Glass1: Swallow function in the adult Ts65Dn mouse model of Down Syndrome (2025)

Glass TJ, Russell JA, Fisher EH, Ostadi M, Aori N, Yu YE, Connor NP. Altered tongue muscle contractile properties coincide with altered swallow function in the adult Ts65Dn mouse model of down syndrome. Front Neurol. 2024;15:1384572. doi: 10.3389/fneur.2024.1384572. Epub 2024 Mar 22.   PubMed 38585362     FullText


         
The Ts65Dn mouse model of Down Syndrome and wild type sibling controls were evaluated by videofluoroscopic swallow studies (VFSS) to quantify measures of swallow function. Separate cohorts of mice were evaluated at 5 months of age and 20 months of age. Mice were imaged while consuming a puree of cheese dip mixed with barium contrast agent.

Experimental groups in this study:
• Baseline for 5 mo and 20 mo old mice    

No ontology terms have been mapped to Glass1 measures.
Investigators Tiffany J Glass       University of Wisconsin,  Madison, WI
Nadine P Connor       University of Wisconsin,  Madison, WI
Erin H Fisher       University of Wisconsin,  Madison, WI
Ostadi Marziyeh       University of Wisconsin,  Madison, WI
ContactTiffany J Glass     tjglass@wisc.edu     Lab web site
Funding Provided ByNIH DC019735
Project type Phenotype strain survey data set
MPD identifiersGlass1     MPD:1240
Data changelog No updates/corrections.       Initial release date: 12/2025.
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[No procedure abstracts have been defined yet]
Mice: other   ♀♂   age 5 and 20 mo   1 experimental group


No phenotype measures have been accessioned yet.