MPD: Data set: Reifsnyder1

Reifsnyder1: Age-related body weight and composition, plasma glucose, insulin, leptin and lipids in backcross mice (involving NZO/HlLtJ and NON/ShiLtJ) (2000)

Reifsnyder PC, Churchill G, Leiter EH. Maternal environment and genotype interact to establish diabesity in mice. Genome Res. 2000 Oct;10(10):1568-78. PubMed 11042154

Su Z, Ishimori N, Chen Y, Leiter EH, Churchill GA, Paigen B, Stylianou IM. Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene. J Lipid Res. 2009 Oct;50(10):2083-94. Epub 2009 May 12. PubMed 19436067

Reifsnyder1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Reifsnyder1 measures:

MA:0002481 fat pad
MA:0002501 plasma
MA:0002548 inguinal fat pad
MP:0000180 abnormal circulating cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0000188 abnormal circulating glucose level
MP:0001259 abnormal body weight
MP:0001560 abnormal circulating insulin level
MP:0005334 abnormal fat pad morphology
MP:0005336 abnormal inguinal fat pad morphology
MP:0005457 abnormal percent body fat/body weight
MP:0008903 abnormal mesenteric fat pad morphology
MP:0011969 abnormal circulating triglyceride level
MP:0020182 abnormal body mass index
VT:0000180 blood cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0000188 blood glucose amount
VT:0001259 body mass
VT:0001560 blood insulin amount
VT:0002644 blood triglyceride amount
VT:0005334 fat pad morphology trait
VT:0010424 inguinal fat pad mass
VT:0010427 mesenteric fat pad mass
VT:0010482 body fat mass

Investigators	Peter C Reifsnyder The Jackson Laboratory, Bar Harbor, ME
Participants	Churchill G, Leiter EH
Contact	Peter C Reifsnyder peter.reifsnyder@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Research was supported by National Institutes of Health-National Center for Research Resources 88911. Institutional shared services were supported by National Cancer Institute Center Support Grant CA34196. Also funded by US National Institutes of Health grants to B.P. (HL-81162, HL-74086, and HL-77796) and GM-070683 to G.A.C., by American Heart Association Grant 0725905T to Z.S., and by the Novartis Institutes for Biomedical Research.
Project type	QTL Archive data set
MPD identifiers	Reifsnyder1 MPD:111
Data changelog	No updates/corrections. Initial release date: 10/2009.

To identify diabetes-predisposing QTLs, NZO/HlLtJ mice (obese, diabetes-prone) were outcrossed with NONShiLtJ mice (non-obese, non-diabetic) to generate F1 hybrids. F1s of both sexes were backcrossed (reciprocal) with NON/ShiLtJ. Various parameters were tested from 4-24 wks of age. Body weight, plasma glucose, insulin, and, leptin were measured in four-week intervals, and fat pads were harvested at 24 wks of age. For detailed protocols, see Reifsnyder et al 2000.

QTL data set parameters:

Progenitor strains	NON/ShiLtJ NZO/HlLtJ
Cross direction notation	(NZOxNON) x NON; (NONxNZO) x NON;NON x (NZOxNON); NON x (NONxNZO)
Cross type	Reciprocal backcross
Population size	0 ♀ 204 ♂

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Reifsnyder1	body weight	(none)	body weight, 4 wks [g] bw_4 11101	QTL population	m	4wks	N=204

Reifsnyder1	body weight	(none)	body weight, 8 wks [g] bw_8 11102	QTL population	m	8wks	N=204

Reifsnyder1	body weight	(none)	body weight, 12 wks [g] bw_12 11103	QTL population	m	12wks	N=204

Reifsnyder1	body weight	(none)	body weight, 16 wks [g] bw_16 11104	QTL population	m	16wks	N=204

Reifsnyder1	body weight	(none)	body weight, 20 wks [g] bw_20 11105	QTL population	m	20wks	N=204

Reifsnyder1	body weight	(none)	body weight, 24 wks [g] bw_24 11106	QTL population	m	24wks	N=204

