Phenotype measure:   HMDPpheno7   trigonelline

ID, description, units MPD:50233   trigonelline   liver trigonelline (N'-methylnicotinate) (16h fast), relative abundance  
Data set, strains HMDPpheno7   HMDP   106 strains     sex: m     age: 16wks
Procedure metabolite quantification
Ontology mappings

  STRAIN COMPARISON PLOT
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HMDPpheno7 - liver trigonelline (N'-methylnicotinate) (16h fast), relative abundance



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested106 strains
Mean of the strain means279753   None
Median of the strain means251580   None
SD of the strain means± 170734
Coefficient of variation (CV)0.610
Min–max range of strain means91802   –   1793814   None
Mean sample size per strain1.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 21 341472725386.119 16260605970.7676 2.479 0.009
Residuals 34 223013451186.484 6559219152.5436


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129X1/SvJ m 364953.0 0.0   1   0.0 0.0 364953.0, 364953.0 0.5
A/J m 332559.0 121883.0   2   86185.0 0.367 246374.0, 418743.0 0.31
AKR/J m 291166.0 0.0   1   0.0 0.0 291166.0, 291166.0 0.07
AXB10/PgnJ m 218225.0 0.0   1   0.0 0.0 218225.0, 218225.0 -0.36
AXB12/PgnJ m 240604.0 0.0   1   0.0 0.0 240604.0, 240604.0 -0.23
AXB13/PgnJ m 389388.0 0.0   1   0.0 0.0 389388.0, 389388.0 0.64
AXB15/PgnJ m 181962.0 0.0   1   0.0 0.0 181962.0, 181962.0 -0.57
AXB19a/PgnJ m 212031.0 0.0   1   0.0 0.0 212031.0, 212031.0 -0.4
AXB19b/PgnJ m 246814.0 25584.0   2   18091.0 0.104 228723.0, 264904.0 -0.19
AXB19/PgnJ m 175075.0 0.0   1   0.0 0.0 175075.0, 175075.0 -0.61
AXB1/PgnJ m 164541.0 0.0   1   0.0 0.0 164541.0, 164541.0 -0.67
AXB23/PgnJ m 393759.0 0.0   1   0.0 0.0 393759.0, 393759.0 0.67
AXB24/PgnJ m 216879.0 6660.0   2   4709.0 0.0307 212170.0, 221588.0 -0.37
AXB2/PgnJ m 222114.0 0.0   1   0.0 0.0 222114.0, 222114.0 -0.34
AXB4/PgnJ m 202183.0 0.0   1   0.0 0.0 202183.0, 202183.0 -0.45
AXB5/PgnJ m 268025.0 0.0   1   0.0 0.0 268025.0, 268025.0 -0.07
AXB6/PgnJ m 338508.0 0.0   1   0.0 0.0 338508.0, 338508.0 0.34
AXB8/PgnJ m 250362.0 0.0   1   0.0 0.0 250362.0, 250362.0 -0.17
BALB/cJ m 323682.0 111253.0   3 64232.0 0.344 195263.0, 390805.0 0.26
BTBR T+ Itpr3tf/J m 201100.0 0.0   1   0.0 0.0 201100.0, 201100.0 -0.46
BUB/BnJ m 257115.0 0.0   1   0.0 0.0 257115.0, 257115.0 -0.13
BXA11/PgnJ m 225852.0 0.0   1   0.0 0.0 225852.0, 225852.0 -0.32
BXA12/PgnJ m 231837.0 0.0   1   0.0 0.0 231837.0, 231837.0 -0.28
BXA13/PgnJ m 246046.0 0.0   1   0.0 0.0 246046.0, 246046.0 -0.2
BXA14/PgnJ m 548100.0 0.0   1   0.0 0.0 548100.0, 548100.0 1.57
BXA16/PgnJ m 255005.0 33308.0   2   23552.0 0.131 231453.0, 278558.0 -0.14
BXA1/PgnJ m 199760.0 0.0   1   0.0 0.0 199760.0, 199760.0 -0.47
BXA24/PgnJ m 283749.0 0.0   1   0.0 0.0 283749.0, 283749.0 0.02
BXA25/PgnJ m 238639.0 0.0   1   0.0 0.0 238639.0, 238639.0 -0.24
BXA26/PgnJ m 205478.0 0.0   1   0.0 0.0 205478.0, 205478.0 -0.44
BXA2/PgnJ m 283507.0 0.0   1   0.0 0.0 283507.0, 283507.0 0.02
BXA4/PgnJ m 191773.0 0.0   1   0.0 0.0 191773.0, 191773.0 -0.52
BXA7/PgnJ m 355211.0 0.0   1   0.0 0.0 355211.0, 355211.0 0.44
BXA8/PgnJ m 286774.0 0.0   1   0.0 0.0 286774.0, 286774.0 0.04
BXD11/TyJ m 233749.0 0.0   1   0.0 0.0 233749.0, 233749.0 -0.27
BXD12/TyJ m 340846.0 0.0   1   0.0 0.0 340846.0, 340846.0 0.36
BXD13/TyJ m 256787.0 0.0   1   0.0 0.0 256787.0, 256787.0 -0.13
BXD14/TyJ m 332984.0 0.0   1   0.0 0.0 332984.0, 332984.0 0.31
BXD15/TyJ m 189490.0 0.0   1   0.0 0.0 189490.0, 189490.0 -0.53
BXD18/TyJ m 147051.0 0.0   1   0.0 0.0 147051.0, 147051.0 -0.78
BXD19/TyJ m 192384.0 60640.0   2   42879.0 0.315 149505.0, 235263.0 -0.51
BXD1/TyJ m 242770.0 0.0   1   0.0 0.0 242770.0, 242770.0 -0.22
BXD20/TyJ m 202747.0 0.0   1   0.0 0.0 202747.0, 202747.0 -0.45
BXD21/TyJ m 167709.0 0.0   1   0.0 0.0 167709.0, 167709.0 -0.66
BXD22/TyJ m 161501.0 0.0   1   0.0 0.0 161501.0, 161501.0 -0.69
