Zhang1: Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice (2012)

Zhang Z, Rowlan JS, Wang Q, Shi W. Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2012 Apr 1;5(2):190-20Epub 2012 Jan 31.   PubMed 22294616     FullText


     
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Participants Z Zhang
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Rowlan JS, Wang Q, Shi W
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsGrant: The research was supported by grants from the National Institutes of Health (AR43618, RR08911-5,CA34196), the US Army (DAMA17-94-J-4016), and the S.D. Bechtel Foundation.
Project type QTL Archive data set
MPD identifiersZhang1     MPD:279
Data changelog No updates/corrections.       Initial release date: 07/2012.
Female F2 mice (n 266) were generated from an intercross between B6.Apoe -/- and BALB.Apoe -/- mice and fed a Western diet for 12 weeks. Atherosclerotic lesions in the aortic root, fasting plasma glucose, and body weight were measured. 130 microsatellite markers across the entire genome were genotyped. Four significant QTLs, Ath1 on chromosome (Chr) 1, Ath41 on Chr2, Ath42 on Chr5, and Ath29 on Chr9, and 1 suggestive QTL on Chr4, were identified for atherosclerotic lesion size. Four significant QTLs, Bglu3 and Bglu12 on Chr1, Bglu13 on Chr5, Bglu15 on Chr12, and 2 suggestive QTLs on Chr9 and Chr15 were identified for fasting glucose levels on the chow diet. Two significant QTLs, Bglu3 and Bglu13, and 1 suggestive locus on Chr8 were identified for fasting glucose on the Western diet. One significant locus on Chr1 and 2 suggestive loci on Chr9 and Chr19 were identified for body weight. Ath1 and Ath42 coincided with Bglu3 and Bglu13, respectively, in the confidence interval.


QTL data set parameters:
Progenitor strains BALB/cJ Apoe-/-     C57BL/6J Apoe-/-    
Cross direction notationboth
Cross typeF2 intercross
Population size 266 ♀     0 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Ath41   Ath42   Bglu12   Bglu13   Bglu14   Bglu15  


Project / data set:   Zhang1     a.k.a. Zhang_2012
Excel file:   Data_Description_BL6xBALB_Zhang2012.xlsx
CSV file:   Zhang2012_BL6xBALB_B37_Data.csv
Readme / text file:   readme_Zhang2012.txt
QC plots, figures, etc.:   QCReport_Zhang2012.pdf