Female F2 mice (n 266) were generated from an intercross between B6.Apoe -/- and
BALB.Apoe -/- mice and fed a Western diet for 12 weeks. Atherosclerotic lesions in the aortic root, fasting plasma
glucose, and body weight were measured. 130 microsatellite markers across the entire genome were genotyped.
Four significant QTLs, Ath1 on chromosome (Chr) 1, Ath41 on Chr2, Ath42 on Chr5, and Ath29 on Chr9, and 1
suggestive QTL on Chr4, were identified for atherosclerotic lesion size. Four significant QTLs, Bglu3 and Bglu12
on Chr1, Bglu13 on Chr5, Bglu15 on Chr12, and 2 suggestive QTLs on Chr9 and Chr15 were identified for fasting
glucose levels on the chow diet. Two significant QTLs, Bglu3 and Bglu13, and 1 suggestive locus on Chr8 were
identified for fasting glucose on the Western diet. One significant locus on Chr1 and 2 suggestive loci on Chr9 and
Chr19 were identified for body weight. Ath1 and Ath42 coincided with Bglu3 and Bglu13, respectively, in the confidence interval.