Reifsnyder1	metabolic panel	(none)	glucose (plasma), 16 wks [mg/dL] GLU_16 11107	QTL population	m	16wks	N=204

Reifsnyder1	metabolic panel	(none)	glucose (plasma), 16 wks, log transformed [log(mg/dL)] log_GLU_16 11108	QTL population	m	16wks	N=204

Reifsnyder1	metabolic panel	(none)	glucose (plasma), 20 wks [mg/dL] GLU_20 11109	QTL population	m	20wks	N=204

Reifsnyder1	metabolic panel	(none)	glucose (plasma), 20 wks, log transformed [log(mg/dL)] log_GLU_20 11110	QTL population	m	20wks	N=204

Reifsnyder1	metabolic panel	(none)	glucose (plasma), 24 wks [mg/dL] GLU_24 11111	QTL population	m	24wks	N=204

Reifsnyder1	metabolic panel	(none)	glucose (plasma), 24 wks, log transformed [log(mg/dL)] log_GLU_24 11112	QTL population	m	24wks	N=204

Reifsnyder1	hormone quantification	(none)	insulin (plasma), 16 wks [ng/mL] INS_16 11113	QTL population	m	16wks	N=204

Reifsnyder1	hormone quantification	(none)	insulin (plasma), 20 wks [ng/mL] INS_20 11114	QTL population	m	20wks	N=204

Reifsnyder1	hormone quantification	(none)	insulin (plasma), 24 wks [ng/mL] INS_24 11115	QTL population	m	24wks	N=204

Reifsnyder1	hormone quantification	(none)	leptin, 24 wks [ng/mL] LEP_24 11116	QTL population	m	24wks	N=204

Reifsnyder1	fat pad weights	(none)	inguinal fat pad weight [g] inguinal_fat 11117	QTL population	m	24wks	N=204

Reifsnyder1	fat pad weights	(none)	retroperitoneal fat pad weight at [g] peritoneal_fat 11118	QTL population	m	24wks	N=204

Reifsnyder1	fat pad weights	(none)	mesenteric fat pad weight [g] mesenteric_fat 11119	QTL population	m	24wks	N=204

Reifsnyder1	fat pad weights	(none)	total fat pad weight [g] total_fat 11120	QTL population	m	24wks	N=204

Reifsnyder1	fat pad weights	(none)	percentage of body weight that is attributed to fat pads [%] pct_fat 11121	QTL population	m	24wks	N=204

Reifsnyder1	body weight	(none)	body mass index (BMI) [g/cm²] BMI 11122	QTL population	m	24wks	N=204

Reifsnyder1	lipid profile	(none)	plasma triglyceride concentration [mg/dL] TG 11123	QTL population	m	24wks	N=204

Reifsnyder1	lipid profile	(none)	plasma HDL concentration [mg/dL] HDLD 11124	QTL population	m	24wks	N=204

Reifsnyder1	lipid profile	(none)	plasma total cholesterol concentration [mg/dL] Chol 11125	QTL population	m	24wks	N=204

To see more rows use the paging control at top.

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Dbsty1 Dbsty2 Dbsty3 Dbsty4 Hdlq11 Hdlq15 Hdlq16 Hdlq21 Hdlq48 Hdlq63 Hdlq64 Hdlq68 Hdlq69 Hdlq7 Hdlq71 Hdlq72 Hdlq73 Hdlq74 Hdlq75 Hdlq76 Hdlq77 Tcq3 Tcq4 Tcq5 Tcq6 Tcq7 Tcq8 Tcq9 Tgq30 Tgq31 Tgq32 Tgq33 Tgq34 Tgq4 Tgq5 Tgq6

Project / data set: Reifsnyder1 a.k.a. Reifsnyder_2000
Excel file: Data_Description_NZOxNON_Reifsnyder2000.xlsx
CSV file: Reifsnyder2000_NZOxNON_B37_Data.csv
Readme / text file: readme_Reifsnyder2000.txt