Tsaih1: QTL mapping in recombinant inbred intercross (RIX) hybrids (2005)

Tsaih SW, Lu L, Airey DC, Williams RW, Churchill GA. Quantitative trait mapping in a diallel cross of recombinant inbred lines. Mamm Genome. 2005 May;16(5):344-55.   PubMed 16104382  


       
We describe and test a method of analysis, based on a linear mixed model, that accounts for the correlation structure of recombinant inbred intercross (RIX) populations. For detailed information see Tsaih et al 2005. The original file only had genotypes of CxB RI lines. Author used her own R function to impute RIX genotypes from RI lines.

Note on studied population: inbred intercross (RIX) hybrids

Procedures conducted:
• study archive  Brain weight, body weight.

Tsaih1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators Sharon W Tsaih
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Lu L, Airey DC, Williams RW
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported by the National Institutes of Health (NIH) grants HL55001 and GM070683 and NIMH, NIDA and NSFI grant P20-MH62009. Additional support for this work was provided by the Department of the Army, Medical Division, Grant DAMD-LRD.
Project type QTL Archive data set
MPD identifiersTsaih1     MPD:181
Data changelog No updates/corrections.       Initial release date: 10/2009.
QTL data set parameters:
Progenitor strains BALB/cByJ     C57BL/6ByJ    
Cross direction notationSee LineName column in phenotype data set
Cross typeRI intercross
Population size 105 ♀     106 ♂
Notesthe RIX phenotype file has 211 mice; the CxB RI line has 8 mice


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Tsaih1 body weight (none) mean of the body weight in each line  mean_body   18101 QTL population both N=106
Tsaih1 organ weights (none) mean of the brain weight in each line  mean_brain   18102 QTL population both N=106



Project / data set:   Tsaih1     a.k.a. Tsaih_2005
Excel file:   Data_Description_RIX_Tsaih2005.xlsx
CSV file:   Tsaih2005_B37_pheno_RIX.csv
Readme / text file:   Tsaih2005_B37_geno_RI.txt
Readme / text file:   Tsaih2005_B37_map.txt
Readme / text file:   readme_Tsaih2005.txt