MPD: Data set: Zhang1

Zhang1: Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice (2012)

Zhang Z, Rowlan JS, Wang Q, Shi W. Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2012 Apr 1;5(2):190-20Epub 2012 Jan 31. PubMed 22294616 FullText

Female F2 mice (n 266) were generated from an intercross between B6.Apoe -/- and BALB.Apoe -/- mice and fed a Western diet for 12 weeks. Atherosclerotic lesions in the aortic root, fasting plasma glucose, and body weight were measured. 130 microsatellite markers across the entire genome were genotyped. Four significant QTLs, Ath1 on chromosome (Chr) 1, Ath41 on Chr2, Ath42 on Chr5, and Ath29 on Chr9, and 1 suggestive QTL on Chr4, were identified for atherosclerotic lesion size. Four significant QTLs, Bglu3 and Bglu12 on Chr1, Bglu13 on Chr5, Bglu15 on Chr12, and 2 suggestive QTLs on Chr9 and Chr15 were identified for fasting glucose levels on the chow diet. Two significant QTLs, Bglu3 and Bglu13, and 1 suggestive locus on Chr8 were identified for fasting glucose on the Western diet. One significant locus on Chr1 and 2 suggestive loci on Chr9 and Chr19 were identified for body weight. Ath1 and Ath42 coincided with Bglu3 and Bglu13, respectively, in the confidence interval.

Note on studied population: C57BL/6 x BALB/cJ intercross

Procedures conducted:

• study archive

Atherosclerosis and glucose homeostasis. Lesions, lipids, glucose, insulin. High-fat, western-style diet.

Zhang1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Zhang1 measures:

MA:0000059 blood
MA:0000062 aorta
MA:0000151 skin
MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000181 abnormal circulating LDL cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0000188 abnormal circulating glucose level
MP:0001259 abnormal body weight
MP:0005340 altered susceptibility to atherosclerosis
MP:0005667 abnormal circulating leptin level
MP:0011239 abnormal skin coloration
MP:0011969 abnormal circulating triglyceride level
MP:0020098 abnormal susceptibility to diet-induced aortic fatty streak lesions
VT:0000180 blood cholesterol amount
VT:0000181 blood LDL cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0000188 blood glucose amount
VT:0000272 aorta morphology trait
VT:0001259 body mass
VT:0002095 skin pigmentation trait
VT:0002644 blood triglyceride amount
VT:0005667 blood leptin amount

Investigators	Z Zhang Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Rowlan JS, Wang Q, Shi W
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Grant: The research was supported by grants from the National Institutes of Health (AR43618, RR08911-5,CA34196), the US Army (DAMA17-94-J-4016), and the S.D. Bechtel Foundation.
Project type	QTL Archive data set
MPD identifiers	Zhang1 MPD:279
Data changelog	No updates/corrections. Initial release date: 07/2012.

QTL data set parameters:

Progenitor strains	BALB/cJ Apoe^-/- C57BL/6J Apoe^-/-
Cross direction notation	both
Cross type	F2 intercross
Population size	266 ♀ 0 ♂

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Zhang1	body weight	western diet	weight [g] Weight 27901	QTL population	f	18wks	N=266

Zhang1	colony observation	western diet	skin color Skin_color 27902	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	maximal carotid lesion [µm²] Carotid_lesion_max 27903	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	maximal lesion, ln transformed Carotid_lesion_LnMax 27904	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	maximal lesion, log transformed Carotid_lesion_L10Max 27905	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	maximal lesion, square root Carotid_lesion_MasSQ 27906	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average maximal 5 lesion [µm²/section] Carotid_lesion_Amax5 27907	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average maximal 5 lesion, ln transformed Carotid_lesion_LnAmax5 27908	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average maximal 5 lesion, log transformed Carotid_lesion_L10Am5 27909	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average maximal 5 lesion, square root Carotid_lesion_Am5sq 27910	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average lesion [µm²/section] Carotid_lesion_average 27911	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average lesion, ln transformed Carotid_lesion_LnAvg 27912	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average lesion, log transformed Carotid_lesion_L10Avg 27913	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average lesion, square root Carotid_lesion_AvgSq 27914	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	lesion double-checked [µm²/section] Carotid_lesion-recheck 27915	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	maximal lesion [µm²] Aortic_lesion_Max 27916	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average lesion [µm²/section] Aortic_lesion_Aveg 27917	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average maximal 5 lesion [µm²/section] Aortic_lesion_Amax5 27918	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average maximal 5 lesion, ln transformed Aortic_lesion_LnAmax5 27919	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	maximal lesion, square root Aortic_lesion_Max_Sqrt 27920	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average lesion, square root Aortic_lesion_Avg_sqrt 27921	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average maximal 5 lesion, square root Aortic_lesion_Amax5_sqrt 27922	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	maximal lesion, ln transformed Aortic_lesion_Max_LN 27923	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average lesion, ln transformed Aortic_lesion_Avg_LN 27924	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	maximal 10 lesion [µm²/section] Aortic_lesion_Max10 27926	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	average lesion, log10 transformed Aortic_lesion_Aveg_log10 27927	QTL population	f	18wks	N=266

