Leiter2: NOD x 129.H2g7 backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice (2009)
Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC. NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice.
Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31.
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| Participants |
Ed Leiter The Jackson Laboratory Bar Harbor, ME With: Reifsnyder PC, Wallace R, Li R, King B, Churchill GC |
| Contact | Ed Leiter ed.leiter@jax.org |
| Affiliation | Churchill Group QTL Archive |
| Acknowledgements | This work was supported by grants NIH-RR09781 and DK75000 (E.H.L.) and GM070683 (G.C.C.). Institutional shared services were supported by NCI Center Support Grant CA34196. |
| QTL Archive data set | |
| MPD identifiers | Leiter2 MPD:240 |
| No updates/corrections. Initial release date: 01/2008. |
A backcross of NOD × (NOD × 129.H2g7) was generated to identify 129S1/SvJ non-MHC regions contributing to type 1 diabetes development. A genome scan for QTLs affecting clinical diabetes, age of diabetes onset, and insulitis severity was performed for detection of diabetes susceptibility loci in 310 female mice from this cross. For detailed information see Leiter et al 2009.
| Progenitor strains | 129S1/Sv.NOD-H2g7 NOD/ShiLtJ |
| Cross direction notation | NOD x (NOD x 129.H2g7) |
| Cross type | Backcross |
| Population size | 310 ♀ 0 ♂ |
| Notes | N2 progeny |
| Data set | MPD ID | Procedure / Protocol | Drug or Challenge | Phenotype Measure | Panel | No. of Strains | Sex | Age | Sample Size (Avg) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 24001 | health assessment | (none) | age of diabetes onset (dash = no diabetes) [wks] Onset | QTL population | f | 14-40wks | N=310 | ||||||
| 24002 | health assessment | (none) | 1 = diabetes, 0 = no diabetes [score] DB1_0 | QTL population | f | 14-40wks | N=310 | ||||||
| 24003 | histopathology | (none) | combination score of age at type 1 diabetes onset, and insulitis severity / extent (see excel file) [score] Insulities_TimeOnset | QTL population | f | 14-40wks | N=310 | ||||||
| 24004 | histopathology | (none) | insulitis severity / extent score (0-4, see excel file) [score] Insulitis | QTL population | f | 14-40wks | N=310 | ||||||
| 24005 | histopathology | (none) | group mice by insulitis score (0-3, see excel file) [score] GroupInsulitis_Diabetes | QTL population | f | 14-40wks | N=310 | ||||||
| 24006 | body weight | (none) | body weight at 30 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row) [g] 30wk | QTL population | f | 30wks | N=310 | ||||||
| 24007 | body weight | (none) | body weight at 40 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row) [g] 40wk | QTL population | f | 40wks | N=310 | ||||||
| 24008 | body weight | (none) | body Weight of whole mouse at time of DXA [g] BW | QTL population | f | 14-40wks | N=310 | ||||||
| 24009 | DXA | (none) | bone Mineral Density, as determined by DXA (Dual emission X-ray Absorptiometry, head excluded) [g/cm2] BMD | QTL population | f | 14-40wks | N=310 | ||||||
| 24010 | DXA | (none) | bone Mineral Content, as determined by DXA [g] BMC | QTL population | f | 14-40wks | N=310 | ||||||
| 24011 | DXA | (none) | bone Mineral Area, as determined by DXA [cm2] Area | QTL population | f | 14-40wks | N=310 | ||||||
| 24012 | DXA | (none) | weight of muscle and organs, as determined by DXA [g] Lean | QTL population | f | 14-40wks | N=310 | ||||||
| 24013 | DXA | (none) | weight of fat, as determined by DXA [g] Fat | QTL population | f | 14-40wks | N=310 | ||||||
| 24014 | DXA | (none) | total weight, as determined by DXA [g] Total | QTL population | f | 14-40wks | N=310 | ||||||
| 24015 | DXA | (none) | percentage of fat of total weight as determined by DXA [%] %Fat | QTL population | f | 14-40wks | N=310 | ||||||
| 24016 | hormone quantification | (none) | leptin in plasma [ng/mL] Leptin | QTL population | f | 14-40wks | N=310 | ||||||
| 24017 | hormone quantification | (none) | insulin in plasma [ng/mL] Insulin | QTL population | f | 14-40wks | N=310 | ||||||
| 24018 | lipid profile | (none) | total cholesterol in plasma [mg/dL] CHOL | QTL population | f | 14-40wks | N=310 | ||||||
| 24019 | lipid profile | (none) | HDLD cholesterol in plasma [mg/dL] HDLD | QTL population | f | 14-40wks | N=310 | ||||||
| 24020 | metabolic panel | (none) | glucose in plasma [mg/dL] Glucose | QTL population | f | 14-40wks | N=310 | ||||||
| 24021 | lipid profile | (none) | non-Esterified Fatty Acids in plasma [mEq/L] NEFA | QTL population | f | 14-40wks | N=310 | ||||||
| 24022 | lipid profile | (none) | triglycerides in plasma [mg/dL] TG | QTL population | f | 14-40wks | N=310 | ||||||
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Project / data set: Leiter2 a.k.a. Leiter_2009
Excel file: Data_Description_NODx129_Leiter2009.xlsx
CSV file: Leiter2009_NODx129_B37_Data.csv
Readme / text file: readme_Leiter2009.txt
QC plots, figures, etc.: QCReport_Leiter2009.pdf