Pitman1: Plasma HDL cholesterol regulation in backcross progeny involving NZB/BlNJ and SM/J (2002)

Pitman WA, Korstanje R, Churchill GA, Nicodeme E, Albers JJ, Cheung MC, Staton MA, Sampson SS, Harris S, Paigen B. Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice. Physiol Genomics. 2002;9(2):93-102.   PubMed 12006675  


     
Pitman1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants W A Pitman
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Korstanje R, Nicodeme E, Albers JJ, Cheung MC, Staton MA, Sampson SS, Harris S, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH HL32087, HL30086, CA34196; and GlaxoWellcome
Project type QTL Archive data set
MPD identifiersPitman1     MPD:123
Data changelog No updates/corrections.       Initial release date: 01/2008.
A backcross involving NZB/BlNJ and SM/J inbred mouse strains was generated to identify QTLs involved in plasma HDL cholesterol concentrations. Blood lipids were measured in backcross progeny administered a high-fat (15%) diet at 6-8 wks of age. The diet was maintained for 18 wks; mice were tested at regular intervals. Plasma was obtained from fasted mice (4 hr). For detailed protocols see Pitman et al 2002.


QTL data set parameters:
Progenitor strains NZB/BlNJ     SM/J    
Cross direction notation(SM x NZB) x NZB
Cross typeBackcross
Population size 89 ♀     0 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Pitman1 12301 lipid profile (none) HDL cholesterol (plasma)   [mg/dL]  HDL_chow QTL population f 6-8wks N=89
Pitman1 12302 lipid profile high-fat diet HDL cholesterol (plasma)   [mg/dL]  HDL_fat4 QTL population f 10-12wks N=89
Pitman1 12303 lipid profile high-fat diet HDL cholesterol (plasma)   [mg/dL]  HDL_fat8 QTL population f 14-16wks N=89
Pitman1 12304 lipid profile high-fat diet HDL cholesterol (plasma)   [mg/dL]  HDL_fat18 QTL population f 24-26wks N=89
Pitman1 12305 lipid profile (none) total cholesterol (plasma)   [mg/dL]  chol_chow QTL population f 6-8wks N=89
Pitman1 12306 lipid profile high-fat diet total cholesterol (plasma)   [mg/dL]  chol_fat4 QTL population f 10-12wks N=89
Pitman1 12307 lipid profile high-fat diet total cholesterol (plasma)   [mg/dL]  chol_fat8 QTL population f 14-16wks N=89
Pitman1 12308 lipid profile high-fat diet total cholesterol (plasma)   [mg/dL]  chol_fat18 QTL population f 24-26wks N=89

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Hdlq2   Hdlq3   Hdlq4  


Project / data set:   Pitman1     a.k.a. Pitman_2002
Excel file:   Data_Description_SMxNZB_Pitman2002.xlsx
CSV file:   Pitman2002_SMxNZB_B37_Data.csv
Readme / text file:   readme_Pitman2002.txt
QC plots, figures, etc.:   QCReport_Pitman2002.pdf