BXD24/TyJ m 214975.0 0.0   1   0.0 0.0 214975.0, 214975.0 -0.38
BXD24/TyJ-Cep290rd16/J m 204393.0 0.0   1   0.0 0.0 204393.0, 204393.0 -0.44
BXD28/TyJ m 205262.0 8284.0   2   5858.0 0.0404 199405.0, 211120.0 -0.44
BXD29-Tlr4lps-2J/J m 311821.0 0.0   1   0.0 0.0 311821.0, 311821.0 0.19
BXD2/TyJ m 242688.0 0.0   1   0.0 0.0 242688.0, 242688.0 -0.22
BXD32/TyJ m 270436.0 0.0   1   0.0 0.0 270436.0, 270436.0 -0.05
BXD33/TyJ m 189119.0 0.0   1   0.0 0.0 189119.0, 189119.0 -0.53
BXD34/TyJ m 263894.0 0.0   1   0.0 0.0 263894.0, 263894.0 -0.09
BXD36/TyJ m 220834.0 0.0   1   0.0 0.0 220834.0, 220834.0 -0.35
BXD38/TyJ m 304062.0 0.0   1   0.0 0.0 304062.0, 304062.0 0.14
BXD39/TyJ m 446935.0 0.0   1   0.0 0.0 446935.0, 446935.0 0.98
BXD40/TyJ m 312146.0 0.0   1   0.0 0.0 312146.0, 312146.0 0.19
BXD42/TyJ m 263739.0 0.0   1   0.0 0.0 263739.0, 263739.0 -0.09
BXD5/TyJ m 167098.0 0.0   1   0.0 0.0 167098.0, 167098.0 -0.66
BXD6/TyJ m 298079.0 0.0   1   0.0 0.0 298079.0, 298079.0 0.11
BXD8/TyJ m 166897.0 0.0   1   0.0 0.0 166897.0, 166897.0 -0.66
BXD9/TyJ m 207393.0 0.0   1   0.0 0.0 207393.0, 207393.0 -0.42
BXH10/TyJ m 602379.0 0.0   1   0.0 0.0 602379.0, 602379.0 1.89
BXH19/TyJ m 170732.0 0.0   1   0.0 0.0 170732.0, 170732.0 -0.64
BXH20/KccJ m 294986.0 0.0   1   0.0 0.0 294986.0, 294986.0 0.09
BXH22/KccJ m 210875.0 0.0   1   0.0 0.0 210875.0, 210875.0 -0.4
BXH2/TyJ m 244682.0 0.0   1   0.0 0.0 244682.0, 244682.0 -0.21
BXH4/TyJ m 204760.0 19424.0   2   13735.0 0.0949 191025.0, 218495.0 -0.44
BXH6/TyJ m 295679.0 0.0   1   0.0 0.0 295679.0, 295679.0 0.09
BXH7/TyJ m 280870.0 0.0   1   0.0 0.0 280870.0, 280870.0 0.01
BXH8/TyJ m 219712.0 0.0   1   0.0 0.0 219712.0, 219712.0 -0.35
BXH9/TyJ m 363121.0 0.0   1   0.0 0.0 363121.0, 363121.0 0.49
C3H/HeJ m 470608.0 135154.0   2   95568.0 0.287 375040.0, 566176.0 1.12
C57BL/6J m 289701.0 97891.0   5 43778.0 0.338 202173.0, 416880.0 0.06
C57L/J m 287209.0 0.0   1   0.0 0.0 287209.0, 287209.0 0.04
C58/J m 219201.0 0.0   1   0.0 0.0 219201.0, 219201.0 -0.35
CAST/EiJ m 1793814.0 0.0   1   0.0 0.0 1793814.0, 1793814.0 8.87
CBA/J m 305266.0 0.0   1   0.0 0.0 305266.0, 305266.0 0.15
CE/J m 396170.0 0.0   1   0.0 0.0 396170.0, 396170.0 0.68
CXB11/HiAJ m 351962.0 182940.0   2   129358.0 0.52 222604.0, 481320.0 0.42
CXB12/HiAJ m 165440.0 15470.0   2   10939.0 0.0935 154501.0, 176380.0 -0.67
CXB13/HiAJ m 305887.0 36330.0   3 20975.0 0.119 264522.0, 332619.0 0.15
CXB1/ByJ m 402218.0 100948.0   3 58282.0 0.251 292244.0, 490668.0 0.72
CXB2/ByJ m 450210.0 72955.0   3 42121.0 0.162 380755.0, 526223.0 1.0
CXB3/ByJ m 185490.0 52814.0   2   37345.0 0.285 148145.0, 222835.0 -0.55
CXB4/ByJ m 306415.0 64423.0   2   45554.0 0.21 260861.0, 351969.0 0.16
CXB6/ByJ m 365546.0 61659.0   3 35599.0 0.169 324164.0, 436412.0 0.5
CXB7/ByJ m 287006.0 80229.0   2   56731.0 0.28 230275.0, 343737.0 0.04
CXB8/HiAJ m 275848.0 41665.0   3 24056.0 0.151 240944.0, 321975.0 -0.02
CXB9/HiAJ m 258086.0 15863.0   3 9159.0 0.0615 240566.0, 271475.0 -0.13
DBA/2J m 246584.0 97550.0   4 48775.0 0.396 154078.0, 341653.0 -0.19
FVB/NJ m 91802.0 0.0   1   0.0 0.0 91802.0, 91802.0 -1.1
I/LnJ m 179056.0 0.0   1   0.0 0.0 179056.0, 179056.0 -0.59
KK/HlJ m 267823.0 0.0   1   0.0 0.0 267823.0, 267823.0 -0.07
LG/J m 321893.0 0.0   1   0.0 0.0 321893.0, 321893.0 0.25
LP/J m 369105.0 0.0   1   0.0 0.0 369105.0, 369105.0 0.52
MA/MyJ m 143435.0 0.0   1   0.0 0.0 143435.0, 143435.0 -0.8
NOD/ShiLtJ m 213336.0 0.0   1   0.0 0.0 213336.0, 213336.0 -0.39
NON/ShiLtJ m 344880.0 0.0   1   0.0 0.0 344880.0, 344880.0 0.38
NZW/LacJ m 306588.0 0.0   1   0.0 0.0 306588.0, 306588.0 0.16
PL/J m 252799.0 0.0   1   0.0 0.0 252799.0, 252799.0 -0.16
RIIIS/J m 249894.0 0.0   1   0.0 0.0 249894.0, 249894.0 -0.17
SEA/GnJ m 229419.0 0.0   1   0.0 0.0 229419.0, 229419.0 -0.29
SJL/J m 143630.0 0.0   1   0.0 0.0 143630.0, 143630.0 -0.8
SM/J m 297726.0 0.0   1   0.0 0.0 297726.0, 297726.0 0.11
SWR/J m 191412.0 0.0   1   0.0 0.0 191412.0, 191412.0 -0.52


