HMDPpheno7: Liver metabolite levels: Carbohydrates, cofactors and vitamins, energy, and xenobiotics in males of 104 strains of the Hybrid Mouse Diversity Panel (HMDP) (2014)

Ghazalpour A, Bennett BJ, Shih D, Che N, Orozco L, Pan C, Hagopian R, He A, Kayne P, Yang WP, Kirchgessner T, Lusis AJ. Genetic regulation of mouse liver metabolite levels. Mol Syst Biol. 2014 May 23;10(5):730. doi: 10.15252/msb.20135004.   PubMed 24860088  


       
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Participants Anatole Ghazalpour       University of California, Los Angeles Los Angeles, CA
Brian J Bennett       University of North Carolina Chapel Hill, NC
Luz Orozco       University of California, Los Angeles Los Angeles, CA
Aldons J Lusis       University of California, Los Angeles Los Angeles, CA
With: Shih D, Che N, Pan C, Hagopian R, He A, Kayne P, Yang W-P
ContactAnatole Ghazalpour     aghazalp@ucla.edu     Lab web site
AffiliationHybrid Mouse Diversity Panel Group (HMDP)
Part of a series: • Metabolite survey: Amino acids   see HMDPpheno6
• Metabolite survey: Carbs, cofactors, vitamins, energy, xenobiotics   (this project) HMDPpheno7
• Metabolite survey: Lipids (non-lysolipids)   see HMDPpheno8
• Metabolite survey: Lipids (lysolipids)   see HMDPpheno9
• Metabolite survey: Nucleotides, peptides   see HMDPpheno10
Project type Phenotype strain survey data set
MPD identifiersHMDPpheno7     MPD:502
Data changelog No updates/corrections.       Initial release date: 06/2014.
Formatted citation
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Summary of procedures that were conducted
• metabolite quantification Liver metabolic profiling. Molecular measures of carbs, cofactors, vitamins, energy, xenobiotics. 16h fast.
Mice: HMDP w/par   106 strains   ♂   age 16wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    HMDPpheno7 50201 metabolite quantification (none) erythronate (16h fast), relative abundance  erythronate HMDP 102 m 16wks N=1
    HMDPpheno7 50202 metabolite quantification (none) glucosamine (16h fast), relative abundance  glucosamine HMDP 93 m 16wks N=1
    HMDPpheno7 50203 metabolite quantification (none) erythrose (16h fast), relative abundance  erythrose HMDP 106 m 16wks N=1
    HMDPpheno7 50204 metabolite quantification (none) fructose (16h fast), relative abundance  fructose HMDP 106 m 16wks N=1
    HMDPpheno7 50205 metabolite quantification (none) maltose (16h fast), relative abundance  maltose HMDP 94 m 16wks N=1
    HMDPpheno7 50206 metabolite quantification (none) mannose (16h fast), relative abundance  mannose HMDP 106 m 16wks N=1
    HMDPpheno7 50207 metabolite quantification (none) sorbitol (16h fast), relative abundance  sorbitol HMDP 106 m 16wks N=1
    HMDPpheno7 50208 metabolite quantification (none) maltotetraose (16h fast), relative abundance  maltotetraose HMDP 100 m 16wks N=1
    HMDPpheno7 50209 metabolite quantification (none) 1,5-anhydroglucitol (1,5-AG) (16h fast), relative abundance  anhydroglucitol HMDP 105 m 16wks N=1
    HMDPpheno7 50210 metabolite quantification (none) glucose (16h fast), relative abundance  glucose HMDP 106 m 16wks N=1
    HMDPpheno7 50211 metabolite quantification (none) glucuronate (16h fast), relative abundance  glucuronate HMDP 104 m 16wks N=1
    HMDPpheno7 50212 metabolite quantification (none) glycerate (16h fast), relative abundance  glycerate HMDP 106 m 16wks N=1
    HMDPpheno7 50213 metabolite quantification (none) lactate (16h fast), relative abundance  lactate HMDP 106 m 16wks N=1
    HMDPpheno7 50214 metabolite quantification (none) 3-phosphoglycerate (16h fast), relative abundance  phosphoglycerate HMDP 105 m 16wks N=1
    HMDPpheno7 50215 metabolite quantification (none) gluconate (16h fast), relative abundance  gluconate HMDP 106 m 16wks N=1
    HMDPpheno7 50216 metabolite quantification (none) 2-ketogulonate (16h fast), relative abundance  ketogulonate HMDP 97 m 16wks N=1
    HMDPpheno7 50217 metabolite quantification (none) ribitol (16h fast), relative abundance  ribitol HMDP 106 m 16wks N=1
    HMDPpheno7 50218 metabolite quantification (none) ribose (16h fast), relative abundance  ribose HMDP 106 m 16wks N=1
    HMDPpheno7 50219 metabolite quantification (none) ribulose (16h fast), relative abundance  ribulose HMDP 106 m 16wks N=1
