Zhang Z, Rowlan JS, Wang Q, Shi W. Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.
Circ Cardiovasc Genet. 2012 Apr 1;5(2):190-20Epub 2012 Jan 31.
Investigators |
Z Zhang Gary A Churchill The Jackson Laboratory, Bar Harbor, ME |
Participants | Rowlan JS, Wang Q, Shi W |
Contact | Gary A Churchill gary.churchill@jax.org |
Affiliated Center | QTL Archive |
Acknowledgements | Grant: The research was supported by grants from the National Institutes of Health (AR43618, RR08911-5,CA34196), the US Army (DAMA17-94-J-4016), and the S.D. Bechtel Foundation. |
QTL Archive data set | |
MPD identifiers | Zhang1 MPD:279 |
No updates/corrections. Initial release date: 07/2012. |
Progenitor strains | BALB/cJ Apoe-/- C57BL/6J Apoe-/- |
Cross direction notation | both |
Cross type | F2 intercross |
Population size | 266 ♀ 0 ♂ |
Data set | Procedure / Protocol | Treatment | Phenotype Measure / Variable (click to view) | Panel | No. of Strains | Sex | Age | Sample Size (Avg) | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
body weight | western diet | weight [g] Weight 27901 | QTL population | f | N=266 | |||||||
colony observation | western diet | skin color Skin_color 27902 | QTL population | f | N=266 | |||||||
histopathology | western diet | maximal carotid lesion [µm2] Carotid_lesion_max 27903 | QTL population | f | N=266 | |||||||
histopathology | western diet | maximal lesion, ln transformed Carotid_lesion_LnMax 27904 | QTL population | f | N=266 | |||||||
histopathology | western diet | maximal lesion, log transformed Carotid_lesion_L10Max 27905 | QTL population | f | N=266 | |||||||
histopathology | western diet | maximal lesion, square root Carotid_lesion_MasSQ 27906 | QTL population | f | N=266 | |||||||
histopathology | western diet | average maximal 5 lesion [µm2/section] Carotid_lesion_Amax5 27907 | QTL population | f | N=266 | |||||||
histopathology | western diet | average maximal 5 lesion, ln transformed Carotid_lesion_LnAmax5 27908 | QTL population | f | N=266 | |||||||
histopathology | western diet | average maximal 5 lesion, log transformed Carotid_lesion_L10Am5 27909 | QTL population | f | N=266 | |||||||
histopathology | western diet | average maximal 5 lesion, square root Carotid_lesion_Am5sq 27910 | QTL population | f | N=266 | |||||||
histopathology | western diet | average lesion [µm2/section] Carotid_lesion_average 27911 | QTL population | f | N=266 | |||||||
histopathology | western diet | average lesion, ln transformed Carotid_lesion_LnAvg 27912 | QTL population | f | N=266 | |||||||
histopathology | western diet | average lesion, log transformed Carotid_lesion_L10Avg 27913 | QTL population | f | N=266 | |||||||
histopathology | western diet | average lesion, square root Carotid_lesion_AvgSq 27914 | QTL population | f | N=266 | |||||||
histopathology | western diet | lesion double-checked [µm2/section] Carotid_lesion-recheck 27915 | QTL population | f | N=266 | |||||||
histopathology | western diet | maximal lesion [µm2] Aortic_lesion_Max 27916 | QTL population | f | N=266 | |||||||
histopathology | western diet | average lesion [µm2/section] Aortic_lesion_Aveg 27917 | QTL population | f | N=266 | |||||||
histopathology | western diet | average maximal 5 lesion [µm2/section] Aortic_lesion_Amax5 27918 | QTL population | f | N=266 | |||||||
histopathology | western diet | average maximal 5 lesion, ln transformed Aortic_lesion_LnAmax5 27919 | QTL population | f | N=266 | |||||||
histopathology | western diet | maximal lesion, square root Aortic_lesion_Max_Sqrt 27920 | QTL population | f | N=266 | |||||||
histopathology | western diet | average lesion, square root Aortic_lesion_Avg_sqrt 27921 | QTL population | f | N=266 | |||||||
histopathology | western diet | average maximal 5 lesion, square root Aortic_lesion_Amax5_sqrt 27922 | QTL population | f | N=266 | |||||||
histopathology | western diet | maximal lesion, ln transformed Aortic_lesion_Max_LN 27923 | QTL population | f | N=266 | |||||||
histopathology | western diet | average lesion, ln transformed Aortic_lesion_Avg_LN 27924 | QTL population | f | N=266 | |||||||
histopathology | western diet | maximal 10 lesion [µm2/section] Aortic_lesion_Max10 27926 | QTL population | f | N=266 | |||||||
histopathology | western diet | average lesion, log10 transformed Aortic_lesion_Aveg_log10 27927 | QTL population | f | N=266 | |||||||
lipid profile | (none) | plasma total cholesterol, chow [mg/dL] Total_Cholesterol 27928 | QTL population | f | N=266 | |||||||
lipid profile | (none) | plasma free cholesterol, chow [mg/dL] Free_Cholesterol 27929 | QTL population | f | N=266 | |||||||
lipid profile | (none) | plasma cholesterol ester, chow [mg/dL] Cholesterol_ester,_Chow 27930 | QTL population | f | N=266 | |||||||
lipid profile | (none) | HDL cholesterol, chow [mg/dL] HDL_Chow 27931 | QTL population | f | N=266 | |||||||
lipid profile | (none) | LDL cholesterol, chow [mg/dL] LDL_Chow 27932 | QTL population | f | N=266 | |||||||
lipid profile | (none) | plasma triglyceride, chow [mg/dL] Triglyceride_Chow 27933 | QTL population | f | N=266 | |||||||
lipid profile | (none) | ln(triglyceride), chow Ln_Triglyceride_Chow 27934 | QTL population | f | N=266 | |||||||
lipid profile | western diet | plasma total cholesterol, western diet [mg/dL] Total_Cholesterol_Western 27935 | QTL population | f | N=266 | |||||||
lipid profile | western diet | plasma free cholesterol, western diet [mg/dL] Free_Cholesterol_Western 27936 | QTL population | f | N=266 | |||||||
lipid profile | western diet | plasma cholesterol ester, western diet [mg/dL] Cholesterol_ester,_Western 27937 | QTL population | f | N=266 | |||||||
lipid profile | western diet | HDL cholesterol, western diet [mg/dL] HDL_Western 27938 | QTL population | f | N=266 | |||||||
lipid profile | western diet | LDL cholesterol, western diet [mg/dL] LDL_Western 27939 | QTL population | f | N=266 | |||||||
lipid profile | western diet | ln(HDL), western diet Ln_HDL_Western 27940 | QTL population | f | N=266 | |||||||
lipid profile | western diet | plasma triglyceride, western diet [mg/dL] Triglyceride_Western 27941 | QTL population | f | N=266 | |||||||
metabolic panel | western diet | plasma glucose, western diet [mg/dL] Glucose_Western 27942 | QTL population | f | N=266 | |||||||
metabolic panel | (none) | plasma glucose, chow [mg/dL] Glucose_Chow 27943 | QTL population | f | N=266 | |||||||
hormone quantification | western diet | plasma insulin [ng/mL] Insulin_mean 27944 | QTL population | f | N=266 | |||||||
hormone quantification | western diet | ln(insulin) Ln_insulin 27945 | QTL population | f | N=266 | |||||||
histopathology | western diet | total aortic lesion size [µm2] Aortic_lesion_Sum 27946 | QTL population | f | N=266 | |||||||