Bouma1: Gonadal and sex research in a backcross of Dax1 XY mice (2005)

Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM. Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development. 2005 Jul;132(13):3045-54.   PubMed 15944188  


       
The nuclear receptor transcription factor Dax1 is hypothesized to play a role in testicular development. A backcross with mutant Dax1 was generated to identify the function of the gene. 128 male mice were measured for fetal gonads and given different scores based on that. The scores were used to do QTL analysis to test the hypothesis. For detailed protocols see Bouma et al, 2005.

Note on studied population: Dax1 XY backcross

Procedures conducted:
• study archive  Fetal gonads microscopy study.

Bouma1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators G J Bouma
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Albrecht KH, Washburn LL, Recknagel AK, Eicher EM
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThis study was supported by NIH grants GM20919 (E.M.E.), HD07065-25 (G.J.B.), GM070683(G.A.C.) and HD042779 (K.H.A.), and NCI core grant CA34196 (The Jackson Laboratory).
Project type QTL Archive data set
MPD identifiersBouma1     MPD:159
Data changelog No updates/corrections.       Initial release date: 04/2010.
QTL data set parameters:
Progenitor strains B6-Dax1-/+     B6-Dax1+/Y     DBA/2J    
Cross direction notation(B6 Dax1-/+ x D2) F1 x B6-Dax1+/Y
Cross typeBackcross
Population size 0 ♀     148 ♂
Notes148 Dax1-/Y mice


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.



Project / data set:   Bouma1     a.k.a. Bouma_2005
Excel file:   Data_Description_BxDbackcross_Bouma2005.xlsx
CSV file:   Bouma2005_BxD_B37_Data.csv
Readme / text file:   ._readme.txt
Readme / text file:   readme_Bouma2005.txt
QC plots, figures, etc.:   QCReport_Bouma2005.pdf