Li1: Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice (2008)

Li Q, Li Y, Zhang Z, Gilbert TR, Matsumoto AH, Dobrin SE, Shi W. Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Stroke. 2008 Jan;39(1):166-73. Epub 2007 Nov 29.   PubMed 18048852     FullText


       
Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerotic lesion formation in the carotid arteries on the apolipoprotein E–deficient background when fed Western diet. QTL analysis was performed on an intercross between B6.apoE-/- and C3H.apoE-/- mice to determine genetic factors contributing to variation in the phenotype. The authors found carotid atherosclerosis and plasma lipids are controlled by separate genetic factors in the B6 and C3H mouse model. For detailed protocols see Li et al 2008.

Note on studied population: C57BL/6 x C3H intercross

Procedures conducted:
• study archive  Lipids, atherosclerosis lesion histopathology. High-fat, western-style diet.

Li1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators Q Li
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Li Y, Zhang Z, Gilbert TR, Matsumoto AH, Dobrin SE, Shi W
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThis study was supported by the National Institutes of Health grant HL75433 and by the NHLBI Mammalian Genotyping Service (contract HV48141) for the genotyping.
Project type QTL Archive data set
MPD identifiersLi1     MPD:210
Data changelog No updates/corrections.       Initial release date: 08/2010.
QTL data set parameters:
Progenitor strains B6.apoE-/-     C3H.apoE-/-    
Cross direction notation(B6xC3H) F1 x (B6xC3H) F1
Cross typeF2 intercross
Population size 241 ♀     0 ♂
Age12wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Li1 lipid profile western diet total cholesterol level   [mm/dL]  Total_cholesterol   21001 QTL population f 12wks N=241
Li1 lipid profile western diet high-density lipoprotein cholesterol   [mm/dL]  HDL   21002 QTL population f 12wks N=241
Li1 lipid profile western diet HDL, log-transformed   [log(mm/dL)]  LogHDL   21003 QTL population f 12wks N=241
Li1 lipid profile western diet low-density lipoprotein / very-low-density lipoprotein   [mm/dL]  LDL/VLDL   21004 QTL population f 12wks N=241
Li1 lipid profile western diet LDL/VLDL, log transformed   [log(mm/dL)]  LogLDL/VLDL   21005 QTL population f 12wks N=241
Li1 lipid profile western diet triglyceride levels   [mm/dL]  Triglyceride   21006 QTL population f 12wks N=241
Li1 body weight western diet body weight of mouse  Body_weight   21007 QTL population f 12wks N=241
Li1 histopathology western diet carotid atherosclerotic lesion area size (the average of 5 largest sections)   [µm2/section]  Carotid_lesion-LGMax   21008 QTL population f 12wks N=241

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Cath1   Hdl4   Hdl5   Hdlq15   Hdlq86   Hdlq91   Hdlq94   Lprq4   Nhdlq11   Nhdlq12   Pnhdlc6   Trigq3   Trigq4  


Project / data set:   Li1     a.k.a. Li_2008
Excel file:   Data_Description_C3HxB6_Li2008.xlsx
CSV file:   Li2008_C3HxB6_B37_Data.csv
Readme / text file:   readme_Li2008.txt
QC plots, figures, etc.:   QCReport_Li2008.pdf