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J m 332558.75 57267.8756 448941.0758 216176.4242
AXB19b/PgnJ m 246813.55 57267.8756 363195.8758 130431.2242
AXB24/PgnJ m 216878.95 57267.8756 333261.2758 100496.6242
BALB/cJ m 323682.4333 46759.0246 418708.2044 228656.6623
BXA16/PgnJ m 255005.4 57267.8756 371387.7258 138623.0742
BXD19/TyJ m 192383.7 57267.8756 308766.0258 76001.3742
BXD28/TyJ m 205262.5 57267.8756 321644.8258 88880.1742
BXH4/TyJ m 204760.25 57267.8756 321142.5758 88377.9242
C3H/HeJ m 470608.15 57267.8756 586990.4758 354225.8242
C57BL/6J m 289701.06 36219.3847 363307.7058 216094.4142
CXB11/HiAJ m 351962.35 57267.8756 468344.6758 235580.0242
CXB12/HiAJ m 165440.35 57267.8756 281822.6758 49058.0242
CXB13/HiAJ m 305887.4 46759.0246 400913.1711 210861.6289
CXB1/ByJ m 402218.0333 46759.0246 497243.8044 307192.2623
CXB2/ByJ m 450210.0667 46759.0246 545235.8377 355184.2956
CXB3/ByJ m 185490.05 57267.8756 301872.3758 69107.7242
CXB4/ByJ m 306414.95 57267.8756 422797.2758 190032.6242
CXB6/ByJ m 365545.9 46759.0246 460571.6711 270520.1289
CXB7/ByJ m 287006.1 57267.8756 403388.4258 170623.7742
CXB8/HiAJ m 275847.6333 46759.0246 370873.4044 180821.8623
CXB9/HiAJ m 258086.0 46759.0246 353111.7711 163060.2289
DBA/2J m 246583.6 40494.5032 328878.3318 164288.8682




  GWAS USING LINEAR MIXED MODELS