MPD: Data set: Burke1

Burke1: Dissection of complex adult traits in a mouse synthetic population (2012)

Burke DT, Kozloff KM, Chen S, West JL, Wilkowski JM, Goldstein SA, Miller RA, Galecki AT. Dissection of complex adult traits in a mouse synthetic population. Genome Res. 2012 Aug;22(8):1549-57. doi: 10.1101/gr.135582.11Epub 2012 May 15. PubMed 22588897 FullText

To study causative genetic variations that underlie the complex adult traits, QTL analyses were conducted in 4-way cross population between inbred strains BALB/cJ and C57BL/6J, C3H/HeJ and DBA/2J. Two data sets have been used in the research. The first one was a modest-sized population of 505 female mice, the 2nd one was merged from the initial population and a replicate population. For detailed protocols see the publication of Burke et al (2012).

Note on studied population: (BALBxB6) F1 x (C3HxDBA/2) F1

Procedures conducted:

• study archive

Femur and vertebra morphology and strength. Monthly body weight 3 - 13 months.

Burke1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Burke1 measures:

MA:0000309 vertebra
MA:0001359 femur
MP:0000137 abnormal vertebrae morphology
MP:0000559 abnormal femur morphology
MP:0001259 abnormal body weight
MP:0001542 abnormal bone strength
MP:0004643 abnormal vertebrae number
VT:0000137 vertebra morphology trait
VT:0000138 vertebra quantity
VT:0001259 body mass
VT:0001542 bone strength trait
VT:0004348 femur length

Investigators	D T Burke Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	West JL, Wilkowski JM, Kozloff KM, Goldstein SA, Chen S, Miller RA, Galecki AT
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Project type	QTL Archive data set
MPD identifiers	Burke1 MPD:263
Data changelog	No updates/corrections. Initial release date: 05/2012.

QTL data set parameters:

Dataset 1: (BALBxB6) F1 x (C3HxDBA/2) F1 Burke1
Progenitor strains	BALB/cJ C3H/HeJ C57BL/6J DBA/2J
Cross direction notation	(BALBxB6) F1 x (C3HxDBA/2) F1
Cross type	4-way cross
Population size	505 ♀ 0 ♂
Notes	4 way cross progeny

Progenitor strains	BALB/cJ C3H/HeJ C57BL/6J DBA/2J
Cross type	None
Population size	None ♀ None ♂

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Burke1	computed tomography	(none)	right femur length [mm] Femur_length 26301	QTL population	f	80wks	N=505

Burke1	computed tomography	(none)	caudal 8 (C8) vertebra length [mm] Vert_length 26302	QTL population	f	80wks	N=505

Burke1	computed tomography	(none)	vertebra bone volume fraction [%] Vert_BVF 26303	QTL population	f	80wks	N=505

Burke1	computed tomography	(none)	vertebra trabecular plate number, number of trabeculae per mm along a cross-sectional line of the CT scan of the vertebral bone [n] Vert_TPN 26304	QTL population	f	80wks	N=505

Burke1	biomechanical test	(none)	vertebra mechanical load at breaking [N] Vert_Ult_Load 26305	QTL population	f	80wks	N=505

Burke1	body weight	(none)	weight at 3 months [g] wt_mon3 26306	QTL population	f	14wks	N=505

Burke1	body weight	(none)	weight at 4 months [g] wt_mon4 26307	QTL population	f	18wks	N=505

Burke1	body weight	(none)	weight at 5 months [g] wt_mon5 26308	QTL population	f	22wks	N=505

Burke1	body weight	(none)	weight at 6 months [g] wt_mon6 26309	QTL population	f	27wks	N=505

Burke1	body weight	(none)	weight at 7 months [g] wt_mon7 26310	QTL population	f	31wks	N=505

Burke1	body weight	(none)	weight at 8 months [g] wt_mon8 26311	QTL population	f	35wks	N=505

Burke1	body weight	(none)	weight at 9 months [g] wt_mon9 26312	QTL population	f	38wks	N=505

Burke1	body weight	(none)	weight at 10 months [g] wt_mon10 26313	QTL population	f	45wks	N=505

Burke1	body weight	(none)	weight at 11 months [g] wt_mon11 26314	QTL population	f	48wks	N=505

Burke1	body weight	(none)	weight at 12 months [g] wt_mon12 26315	QTL population	f	52wks	N=505

Burke1	body weight	(none)	weight at 13 months [g] wt_mon13 26316	QTL population	f	56wks	N=505

Burke1	body weight	(none)	best-fit linear weight change 3-13 months (7 values required) wt_slope 26317	QTL population	f	56wks	N=505

Burke1	computed tomography	(none)	right femur length [mm] Femur_length_b 26801	QTL population	f	80wks	N=832

To see more rows use the paging control at top.

Dataset 1: (BALBxB6) F1 x (C3HxDBA/2) F1 Burke1 a.k.a. Burke_2012
Excel file: Data_Description_4way_Burke2012.xlsx
Excel file: Data_Description_4way_Burke2012b.xlsx
CSV file: Burke2012_4way_B37_Data.csv
CSV file: Burke2012b_4way_B37_Data.csv
Readme / text file: readme_Burke2012.txt
Readme / text file: readme_Burke2012b.txt
QC plots, figures, etc.: QCReport_Burke2012.pdf.gz
QC plots, figures, etc.: QCReport_Burke2012b.pdf.gz

Project / data set: Burke1b a.k.a. None

QTL file list not available on this MPD instance.