Mathews1: Genetic analysis of resistance to Type-1 diabetes in ALR/Lt and NOD backcross (2003)

Mathews CE, Graser RT, Bagley RJ, Caldwell JW, Li R, Churchill GA, Serreze DV, Leiter EH. Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress. Immunogenetics. 2003 Oct;55(7):491-6. Epub 2003 Sep 25.   PubMed 14513297  


       
ALR mice are closely related to type-1 diabetes mellitus (T1DM) prone NOD mice (a popular mouse model for type-1 diabetes research), but they do not have an identical haplotype which links to the type-1 diabetes resistance locus. To fine map the Idd16 locus and chromosomal regions carrying other resistance loci, ALR mice were outcrossed to NOD mice to produce 120 backcross female progeny. They were monitored for T1DM from 8 to 40 weeks and the following QTL analysis identified three ALR-derived resistance loci. For detailed protocols see Mathews et al 2003.

Note on studied population: ALR/Lt x NOD backcross

Procedures conducted:
• study archive  Type 1 diabetes resistance.

Mathews1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators C E Mathews
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Graser RT, Bagley RJ, Caldwell JW, Li R, Serreze DV, Leiter EH
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported by the Juvenile Diabetes Research Foundation International, the American Diabetes Association and the National Institutes of Health grants F32DK09889, F32DK09865, DK27722, DK36175, DK46266, and DK51090. Institutional shared services (TJL) were supported by National Cancer Institute Cancer Center Support Grant CA34196.
Project type QTL Archive data set
MPD identifiersMathews1     MPD:134
Data changelog No updates/corrections.       Initial release date: 08/2011.
QTL data set parameters:
Progenitor strains ALR/LtJ     NOD/ShiLtJ    
Cross direction notation(NOD x ALR) x NOD
Cross typeBackcross
Population size 120 ♀     0 ♂
Age8-40wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Mathews1 histopathology (none) Clinical T1DM accompanied by end-stage insulitis before necropsy (score 0=non-diabetes, 1=diabetes)   [score]  IDDM   13401 QTL population f 8-40wks N=120
Mathews1 histopathology (none) severity of diabetes (score 0=non-diabetes, 1=diabetes, 2=severe diabetes)   [score]  IDDM_VS_HI   13402 QTL population f 8-40wks N=120
Mathews1 histopathology (none) Clinical T1DM accompanied by end-stage insulitis diagnosed at necropsy (score 0=non-diabetes, 1=diabetes)   [score]  IDM   13403 QTL population f 8-40wks N=120

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Idd16   Idd22  


Project / data set:   Mathews1     a.k.a. Mathews_2003
Excel file:   Data_Description_ALRxNOD_BC_Mathews2003.xlsx
CSV file:   Mathews2003_ALRxNOD_BC_B37_Data.csv
Readme / text file:   readme_Mathews2003.txt
QC plots, figures, etc.:   QCReport_Mathews2003.pdf