Bailey1: Identification of QTL for locomotor activation and anxiety using related inbred strains C57BL/6J and C58/J (2008)

Bailey JS, Grabowski-Boase L, Steffy BM, Wiltshire T, Churchill GA, Tarantino LM. Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains. Genes Brain Behav. 2008 Oct;7(7):761-9.   PubMed 19130624  


       
Bailey1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants J S Bailey
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
With: Grabowski-Boase L, Steffy BM, Wiltshire T, Tarantino LM
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsResearch described in this article was supported by a Novartis Grant SFP-1407 and funding from the NIH NIDA Grant DA 022392 to L.M.T.
Project type QTL Archive data set
MPD identifiersBailey1     MPD:207
Data changelog No updates/corrections.       Initial release date: 10/2009.
An intercross of similar inbred mouse strains, C57BL/6J and C58/J, was carried out as a control cross for a mutagenesis mapping study in behavior research. The authors identified significant QTL in F2 progeny. The locus on Chr 8 and its interaction effect form the core set of QTL controlling activation and anxiety behaviors, with additional loci on Chr 1 and 6 present in a subset of the behaviors. Mice were assessed using the open field test.


QTL data set parameters:
Progenitor strains C57BL/6J     C58/J    
Cross direction notation(B6xC58/J) F1 x (B6xC58/J) F1
Cross typeF2 intercross
Population size 196 ♀     166 ♂
Age8wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Lacanx1   Lacanx2   Lacanx3   Lacanx4  


Project / data set:   Bailey1     a.k.a. Bailey_2008
Excel file:   Data_Description_B6xC58J_Bailey2008.xlsx
CSV file:   Bailey2008_B6xC58J_B37_Data.csv
Readme / text file:   readme_Bailey2008.txt
QC plots, figures, etc.:   QCReport_Bailey2008.pdf