Reifsnyder1: Age-related body weight and composition, plasma glucose, insulin, leptin and lipids in backcross mice (involving NZO/HlLtJ and NON/ShiLtJ) (2000)

Reifsnyder PC, Churchill G, Leiter EH. Maternal environment and genotype interact to establish diabesity in mice. Genome Res. 2000 Oct;10(10):1568-78.   PubMed 11042154  

Su Z, Ishimori N, Chen Y, Leiter EH, Churchill GA, Paigen B, Stylianou IM. Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene. J Lipid Res. 2009 Oct;50(10):2083-94. Epub 2009 May 12.   PubMed 19436067  


       
To identify diabetes-predisposing QTLs, NZO/HlLtJ mice (obese, diabetes-prone) were outcrossed with NONShiLtJ mice (non-obese, non-diabetic) to generate F1 hybrids. F1s of both sexes were backcrossed (reciprocal) with NON/ShiLtJ. Various parameters were tested from 4-24 wks of age. Body weight, plasma glucose, insulin, and, leptin were measured in four-week intervals, and fat pads were harvested at 24 wks of age. For detailed protocols, see Reifsnyder et al 2000.

Note on studied population: NZO/HlLtJ x NON/ShiLtJ backcross

Procedures conducted:
• study archive  Body weight (several ages), fat mass, body mass index, fat pad weights.

Reifsnyder1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Investigators Peter C Reifsnyder       The Jackson Laboratory,  Bar Harbor, ME
Participants Churchill G, Leiter EH
ContactPeter C Reifsnyder     peter.reifsnyder@jax.org
Affiliated CenterQTL Archive
AcknowledgementsResearch was supported by National Institutes of Health-National Center for Research Resources 88911. Institutional shared services were supported by National Cancer Institute Center Support Grant CA34196. Also funded by US National Institutes of Health grants to B.P. (HL-81162, HL-74086, and HL-77796) and GM-070683 to G.A.C., by American Heart Association Grant 0725905T to Z.S., and by the Novartis Institutes for Biomedical Research.
Project type QTL Archive data set
MPD identifiersReifsnyder1     MPD:111
Data changelog No updates/corrections.       Initial release date: 10/2009.
QTL data set parameters:
Progenitor strains NON/ShiLtJ     NZO/HlLtJ    
Cross direction notation(NZOxNON) x NON; (NONxNZO) x NON;NON x (NZOxNON); NON x (NONxNZO)
Cross typeReciprocal backcross
Population size 0 ♀     204 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Dbsty1   Dbsty2   Dbsty3   Dbsty4   Hdlq11   Hdlq15   Hdlq16   Hdlq21   Hdlq48   Hdlq63   Hdlq64   Hdlq68   Hdlq69   Hdlq7   Hdlq71   Hdlq72   Hdlq73   Hdlq74   Hdlq75   Hdlq76   Hdlq77   Tcq3   Tcq4   Tcq5   Tcq6   Tcq7   Tcq8   Tcq9   Tgq30   Tgq31   Tgq32   Tgq33   Tgq34   Tgq4   Tgq5   Tgq6  


Project / data set:   Reifsnyder1     a.k.a. Reifsnyder_2000
Excel file:   Data_Description_NZOxNON_Reifsnyder2000.xlsx
CSV file:   Reifsnyder2000_NZOxNON_B37_Data.csv
Readme / text file:   readme_Reifsnyder2000.txt