Stylianou2: HDL in B6.A consomic and F2 mouse crosses (2006)

Stylianou IM, Tsaih SW, DiPetrillo K, Ishimori N, Li R, Paigen B, Churchill G. Complex genetic architecture revealed by analysis of high-density lipoprotein cholesterol in chromosome substitution strains and F2 crosses. Genetics. 2006 Oct;174(2):999-1007. Epub 2006 Sep 1.   PubMed 16951076  


     
Stylianou2 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants Ioannis M Stylianou       Xenon Pharmaceuticals Burnaby, British Columbia CANADA
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Tsaih SW, DiPetrillo K, Ishimori N, Li R, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by The American Heart Association grant 0525816T and the National Institutes of Health grants HL77796 (to B.J.P) and GM070683 (to G.C).
Project type QTL Archive data set
MPD identifiersStylianou2     MPD:185
Data changelog No updates/corrections.       Initial release date: 02/2011.
This project is to examine the genetic architecture underlying plasma high-density lipoprotein cholesterol (HDL) levels in the C57BL/6J (B) and A/J (A) mouse strains. We compared the QTL results of HDL in a classical F2 intercross with three chromosome (chr3, 8 and 11) substitution strains (CSS) intercrosses. For detailed protocols see Stylianou et al Genetics (2006; 174: 999-1007).


QTL data set parameters:
Dataset 1: B6 x A/J       Stylianou2
Progenitor strains A/J     C57BL/6J    
Cross direction notation(B6xA) F1 x (B6xA) F1
Cross typeF2 intercross
Population size 271 ♀     343 ♂

Dataset 2: B6 x CSS-3       Stylianou2c
Progenitor strains B6.A-Chr3     C57BL/6J    
Cross direction notation(B6xCSS-3) F1 x (B6xCSS-3) F1
Cross typeF2 intercross
Population size 74 ♀     72 ♂

Dataset 3: B6 x CSS-8       Stylianou2d
Progenitor strains B6.A-Chr8     C57BL/6J    
Cross direction notation(B6xCSS-8) F1 x (B6xCSS-8) F1
Cross typeF2 intercross
Population size 78 ♀     72 ♂

Dataset 4: B6 x CSS-11       Stylianou2e
Progenitor strains B6.A-Chr11     C57BL/6J    
Cross direction notation(B6xCSS-11) F1 x (B6xCSS-11) F1
Cross typeF2 intercross
Population size 105 ♀     95 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Stylianou2 18501 body weight (none) body weight   [g]  BW QTL population both 8-10wks N=307
Stylianou2 18502 lipid profile (none) triglycerides   [mg/dL]  TG QTL population both 8-10wks N=307
Stylianou2 18503 lipid profile (none) HDL cholesterol   [mg/dL]  HDL QTL population both 8-10wks N=307
Stylianou2 18504 lipid profile (none) cholesterol   [mg/dL]  CHOL QTL population both 8-10wks N=307
Stylianou2 18505 lipid profile (none) non-HDL cholesterol   [mg/dL]  nonHDL QTL population both N=307

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Hdlq40   Hdlq41   Hdlq42   Hdlq43   Hdlq44   Hdlq45   Hdlq46   Hdlq47   Hdlq48   Hdlq49   Hdlq50   Hdlq51  


Dataset 1: B6 x A/J     Stylianou2     a.k.a. Stylianou_2006b
Excel file:   Data_Description_B6xA_Stylianou2006b.xlsx
CSV file:   Stylianou2006b_B6xA_B37_Data.csv
Readme / text file:   readme_Stylianou2006b.txt

Dataset 2: B6 x CSS-3     Stylianou2c     a.k.a. Stylianou_2006c
Excel file:   Data_Description_CSS3_Stylianou2006c.xlsx
CSV file:   Stylianou2006c_CSS3_B37_Data.csv
Readme / text file:   readme_Stylianou2006c.txt

Dataset 3: B6 x CSS-8     Stylianou2d     a.k.a. Stylianou_2006d
Excel file:   Data_Description_CSS8_Stylianou2006d.xlsx
CSV file:   Stylianou2006d_CSS8_B37_Data.csv
Readme / text file:   readme_Stylianou2006d.txt

Dataset 4: B6 x CSS-11     Stylianou2e     a.k.a. Stylianou_2006e
Excel file:   Data_Description_CSS11_Stylianou2006e.xlsx
CSV file:   Stylianou2006e_CSS11_B37_Data.csv
Readme / text file:   readme_Stylianou2006e.txt