MPD: Data set: Zhang1

Zhang1: Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice (2012)

Zhang Z, Rowlan JS, Wang Q, Shi W. Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2012 Apr 1;5(2):190-20Epub 2012 Jan 31. PubMed 22294616 FullText

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Participants	Z Zhang Gary A Churchill The Jackson Laboratory Bar Harbor, ME With: Rowlan JS, Wang Q, Shi W
Contact	Gary A Churchill gary.churchill@jax.org
Affiliation	Churchill Group QTL Archive
Acknowledgements	Grant: The research was supported by grants from the National Institutes of Health (AR43618, RR08911-5,CA34196), the US Army (DAMA17-94-J-4016), and the S.D. Bechtel Foundation.
Project type	QTL Archive data set
MPD identifiers	Zhang1 MPD:279
Data changelog	No updates/corrections. Initial release date: 07/2012.

Female F2 mice (n 266) were generated from an intercross between B6.Apoe -/- and BALB.Apoe -/- mice and fed a Western diet for 12 weeks. Atherosclerotic lesions in the aortic root, fasting plasma glucose, and body weight were measured. 130 microsatellite markers across the entire genome were genotyped. Four significant QTLs, Ath1 on chromosome (Chr) 1, Ath41 on Chr2, Ath42 on Chr5, and Ath29 on Chr9, and 1 suggestive QTL on Chr4, were identified for atherosclerotic lesion size. Four significant QTLs, Bglu3 and Bglu12 on Chr1, Bglu13 on Chr5, Bglu15 on Chr12, and 2 suggestive QTLs on Chr9 and Chr15 were identified for fasting glucose levels on the chow diet. Two significant QTLs, Bglu3 and Bglu13, and 1 suggestive locus on Chr8 were identified for fasting glucose on the Western diet. One significant locus on Chr1 and 2 suggestive loci on Chr9 and Chr19 were identified for body weight. Ath1 and Ath42 coincided with Bglu3 and Bglu13, respectively, in the confidence interval.

QTL data set parameters:

Progenitor strains	BALB/cJ Apoe^-/- C57BL/6J Apoe^-/-
Cross direction notation	both
Cross type	F2 intercross
Population size	266 ♀ 0 ♂

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	MPD ID	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	Sex	Age	Sample Size (Avg)
Zhang1	27901	body weight	western diet	weight [g] Weight	QTL population	f	18wks	N=266

Zhang1	27902	colony observation	western diet	skin color Skin_color	QTL population	f	18wks	N=266

Zhang1	27903	histopathology	western diet	maximal carotid lesion [µm²] Carotid_lesion_max	QTL population	f	18wks	N=266

Zhang1	27904	histopathology	western diet	maximal lesion, ln transformed Carotid_lesion_LnMax	QTL population	f	18wks	N=266

Zhang1	27905	histopathology	western diet	maximal lesion, log transformed Carotid_lesion_L10Max	QTL population	f	18wks	N=266

Zhang1	27906	histopathology	western diet	maximal lesion, square root Carotid_lesion_MasSQ	QTL population	f	18wks	N=266

Zhang1	27907	histopathology	western diet	average maximal 5 lesion [µm²/section] Carotid_lesion_Amax5	QTL population	f	18wks	N=266

Zhang1	27908	histopathology	western diet	average maximal 5 lesion, ln transformed Carotid_lesion_LnAmax5	QTL population	f	18wks	N=266

Zhang1	27909	histopathology	western diet	average maximal 5 lesion, log transformed Carotid_lesion_L10Am5	QTL population	f	18wks	N=266

Zhang1	27910	histopathology	western diet	average maximal 5 lesion, square root Carotid_lesion_Am5sq	QTL population	f	18wks	N=266

Zhang1	27911	histopathology	western diet	average lesion [µm²/section] Carotid_lesion_average	QTL population	f	18wks	N=266

Zhang1	27912	histopathology	western diet	average lesion, ln transformed Carotid_lesion_LnAvg	QTL population	f	18wks	N=266

Zhang1	27913	histopathology	western diet	average lesion, log transformed Carotid_lesion_L10Avg	QTL population	f	18wks	N=266

Zhang1	27914	histopathology	western diet	average lesion, square root Carotid_lesion_AvgSq	QTL population	f	18wks	N=266

Zhang1	27915	histopathology	western diet	lesion double-checked [µm²/section] Carotid_lesion-recheck	QTL population	f	18wks	N=266

Zhang1	27916	histopathology	western diet	maximal lesion [µm²] Aortic_lesion_Max	QTL population	f	18wks	N=266

Zhang1	27917	histopathology	western diet	average lesion [µm²/section] Aortic_lesion_Aveg	QTL population	f	18wks	N=266

Zhang1	27918	histopathology	western diet	average maximal 5 lesion [µm²/section] Aortic_lesion_Amax5	QTL population	f	18wks	N=266