    HMDPpheno7 50220 metabolite quantification (none) xylitol (16h fast), relative abundance  xylitol HMDP 106 m 16wks N=1
    HMDPpheno7 50221 metabolite quantification (none) xylonate (16h fast), relative abundance  xylonate HMDP 106 m 16wks N=1
    HMDPpheno7 50222 metabolite quantification (none) 6-phosphogluconate (16h fast), relative abundance  phosphogluconate HMDP 106 m 16wks N=1
    HMDPpheno7 50223 metabolite quantification (none) UDP-glucose (16h fast), relative abundance  UDP_glucose HMDP 105 m 16wks N=1
    HMDPpheno7 50224 metabolite quantification (none) arabonate (16h fast), relative abundance  arabonate HMDP 85 m 16wks N=1
    HMDPpheno7 50225 metabolite quantification (none) ascorbate (Vitamin C) (16h fast), relative abundance  ascorbate HMDP 94 m 16wks N=1
    HMDPpheno7 50226 metabolite quantification (none) glucarate (saccharate) (16h fast), relative abundance  glucarate HMDP 106 m 16wks N=1
    HMDPpheno7 50227 metabolite quantification (none) gulono-1,4-lactone (16h fast), relative abundance  lactone HMDP 106 m 16wks N=1
    HMDPpheno7 50228 metabolite quantification (none) threonate (16h fast), relative abundance  threonate HMDP 106 m 16wks N=1
    HMDPpheno7 50229 metabolite quantification (none) biopterin (16h fast), relative abundance  biopterin HMDP 106 m 16wks N=1
    HMDPpheno7 50230 metabolite quantification (none) 5-methyltetrahydrofolate (5MeTHF) (16h fast), relative abundance  MeTHF HMDP 93 m 16wks N=1
    HMDPpheno7 50231 metabolite quantification (none) nicotinamide adenine dinucleotide (NAD+) (16h fast), relative abundance  NAD HMDP 106 m 16wks N=1
    HMDPpheno7 50232 metabolite quantification (none) nicotinamide (16h fast), relative abundance  nicotinamide HMDP 106 m 16wks N=1
    HMDPpheno7 50233 metabolite quantification (none) trigonelline (N'-methylnicotinate) (16h fast), relative abundance  trigonelline HMDP 106 m 16wks N=1
    HMDPpheno7 50234 metabolite quantification (none) pantothenate (16h fast), relative abundance  pantothenate HMDP 106 m 16wks N=1
    HMDPpheno7 50235 metabolite quantification (none) riboflavin (Vitamin B2) (16h fast), relative abundance  riboflavin HMDP 106 m 16wks N=1
    HMDPpheno7 50236 metabolite quantification (none) flavin adenine dinucleotide (FAD) (16h fast), relative abundance  FAD HMDP 106 m 16wks N=1
    HMDPpheno7 50237 metabolite quantification (none) flavin mononucleotide (FMN) (16h fast), relative abundance  FMN HMDP 105 m 16wks N=1
    HMDPpheno7 50238 metabolite quantification (none) thiamin (Vitamin B1) (16h fast), relative abundance  thiamin HMDP 106 m 16wks N=1
    HMDPpheno7 50239 metabolite quantification (none) pyridoxate (16h fast), relative abundance  pyridoxate HMDP 106 m 16wks N=1
    HMDPpheno7 50240 metabolite quantification (none) citrate (16h fast), relative abundance  citrate HMDP 104 m 16wks N=1
    HMDPpheno7 50241 metabolite quantification (none) fumarate (16h fast), relative abundance  fumarate HMDP 106 m 16wks N=1
    HMDPpheno7 50242 metabolite quantification (none) malate (16h fast), relative abundance  malate HMDP 106 m 16wks N=1
    HMDPpheno7 50243 metabolite quantification (none) succinylcarnitine (16h fast), relative abundance  succinylcarnitine HMDP 93 m 16wks N=1
    HMDPpheno7 50244 metabolite quantification (none) cis-aconitate (16h fast), relative abundance  aconitate HMDP 101 m 16wks N=1
    HMDPpheno7 50245 metabolite quantification (none) acetylphosphate (16h fast), relative abundance  acetylphosphate HMDP 106 m 16wks N=1
    HMDPpheno7 50246 metabolite quantification (none) phosphate (16h fast), relative abundance  phosphate HMDP 106 m 16wks N=1
    HMDPpheno7 50247 metabolite quantification (none) glycerol 2-phosphate (16h fast), relative abundance  glycerol_phosphate HMDP 106 m 16wks N=1
    HMDPpheno7 50248 metabolite quantification (none) methyl-alpha-glucopyranoside (16h fast), relative abundance  glucopyranoside HMDP 105 m 16wks N=1
    HMDPpheno7 50249 metabolite quantification (none) N-glycolylneuraminate (16h fast), relative abundance  glycolylneuraminate HMDP 100 m 16wks N=1
    HMDPpheno7 50250 metabolite quantification (none) ergothioneine (16h fast), relative abundance  ergothioneine HMDP 106 m 16wks N=1
    HMDPpheno7 50251 metabolite quantification (none) erythritol (16h fast), relative abundance  erythritol HMDP 106 m 16wks N=1
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