (generated from uploaded data)
• Download GMC03 strain means, SD, N, etc.     one row per strain/sex/measure (generated from uploaded data)
• GMC03 supplementary data
Ontology terms mapped to GMC03 measures:
    MA:0000007   limb
    MA:0000008   tail
    MA:0000020   back of trunk
    MA:0000155   coat hair
    MA:0000163   vibrissa
    MA:0000259   auricle
    MA:0000261   eye
    MA:0000520   abdomen muscle
    MP:0001259   abnormal body weight
    MP:0001348   abnormal lacrimal gland physiology
    MP:0001362   abnormal anxiety-related response
    MP:0001392   abnormal locomotor behavior
    MP:0001406   abnormal gait
    MP:0001504   abnormal posture
    MP:0001510   abnormal coat appearance
    MP:0001513   limb grasping
    MP:0001529   abnormal vocalization
    MP:0001761   abnormal urination pattern
    MP:0002061   abnormal aggression-related behavior
    MP:0002066   abnormal motor capabilities/coordination/movement
    MP:0002098   abnormal vibrissa morphology
    MP:0003492   abnormal involuntary movement
    MP:0003671   abnormal eyelid aperture
    MP:0005316   abnormal response to tactile stimuli
    MP:0013189   abnormal exploration in a new environment
    MP:0020147   abnormal defecation amount
    VT:0000367   coat/hair morphology trait
    VT:0001259   body mass
    VT:0001280   vibrissa retention trait
    VT:0001392   locomotor behavior trait
    VT:0001529   vocalization trait
    VT:0003492   involuntary movement trait
    VT:0003620   urine output
    VT:0005316   tactition trait
    VT:0006276   autonomic nervous system physiology trait
    VT:0010080   skeletal muscle physiology trait
    VT:0010461   excretion behavior trait
    VT:0010462   defecation behavior trait
    VT:0010471   exploratory behavior trait
    VT:0010716   anxiety-related behavior trait
    VT:0010726   wildness behavior trait
    VT:0015014   aggression-related behavior trait
    VT:0015094   equilibrioception system trait
    VT:1000000   body conformation trait
Institutional authorship German Mouse Clinic and Department of Infection Genetics, HZI     Lab web site
Investigators GMC Management Team       German Mouse Clinic,  Neuherberg GERMANY
Participants Hrabě de Angelis M, Fuchs H, Gailus-Durner V, Becker L, Klopstock T, Hans W, Lengger C, Kollmus H, Schughart K
ContactGMC Management Team     coregmc@helmholtz-muenchen.de     Lab web site
Affiliated CenterGerman Mouse Clinic (GMC)
AcknowledgementsFunding provided by German Ministry of Education and Research (Infrafrontier Grant 01KX1012) to GMC and by intramural grants from the Helmholtz Association (Program Infection and Immunity) to KS
Project type Phenotype strain survey data set
MPD identifiersGMC03     MPD:552
Data changelog No updates/corrections.       Initial release date: 02/2020.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
SHIRPA is a standardized set of procedures used to characterize the phenotype of laboratory mice. The procedures are designed as a first-pass phenotyping screen to test muscle function, cerebellar function, sensory function and neuropsychiatric function. The modified SHIRPA includes observations on morphology and dysmorphology. Dysmorphology assessments at 12 wks of age are available in a supplemental data file (see Downloads).

Summary of procedures that were conducted
• observation (SHIRPA) Behavior, and neurosensory responses (SHIRPA protocol).
Mice: inbred w/CC8   8 strains   ♀♂   age 8-10wks   5 experimental groups