Leiter2: NOD x 129.H2g7 backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice (2009)

Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC. NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice. Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31.   PubMed 19336673     FullText


     
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Participants Ed Leiter       The Jackson Laboratory Bar Harbor, ME
With: Reifsnyder PC, Wallace R, Li R, King B, Churchill GC
ContactEd Leiter     ed.leiter@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by grants NIH-RR09781 and DK75000 (E.H.L.) and GM070683 (G.C.C.). Institutional shared services were supported by NCI Center Support Grant CA34196.
Project type QTL Archive data set
MPD identifiersLeiter2     MPD:240
Data changelog No updates/corrections.       Initial release date: 01/2008.
A backcross of NOD × (NOD × 129.H2g7) was generated to identify 129S1/SvJ non-MHC regions contributing to type 1 diabetes development. A genome scan for QTLs affecting clinical diabetes, age of diabetes onset, and insulitis severity was performed for detection of diabetes susceptibility loci in 310 female mice from this cross. For detailed information see Leiter et al 2009.


QTL data set parameters:
Progenitor strains 129S1/Sv.NOD-H2g7     NOD/ShiLtJ    
Cross direction notationNOD x (NOD x 129.H2g7)
Cross typeBackcross
Population size 310 ♀     0 ♂
NotesN2 progeny


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.



Project / data set:   Leiter2     a.k.a. Leiter_2009
Excel file:   Data_Description_NODx129_Leiter2009.xlsx
CSV file:   Leiter2009_NODx129_B37_Data.csv
Readme / text file:   readme_Leiter2009.txt
QC plots, figures, etc.:   QCReport_Leiter2009.pdf