Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC. NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice.
Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31.
Type 1 diabetes development study. |
Investigators |
Ed Leiter The Jackson Laboratory, Bar Harbor, ME |
Participants | Reifsnyder PC, Wallace R, Li R, King B, Churchill GC |
Contact | Ed Leiter ed.leiter@jax.org |
Affiliated Center | QTL Archive |
Acknowledgements | This work was supported by grants NIH-RR09781 and DK75000 (E.H.L.) and GM070683 (G.C.C.). Institutional shared services were supported by NCI Center Support Grant CA34196. |
QTL Archive data set | |
MPD identifiers | Leiter2 MPD:240 |
No updates/corrections. Initial release date: 01/2008. |
Progenitor strains | 129S1/Sv.NOD-H2g7 NOD/ShiLtJ |
Cross direction notation | NOD x (NOD x 129.H2g7) |
Cross type | Backcross |
Population size | 310 ♀ 0 ♂ |
Notes | N2 progeny |
Data set |
Procedure / Protocol |
Treatment |
Phenotype Measure / Variable (click to view) |
Panel |
No. of Strains |
Sex |
Age |
Sample Size (Avg)
|
||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
health assessment | (none) | age of diabetes onset (dash = no diabetes) [wks] Onset 24001 | QTL population | f | N=310 | |||||||
health assessment | (none) | 1 = diabetes, 0 = no diabetes [score] DB1_0 24002 | QTL population | f | N=310 | |||||||
histopathology | (none) | combination score of age at type 1 diabetes onset, and insulitis severity / extent (see excel file) [score] Insulities_TimeOnset 24003 | QTL population | f | N=310 | |||||||
histopathology | (none) | insulitis severity / extent score (0-4, see excel file) [score] Insulitis 24004 | QTL population | f | N=310 | |||||||
histopathology | (none) | group mice by insulitis score (0-3, see excel file) [score] GroupInsulitis_Diabetes 24005 | QTL population | f | N=310 | |||||||
body weight | (none) | body weight at 30 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row) [g] 30wk 24006 | QTL population | f | N=310 | |||||||
body weight | (none) | body weight at 40 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row) [g] 40wk 24007 | QTL population | f | N=310 | |||||||
body weight | (none) | body weight of whole mouse at time of DXA [g] BW 24008 | QTL population | f | N=310 | |||||||
DXA | (none) | bone mineral density (BMD), as determined by DXA, head excluded [g/cm2] BMD 24009 | QTL population | f | N=310 | |||||||
DXA | (none) | bone mineral content (BMC), as determined by DXA, head excluded [g] BMC 24010 | QTL population | f | N=310 | |||||||