MPD: Data set: Burke1

Burke1: Dissection of complex adult traits in a mouse synthetic population (2012)

Burke DT, Kozloff KM, Chen S, West JL, Wilkowski JM, Goldstein SA, Miller RA, Galecki AT. Dissection of complex adult traits in a mouse synthetic population. Genome Res. 2012 Aug;22(8):1549-57. doi: 10.1101/gr.135582.11Epub 2012 May 15. PubMed 22588897 FullText

Burke1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Burke1 measures:

MA:0000309 vertebra
MA:0001359 femur
MP:0000137 abnormal vertebrae morphology
MP:0000559 abnormal femur morphology
MP:0001259 abnormal body weight
MP:0001542 abnormal bone strength
MP:0004643 abnormal vertebrae number
VT:0000137 vertebra morphology trait
VT:0000138 vertebra quantity
VT:0001259 body mass
VT:0001542 bone strength trait
VT:0004348 femur length

Investigators	D T Burke Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	West JL, Wilkowski JM, Kozloff KM, Goldstein SA, Chen S, Miller RA, Galecki AT
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Project type	QTL Archive data set
MPD identifiers	Burke1 MPD:263
Data changelog	No updates/corrections. Initial release date: 05/2012.

To study causative genetic variations that underlie the complex adult traits, QTL analyses were conducted in 4-way cross population between inbred strains BALB/cJ and C57BL/6J, C3H/HeJ and DBA/2J. Two data sets have been used in the research. The first one was a modest-sized population of 505 female mice, the 2nd one was merged from the initial population and a replicate population. For detailed protocols see the publication of Burke et al (2012).

QTL data set parameters:

Dataset 1: (BALBxB6) F1 x (C3HxDBA/2) F1 Burke1
Progenitor strains	BALB/cJ C3H/HeJ C57BL/6J DBA/2J
Cross direction notation	(BALBxB6) F1 x (C3HxDBA/2) F1
Cross type	4-way cross
Population size	505 ♀ 0 ♂
Notes	4 way cross progeny

Dataset 2: (BALBxB6) F1 x (C3HxDBA/2) F1 Burke1b
Progenitor strains	BALB/cJ C3H/HeJ C57BL/6J DBA/2J
Cross direction notation	(BALBxB6) F1 x (C3HxDBA/2) F1
Cross type	4-way cross
Population size	832 ♀ 0 ♂
Notes	4 way cross progeny

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Burke1	computed tomography	(none)	right femur length [mm] Femur_length 26301	QTL population	f	80wks	N=505

Burke1	computed tomography	(none)	caudal 8 (C8) vertebra length [mm] Vert_length 26302	QTL population	f	80wks	N=505

Burke1	computed tomography	(none)	vertebra bone volume fraction [%] Vert_BVF 26303	QTL population	f	80wks	N=505

Burke1	computed tomography	(none)	vertebra trabecular plate number, number of trabeculae per mm along a cross-sectional line of the CT scan of the vertebral bone [n] Vert_TPN 26304	QTL population	f	80wks	N=505

Burke1	biomechanical test	(none)	vertebra mechanical load at breaking [N] Vert_Ult_Load 26305	QTL population	f	80wks	N=505

Burke1	body weight	(none)	weight at 3 months [g] wt_mon3 26306	QTL population	f	14wks	N=505

Burke1	body weight	(none)	weight at 4 months [g] wt_mon4 26307	QTL population	f	18wks	N=505

Burke1	body weight	(none)	weight at 5 months [g] wt_mon5 26308	QTL population	f	22wks	N=505

Burke1	body weight	(none)	weight at 6 months [g] wt_mon6 26309	QTL population	f	27wks	N=505

Burke1	body weight	(none)	weight at 7 months [g] wt_mon7 26310	QTL population	f	31wks	N=505

Burke1	body weight	(none)	weight at 8 months [g] wt_mon8 26311	QTL population	f	35wks	N=505

Burke1	body weight	(none)	weight at 9 months [g] wt_mon9 26312	QTL population	f	38wks	N=505

Burke1	body weight	(none)	weight at 10 months [g] wt_mon10 26313	QTL population	f	45wks	N=505

Burke1	body weight	(none)	weight at 11 months [g] wt_mon11 26314	QTL population	f	48wks	N=505

Burke1	body weight	(none)	weight at 12 months [g] wt_mon12 26315	QTL population	f	52wks	N=505

Burke1	body weight	(none)	weight at 13 months [g] wt_mon13 26316	QTL population	f	56wks	N=505

Burke1	body weight	(none)	best-fit linear weight change 3-13 months (7 values required) wt_slope 26317	QTL population	f	56wks	N=505

Burke1	computed tomography	(none)	right femur length [mm] Femur_length_b 26801	QTL population	f	80wks	N=832

To see more rows use the paging control at top.

Dataset 1: (BALBxB6) F1 x (C3HxDBA/2) F1 Burke1 a.k.a. Burke_2012
Excel file: Data_Description_4way_Burke2012.xlsx
Excel file: Data_Description_4way_Burke2012b.xlsx
CSV file: Burke2012_4way_B37_Data.csv
CSV file: Burke2012b_4way_B37_Data.csv
Readme / text file: readme_Burke2012.txt
Readme / text file: readme_Burke2012b.txt
QC plots, figures, etc.: QCReport_Burke2012.pdf.gz
QC plots, figures, etc.: QCReport_Burke2012b.pdf.gz

Dataset 2: (BALBxB6) F1 x (C3HxDBA/2) F1 Burke1b a.k.a. Burke_2012b
Excel file: Data_Description_4way_Burke2012b.xlsx
CSV file: Burke2012b_4way_B37_Data.csv
Readme / text file: readme_Burke2012b.txt
QC plots, figures, etc.: QCReport_Burke2012b.pdf.gz