Zhang Z, Rowlan JS, Wang Q, Shi W. Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.
Circ Cardiovasc Genet. 2012 Apr 1;5(2):190-20Epub 2012 Jan 31.
Participants |
Z Zhang Gary A Churchill The Jackson Laboratory Bar Harbor, ME With: Rowlan JS, Wang Q, Shi W |
Contact | Gary A Churchill gary.churchill@jax.org |
Affiliation | Churchill Group QTL Archive |
Acknowledgements | Grant: The research was supported by grants from the National Institutes of Health (AR43618, RR08911-5,CA34196), the US Army (DAMA17-94-J-4016), and the S.D. Bechtel Foundation. |
QTL Archive data set | |
MPD identifiers | Zhang1 MPD:279 |
No updates/corrections. Initial release date: 07/2012. |
Progenitor strains | BALB/cJ Apoe^{-/-} C57BL/6J Apoe^{-/-} |
Cross direction notation | both |
Cross type | F2 intercross |
Population size | 266 ♀ 0 ♂ |
Data set | MPD ID | Procedure / Protocol | Drug or Challenge | Phenotype Measure | Panel | No. of Strains | Sex | Age | Sample Size (Avg) | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
27901 | body weight | western diet | weight [g] Weight | QTL population | f | N=266 | |||||||
27902 | colony observation | western diet | skin color Skin_color | QTL population | f | N=266 | |||||||
27903 | histopathology | western diet | maximal carotid lesion [µm^{2}] Carotid_lesion_max | QTL population | f | N=266 | |||||||
27904 | histopathology | western diet | maximal lesion, ln transformed Carotid_lesion_LnMax | QTL population | f | N=266 | |||||||
27905 | histopathology | western diet | maximal lesion, log transformed Carotid_lesion_L10Max | QTL population | f | N=266 | |||||||
27906 | histopathology | western diet | maximal lesion, square root Carotid_lesion_MasSQ | QTL population | f | N=266 | |||||||
27907 | histopathology | western diet | average maximal 5 lesion [µm^{2}/section] Carotid_lesion_Amax5 | QTL population | f | N=266 | |||||||
27908 | histopathology | western diet | average maximal 5 lesion, ln transformed Carotid_lesion_LnAmax5 | QTL population | f | N=266 | |||||||
27909 | histopathology | western diet | average maximal 5 lesion, log transformed Carotid_lesion_L10Am5 | QTL population | f | N=266 | |||||||
27910 | histopathology | western diet | average maximal 5 lesion, square root Carotid_lesion_Am5sq | QTL population | f | N=266 | |||||||
27911 | histopathology | western diet | average lesion [µm^{2}/section] Carotid_lesion_average | QTL population | f | N=266 | |||||||
27912 | histopathology | western diet | average lesion, ln transformed Carotid_lesion_LnAvg | QTL population | f | N=266 | |||||||
27913 | histopathology | western diet | average lesion, log transformed Carotid_lesion_L10Avg | QTL population | f | N=266 | |||||||
27914 | histopathology | western diet | average lesion, square root Carotid_lesion_AvgSq | QTL population | f | N=266 | |||||||
27915 | histopathology | western diet | lesion double-checked [µm^{2}/section] Carotid_lesion-recheck | QTL population | f | N=266 | |||||||
27916 | histopathology | western diet | maximal lesion [µm^{2}] Aortic_lesion_Max | QTL population | f | N=266 | |||||||
27917 | histopathology | western diet | average lesion [µm^{2}/section] Aortic_lesion_Aveg | QTL population | f | N=266 | |||||||
27918 | histopathology | western diet | average maximal 5 lesion [µm^{2}/section] Aortic_lesion_Amax5 | QTL population | f | N=266 | |||||||
27919 | histopathology | western diet | average maximal 5 lesion, ln transformed Aortic_lesion_LnAmax5 | QTL population | f | N=266 | |||||||
27920 | histopathology | western diet | maximal lesion, square root Aortic_lesion_Max_Sqrt | QTL population | f | N=266 | |||||||
27921 | histopathology | western diet | average lesion, square root Aortic_lesion_Avg_sqrt | QTL population | f | N=266 | |||||||
27922 | histopathology | western diet | average maximal 5 lesion, square root Aortic_lesion_Amax5_sqrt | QTL population | f | N=266 | |||||||
27923 | histopathology | western diet | maximal lesion, ln transformed Aortic_lesion_Max_LN | QTL population | f | N=266 | |||||||
27924 | histopathology | western diet | average lesion, ln transformed Aortic_lesion_Avg_LN | QTL population | f | N=266 | |||||||
27926 | histopathology | western diet | maximal 10 lesion [µm^{2}/section] Aortic_lesion_Max10 | QTL population | f | N=266 | |||||||
27927 | histopathology | western diet | average lesion, log10 transformed Aortic_lesion_Aveg_log10 | QTL population | f | N=266 | |||||||
27928 | lipid profile | (none) | plasma total cholesterol, chow [mg/dL] Total_Cholesterol | QTL population | f | N=266 | |||||||
27929 | lipid profile | (none) | plasma free cholesterol, chow [mg/dL] Free_Cholesterol | QTL population | f | N=266 | |||||||
27930 | lipid profile | (none) | plasma cholesterol ester, chow [mg/dL] Cholesterol_ester,_Chow | QTL population | f | N=266 | |||||||
27931 | lipid profile | (none) | HDL cholesterol, chow [mg/dL] HDL_Chow | QTL population | f | N=266 | |||||||
27932 | lipid profile | (none) | LDL cholesterol, chow [mg/dL] LDL_Chow | QTL population | f | N=266 | |||||||
27933 | lipid profile | (none) | plasma triglyceride, chow [mg/dL] Triglyceride_Chow | QTL population | f | N=266 | |||||||
27934 | lipid profile | (none) | ln(triglyceride), chow Ln_Triglyceride_Chow | QTL population | f | N=266 | |||||||
27935 | lipid profile | western diet | plasma total cholesterol, western diet [mg/dL] Total_Cholesterol_Western | QTL population | f | N=266 | |||||||
27936 | lipid profile | western diet | plasma free cholesterol, western diet [mg/dL] Free_Cholesterol_Western | QTL population | f | N=266 | |||||||
27937 | lipid profile | western diet | plasma cholesterol ester, western diet [mg/dL] Cholesterol_ester,_Western | QTL population | f | N=266 | |||||||
27938 | lipid profile | western diet | HDL cholesterol, western diet [mg/dL] HDL_Western | QTL population | f | N=266 | |||||||
27939 | lipid profile | western diet | LDL cholesterol, western diet [mg/dL] LDL_Western | QTL population | f | N=266 | |||||||
27940 | lipid profile | western diet | ln(HDL), western diet Ln_HDL_Western | QTL population | f | N=266 | |||||||
27941 | lipid profile | western diet | plasma triglyceride, western diet [mg/dL] Triglyceride_Western | QTL population | f | N=266 | |||||||
27942 | metabolic panel | western diet | plasma glucose, western diet [mg/dL] Glucose_Western | QTL population | f | N=266 | |||||||
27943 | metabolic panel | (none) | plasma glucose, chow [mg/dL] Glucose_Chow | QTL population | f | N=266 | |||||||
27944 | hormone quantification | western diet | plasma insulin [ng/mL] Insulin_mean | QTL population | f | N=266 | |||||||
27945 | hormone quantification | western diet | ln(insulin) Ln_insulin | QTL population | f | N=266 | |||||||
27946 | histopathology | western diet | total aortic lesion size [µm^{2}] Aortic_lesion_Sum | QTL population | f | N=266 | |||||||