MPD: Data set: Leiter2

Leiter2: NOD x 129.H2g7 backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice (2009)

Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC. NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice. Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31. PubMed 19336673 FullText

Leiter2 downloads
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Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Leiter2 measures:
MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0000188 abnormal circulating glucose level
MP:0001259 abnormal body weight
MP:0001553 abnormal circulating free fatty acids level
MP:0001560 abnormal circulating insulin level
MP:0003959 abnormal lean body mass
MP:0005457 abnormal percent body fat/body weight
MP:0005667 abnormal circulating leptin level
MP:0010119 abnormal bone mineral density
MP:0010122 abnormal bone mineral content
MP:0011969 abnormal circulating triglyceride level
MP:0012320 abnormal body fat mass
MP:0012321 abnormal total tissue mass
MP:0020086 abnormal susceptibility to non-insulin-dependent diabetes
VT:0000180 blood cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0000188 blood glucose amount
VT:0001259 body mass
VT:0001553 blood free fatty acid amount
VT:0001560 blood insulin amount
VT:0001764 homeostasis trait
VT:0002644 blood triglyceride amount
VT:0005007 bone mineral mass
VT:0005667 blood leptin amount
VT:0010139 immune response trait
VT:0010482 body fat mass
VT:0010483 body lean mass

Participants	Ed Leiter The Jackson Laboratory, Bar Harbor, ME With: Reifsnyder PC, Wallace R, Li R, King B, Churchill GC
Contact	Ed Leiter ed.leiter@jax.org
Affiliation	Churchill Group QTL Archive
Acknowledgements	This work was supported by grants NIH-RR09781 and DK75000 (E.H.L.) and GM070683 (G.C.C.). Institutional shared services were supported by NCI Center Support Grant CA34196.
Project type	QTL Archive data set
MPD identifiers	Leiter2 MPD:240
Data changelog	No updates/corrections. Initial release date: 01/2008.

A backcross of NOD × (NOD × 129.H2g7) was generated to identify 129S1/SvJ non-MHC regions contributing to type 1 diabetes development. A genome scan for QTLs affecting clinical diabetes, age of diabetes onset, and insulitis severity was performed for detection of diabetes susceptibility loci in 310 female mice from this cross. For detailed information see Leiter et al 2009.

QTL data set parameters:

Progenitor strains	129S1/Sv.NOD-H2g7 NOD/ShiLtJ
Cross direction notation	NOD x (NOD x 129.H2g7)
Cross type	Backcross
Population size	310 ♀ 0 ♂
Notes	N2 progeny

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	MPD ID	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	Sex	Age	Sample Size (Avg)
Leiter2	24001	health assessment	(none)	age of diabetes onset (dash = no diabetes) [wks] Onset	QTL population	f	14-40wks	N=310

Leiter2	24002	health assessment	(none)	1 = diabetes, 0 = no diabetes [score] DB1_0	QTL population	f	14-40wks	N=310

Leiter2	24003	histopathology	(none)	combination score of age at type 1 diabetes onset, and insulitis severity / extent (see excel file) [score] Insulities_TimeOnset	QTL population	f	14-40wks	N=310

Leiter2	24004	histopathology	(none)	insulitis severity / extent score (0-4, see excel file) [score] Insulitis	QTL population	f	14-40wks	N=310

Leiter2	24005	histopathology	(none)	group mice by insulitis score (0-3, see excel file) [score] GroupInsulitis_Diabetes	QTL population	f	14-40wks	N=310

Leiter2	24006	body weight	(none)	body weight at 30 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row) [g] 30wk	QTL population	f	30wks	N=310

Leiter2	24007	body weight	(none)	body weight at 40 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row) [g] 40wk	QTL population	f	40wks	N=310

Leiter2	24008	body weight	(none)	body weight of whole mouse at time of DXA [g] BW	QTL population	f	14-40wks	N=310

Leiter2	24009	DXA	(none)	bone mineral density (BMD), as determined by DXA, head excluded [g/cm²] BMD	QTL population	f	14-40wks	N=310

Leiter2	24010	DXA	(none)	bone mineral content (BMC), as determined by DXA, head excluded [g] BMC	QTL population	f	14-40wks	N=310

Leiter2	24011	DXA	(none)	bone mineral area, as determined by DXA, head excluded [cm²] Area	QTL population	f	14-40wks	N=310

Leiter2	24012	DXA	(none)	weight of muscle and organs, as determined by DXA [g] Lean	QTL population	f	14-40wks	N=310

Leiter2	24013	DXA	(none)	weight of fat, as determined by DXA [g] Fat	QTL population	f	14-40wks	N=310

Leiter2	24014	DXA	(none)	total weight, as determined by DXA [g] Total	QTL population	f	14-40wks	N=310

Leiter2	24015	DXA	(none)	percentage of fat of total weight as determined by DXA [%] %Fat	QTL population	f	14-40wks	N=310

Leiter2	24016	hormone quantification	(none)	leptin in plasma [ng/mL] Leptin	QTL population	f	14-40wks	N=310

Leiter2	24017	hormone quantification	(none)	insulin in plasma [ng/mL] Insulin	QTL population	f	14-40wks	N=310

Leiter2	24018	lipid profile	(none)	total cholesterol in plasma [mg/dL] CHOL	QTL population	f	14-40wks	N=310

Leiter2	24019	lipid profile	(none)	HDLD cholesterol in plasma [mg/dL] HDLD	QTL population	f	14-40wks	N=310

Leiter2	24020	metabolic panel	(none)	glucose in plasma [mg/dL] Glucose	QTL population	f	14-40wks	N=310

Leiter2	24021	lipid profile	(none)	non-Esterified Fatty Acids in plasma [mEq/L] NEFA	QTL population	f	14-40wks	N=310

Leiter2	24022	lipid profile	(none)	triglycerides in plasma [mg/dL] TG	QTL population	f	14-40wks	N=310

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Project / data set: Leiter2 a.k.a. Leiter_2009
Excel file: Data_Description_NODx129_Leiter2009.xlsx
CSV file: Leiter2009_NODx129_B37_Data.csv
Readme / text file: readme_Leiter2009.txt
QC plots, figures, etc.: QCReport_Leiter2009.pdf