Zhang1	27919	histopathology	western diet	average maximal 5 lesion, ln transformed Aortic_lesion_LnAmax5	QTL population	f	18wks	N=266

Zhang1	27920	histopathology	western diet	maximal lesion, square root Aortic_lesion_Max_Sqrt	QTL population	f	18wks	N=266

Zhang1	27921	histopathology	western diet	average lesion, square root Aortic_lesion_Avg_sqrt	QTL population	f	18wks	N=266

Zhang1	27922	histopathology	western diet	average maximal 5 lesion, square root Aortic_lesion_Amax5_sqrt	QTL population	f	18wks	N=266

Zhang1	27923	histopathology	western diet	maximal lesion, ln transformed Aortic_lesion_Max_LN	QTL population	f	18wks	N=266

Zhang1	27924	histopathology	western diet	average lesion, ln transformed Aortic_lesion_Avg_LN	QTL population	f	18wks	N=266

Zhang1	27926	histopathology	western diet	maximal 10 lesion [µm²/section] Aortic_lesion_Max10	QTL population	f	18wks	N=266

Zhang1	27927	histopathology	western diet	average lesion, log10 transformed Aortic_lesion_Aveg_log10	QTL population	f	18wks	N=266

Zhang1	27928	lipid profile	(none)	plasma total cholesterol, chow [mg/dL] Total_Cholesterol	QTL population	f	<6wks	N=266

Zhang1	27929	lipid profile	(none)	plasma free cholesterol, chow [mg/dL] Free_Cholesterol	QTL population	f	<6wks	N=266

Zhang1	27930	lipid profile	(none)	plasma cholesterol ester, chow [mg/dL] Cholesterol_ester,_Chow	QTL population	f	<6wks	N=266

Zhang1	27931	lipid profile	(none)	HDL cholesterol, chow [mg/dL] HDL_Chow	QTL population	f	<6wks	N=266

Zhang1	27932	lipid profile	(none)	LDL cholesterol, chow [mg/dL] LDL_Chow	QTL population	f	<6wks	N=266

Zhang1	27933	lipid profile	(none)	plasma triglyceride, chow [mg/dL] Triglyceride_Chow	QTL population	f	<6wks	N=266

Zhang1	27934	lipid profile	(none)	ln( triglyceride ), chow Ln_Triglyceride_Chow	QTL population	f	<6wks	N=266

Zhang1	27935	lipid profile	western diet	plasma total cholesterol, western diet [mg/dL] Total_Cholesterol_Western	QTL population	f	18wks	N=266

Zhang1	27936	lipid profile	western diet	plasma free cholesterol, western diet [mg/dL] Free_Cholesterol_Western	QTL population	f	18wks	N=266

Zhang1	27937	lipid profile	western diet	plasma cholesterol ester, western diet [mg/dL] Cholesterol_ester,_Western	QTL population	f	18wks	N=266

Zhang1	27938	lipid profile	western diet	HDL cholesterol, western diet [mg/dL] HDL_Western	QTL population	f	18wks	N=266

Zhang1	27939	lipid profile	western diet	LDL cholesterol, western diet [mg/dL] LDL_Western	QTL population	f	18wks	N=266

Zhang1	27940	lipid profile	western diet	ln(HDL ), western diet Ln_HDL_Western	QTL population	f	18wks	N=266

Zhang1	27941	lipid profile	western diet	plasma triglyceride, western diet [mg/dL] Triglyceride_Western	QTL population	f	18wks	N=266

Zhang1	27942	metabolic panel	western diet	plasma glucose, western diet [mg/dL] Glucose_Western	QTL population	f	18wks	N=266

Zhang1	27943	metabolic panel	(none)	plasma glucose, chow [mg/dL] Glucose_Chow	QTL population	f	<6wks	N=266

Zhang1	27944	hormone quantification	western diet	plasma insulin [ng/mL] Insulin_mean	QTL population	f	18wks	N=266

Zhang1	27945	hormone quantification	western diet	ln( insulin ) Ln_insulin	QTL population	f	18wks	N=266

Zhang1	27946	histopathology	western diet	total aortic lesion size [µm²] Aortic_lesion_Sum	QTL population	f	18wks	N=266

To see more rows use the paging control at top.

Associated genomic features

MGI-curated genes / genomic features that have been associated with this data set:
Ath41 Ath42 Bglu12 Bglu13 Bglu14 Bglu15

Project / data set: Zhang1 a.k.a. Zhang_2012
Excel file: Data_Description_BL6xBALB_Zhang2012.xlsx
CSV file: Zhang2012_BL6xBALB_B37_Data.csv
Readme / text file: readme_Zhang2012.txt
QC plots, figures, etc.: QCReport_Zhang2012.pdf