Zhang1	lipid profile	(none)	plasma total cholesterol, chow [mg/dL] Total_Cholesterol 27928	QTL population	f	<6wks	N=266

Zhang1	lipid profile	(none)	plasma free cholesterol, chow [mg/dL] Free_Cholesterol 27929	QTL population	f	<6wks	N=266

Zhang1	lipid profile	(none)	plasma cholesterol ester, chow [mg/dL] Cholesterol_ester,_Chow 27930	QTL population	f	<6wks	N=266

Zhang1	lipid profile	(none)	HDL cholesterol, chow [mg/dL] HDL_Chow 27931	QTL population	f	<6wks	N=266

Zhang1	lipid profile	(none)	LDL cholesterol, chow [mg/dL] LDL_Chow 27932	QTL population	f	<6wks	N=266

Zhang1	lipid profile	(none)	plasma triglyceride, chow [mg/dL] Triglyceride_Chow 27933	QTL population	f	<6wks	N=266

Zhang1	lipid profile	(none)	ln(triglyceride), chow Ln_Triglyceride_Chow 27934	QTL population	f	<6wks	N=266

Zhang1	lipid profile	western diet	plasma total cholesterol, western diet [mg/dL] Total_Cholesterol_Western 27935	QTL population	f	18wks	N=266

Zhang1	lipid profile	western diet	plasma free cholesterol, western diet [mg/dL] Free_Cholesterol_Western 27936	QTL population	f	18wks	N=266

Zhang1	lipid profile	western diet	plasma cholesterol ester, western diet [mg/dL] Cholesterol_ester,_Western 27937	QTL population	f	18wks	N=266

Zhang1	lipid profile	western diet	HDL cholesterol, western diet [mg/dL] HDL_Western 27938	QTL population	f	18wks	N=266

Zhang1	lipid profile	western diet	LDL cholesterol, western diet [mg/dL] LDL_Western 27939	QTL population	f	18wks	N=266

Zhang1	lipid profile	western diet	ln(HDL), western diet Ln_HDL_Western 27940	QTL population	f	18wks	N=266

Zhang1	lipid profile	western diet	plasma triglyceride, western diet [mg/dL] Triglyceride_Western 27941	QTL population	f	18wks	N=266

Zhang1	metabolic panel	western diet	plasma glucose, western diet [mg/dL] Glucose_Western 27942	QTL population	f	18wks	N=266

Zhang1	metabolic panel	(none)	plasma glucose, chow [mg/dL] Glucose_Chow 27943	QTL population	f	<6wks	N=266

Zhang1	hormone quantification	western diet	plasma insulin [ng/mL] Insulin_mean 27944	QTL population	f	18wks	N=266

Zhang1	hormone quantification	western diet	ln(insulin) Ln_insulin 27945	QTL population	f	18wks	N=266

Zhang1	histopathology	western diet	total aortic lesion size [µm²] Aortic_lesion_Sum 27946	QTL population	f	18wks	N=266

To see more rows use the paging control at top.

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Ath41 Ath42 Bglu12 Bglu13 Bglu14 Bglu15 Bglu18

Project / data set: Zhang1 a.k.a. Zhang_2012
Excel file: Data_Description_BL6xBALB_Zhang2012.xlsx
CSV file: Zhang2012_BL6xBALB_B37_Data.csv
Readme / text file: readme_Zhang2012.txt
QC plots, figures, etc.: QCReport_Zhang2012.pdf