Leiter2: NOD x 129.H2g7 backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice (2009)

Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC. NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice. Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31.   PubMed 19336673     FullText


       
A backcross of NOD × (NOD × 129.H2g7) was generated to identify 129S1/SvJ non-MHC regions contributing to type 1 diabetes development. A genome scan for QTLs affecting clinical diabetes, age of diabetes onset, and insulitis severity was performed for detection of diabetes susceptibility loci in 310 female mice from this cross. For detailed information see Leiter et al 2009.

Note on studied population: NOD x 129.H2g7 backcross.

Procedures conducted:
• study archive  Type 1 diabetes development study.

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Investigators Ed Leiter       The Jackson Laboratory,  Bar Harbor, ME
Participants Reifsnyder PC, Wallace R, Li R, King B, Churchill GC
ContactEd Leiter     ed.leiter@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported by grants NIH-RR09781 and DK75000 (E.H.L.) and GM070683 (G.C.C.). Institutional shared services were supported by NCI Center Support Grant CA34196.
Project type QTL Archive data set
MPD identifiersLeiter2     MPD:240
Data changelog No updates/corrections.       Initial release date: 01/2008.
QTL data set parameters:
Progenitor strains 129S1/Sv.NOD-H2g7     NOD/ShiLtJ    
Cross direction notationNOD x (NOD x 129.H2g7)
Cross typeBackcross
Population size 310 ♀     0 ♂
NotesN2 progeny


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Leiter2 health assessment (none) age of diabetes onset (dash = no diabetes)   [wks]  Onset   24001 QTL population f 14-40wks N=310
Leiter2 health assessment (none) 1 = diabetes, 0 = no diabetes   [score]  DB1_0   24002 QTL population f 14-40wks N=310
Leiter2 histopathology (none) combination score of age at type 1 diabetes onset, and insulitis severity / extent (see excel file)   [score]  Insulities_TimeOnset   24003 QTL population f 14-40wks N=310
Leiter2 histopathology (none) insulitis severity / extent score (0-4, see excel file)   [score]  Insulitis   24004 QTL population f 14-40wks N=310
Leiter2 histopathology (none) group mice by insulitis score (0-3, see excel file)   [score]  GroupInsulitis_Diabetes   24005 QTL population f 14-40wks N=310
Leiter2 body weight (none) body weight at 30 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row)   [g]  30wk   24006 QTL population f 30wks N=310
Leiter2 body weight (none) body weight at 40 wks of age (if alive, mice were sacrificed when determined to be diabetic 2 wks in a row)   [g]  40wk   24007 QTL population f 40wks N=310
Leiter2 body weight (none) body weight of whole mouse at time of DXA   [g]  BW   24008 QTL population f 14-40wks N=310
Leiter2 DXA (none) bone mineral density (BMD), as determined by DXA, head excluded   [g/cm2]  BMD   24009 QTL population f 14-40wks N=310
Leiter2 DXA (none) bone mineral content (BMC), as determined by DXA, head excluded   [g]  BMC   24010 QTL population f 14-40wks N=310
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Project / data set:   Leiter2     a.k.a. Leiter_2009
Excel file:   Data_Description_NODx129_Leiter2009.xlsx
CSV file:   Leiter2009_NODx129_B37_Data.csv
Readme / text file:   readme_Leiter2009.txt
QC plots, figures, etc.:   QCReport_Leiter2009.pdf