MPD: Data set: Stylianou1

Stylianou1: Weight and distribution of fat pads in F2 progeny of SM/J x NZB/BlNJ (2006)

Stylianou IM, Korstanje R, Li R, Sheehan S, Paigen B, Churchill GA. Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36. Epub 2006 Jan 13. PubMed 16416088

An intercross of 513 F(2) progeny between the SM/J x NZB/BlNJ inbred mouse strains was generated to identify QTLs that are involved in the weight of four fat pads: mesenteric, inguinal, gonadal, and retroperitoneal. Mice were administered a high fat (15%) diet from 8 to 24 wks of age (16 wks on high fat diet). For a detailed protocol see Stylianou et al 2006.

Note on studied population: SM/J x NZB/BlNJ F2 progeny

Procedures conducted:

• study archive

Body size, weight, fat pad weights after high-fat diet.

Stylianou1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Stylianou1 measures:

MA:0000009 adipose tissue
MA:0000472 abdominal fat pad
MA:0002481 fat pad
MA:0002547 gonadal fat pad
MA:0002548 inguinal fat pad
MA:0002549 retroperitoneal fat pad
MP:0001256 abnormal body length
MP:0001259 abnormal body weight
MP:0005335 abnormal gonadal fat pad morphology
MP:0005336 abnormal inguinal fat pad morphology
MP:0005337 abnormal retroperitoneal fat pad morphology
MP:0008903 abnormal mesenteric fat pad morphology
MP:0020130 abnormal total fat pad weight
VT:0001256 body length
VT:0001259 body mass
VT:0010423 gonadal fat pad mass
VT:0010424 inguinal fat pad mass
VT:0010427 mesenteric fat pad mass
VT:0010430 retroperitoneal fat pad mass
VT:0015008 total fat pad mass

Investigators	Ioannis M Stylianou Xenon Pharmaceuticals, Burnaby, British Columbia CANADA Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Korstanje R, Li R, Sheehan S, Paigen B
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Funding provided by NIH HL66611, GM070683, CA34196.
Project type	QTL Archive data set
MPD identifiers	Stylianou1 MPD:184
Data changelog	No updates/corrections. Initial release date: 01/2008.

QTL data set parameters:

Progenitor strains	NZB/BlNJ SM/J
Cross type	F2 intercross
Population size	259 ♀ 254 ♂
Age	24wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Stylianou1	body weight	high-fat diet	body weight [g] bw 18401	QTL population	both	24wks	N=256

Stylianou1	body weight	high-fat diet	body weight, log transformed [log(g)] log_bw 18402	QTL population	both	24wks	N=256

Stylianou1	body size and weight	high-fat diet	body length [cm] length 18403	QTL population	both	24wks	N=256

Stylianou1	body size and weight	high-fat diet	body length, log transformed [log(cm)] log_length 18404	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	total weight of all fat pads [g] fat_pads 18405	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	total weight of all fat pads, log transformed [log(g)] log_fat_pads 18406	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	inguinal fat pad weight (left) [g] inguinal 18407	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	inguinal fat pad weight (total) [g] inguinal_tot 18408	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	inguinal fat pads, normalized to total fat pads, log transformed [log(ratio)] log_inguinal 18409	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	gonadal fat pad weight (left) [g] gonadal 18410	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	gonadal fat pad weight (total) [g] gonadal_tot 18411	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	gonadal fat pads, normalized to total fat pads, log transformed [log(ratio)] log_gonadal 18412	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	retroperitoneal fat pad weight (left) [g] peritoneal 18413	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	retroperitoneal fat pad weight (total) [g] peritoneal_tot 18414	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	retroperitoneal fat pads, normalized to total fat pads, log transformed [log(ratio)] log_peritoneal 18415	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	mesenteric fat pad weight [g] mesenteric 18416	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	mesenteric fat pad, normalized to total fat pads, log transformed [log(ratio)] log_mesenteric 18417	QTL population	both	24wks	N=256

Stylianou1	fat pad weights	high-fat diet	adiposity index (total fat pad weight normalized to lean body weight) [%] AI 18418	QTL population	both	24wks	N=256

To see more rows use the paging control at top.

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Adip10 Adip11 Adip12 Adip13 Adip14 Adip15 Adip16 Adip17 Adip18 Bwtq10 Bwtq11 Bwtq12 Bwtq8 Bwtq9 Obq20 Obq21 Obq22 Obwq1 Obwq2 Obwq3 Obwq4 Obwq5

Project / data set: Stylianou1 a.k.a. Stylianou_2006
Excel file: Data_Description_B6xA_Stylianou2006b.xlsx
Excel file: Data_Description_CSS3_Stylianou2006c.xlsx
Excel file: Data_Description_CSS8_Stylianou2006d.xlsx
Excel file: ._Data_Description_CSS11_Stylianou2006e.xlsx
Excel file: Data_Description_CSS11_Stylianou2006e.xlsx
CSV file: Stylianou2006b_B6xA_B37_Data.csv
CSV file: Stylianou2006c_CSS3_B37_Data.csv
CSV file: Stylianou2006d_CSS8_B37_Data.csv
CSV file: ._Stylianou2006e_CSS11_B37_Data.csv
CSV file: Stylianou2006e_CSS11_B37_Data.csv
Readme / text file: readme_Stylianou2006b.txt
Readme / text file: readme_Stylianou2006c.txt
Readme / text file: readme_Stylianou2006d.txt
Readme / text file: ._readme_Stylianou2006e.txt
Readme / text file: readme_Stylianou2006e.txt