1. Shimomura K, Low-Zeddies SS, King DP, Steeves TD, Whiteley A, Kushla J, Zemenides PD, Lin A, Vitaterna MH, Churchill GA, Takahashi JS. Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice.
Genome Res. 2001 Jun;11(6):959-80.
2. Kumar V, Kim K, Joseph C, Thomas LC, Hong H, Takahashi JS. Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants.
Proc Natl Acad Sci U S A. 2011 Sep 13;108 Suppl 3:15557-64. doi: 10.1073/pnas.1107726108. Epub 2011 Sep 6.
3. Kumar V, Kim K, Joseph C, Kourrich S, Yoo SH, Huang HC, Vitaterna MH, de Villena FP, Churchill G, Bonci A, Takahashi JS. C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response.
Science. 2013 Dec 20;342(6165):1508-12. doi: 10.1126/science.1245503.
Open field test. Locomotor, anxiety-related, circadian behavior. Baseline and after cocaine i.p. |
Investigators |
Vivek Kumar The Jackson Laboratory, Bar Harbor, ME |
Participants | Kim K, Joseph C, Kourrich S, Yoo SH, Huang HC, Vitaterna MH, de Villena FP, Churchill G, Bonci A, Takahashi JS |
Contact | Vivek Kumar vivek.kumar@jax.org |
Affiliated Center | QTL Archive |
Acknowledgements | We thank A. Khan and W. Khan for genotyping help; A. M. Wissman, J. Gibson, and K. Huber for help with diolistics; C. Olker for behavioral testing; C. Cowan for advice on sensitization; M. Strobel for C57BL/6 substrain DNA; S. Padrick, B. Chen, and M. Rosen for WRC reagents and advice; T. Keane (Sanger Centre) for access to sequencing data; N. Kumar and I. Kornblum for technical help; and O. Hermanson and P. Lowrey for advice on manuscript. V.K. was funded through National Research Service Award F32DA024556 from NIDA. NIH grant U01MH61915 funded J.S.T. J.S.T. is an Investigator and S.H.Y. and V.K. were associates in the Howard Hughes Medical Institute. |
QTL Archive data set | |
MPD identifiers | Kumar1 MPD:290 |
No updates/corrections. Initial release date: 07/2014. |
Data set |
Procedure / Protocol |
Treatment |
Phenotype Measure / Variable (click to view) |
Panel |
No. of Strains |
Sex |
Age |
Sample Size (Avg)
|
||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
circadian wheel running | cocaine | cocaine response over 30 minutes; data are averaged in 5 minute bins and then summed over 30 minutes [cm x 100] 1sum_5min_avg 29001 | QTL population | both | N=122 | |||||||
circadian wheel running | cocaine | cocaine response over 60 minutes; data are averaged in 5 minute bins and then summed over 60 minutes [cm x 100] 1sum_60min 29002 | QTL population | both | N=122 | |||||||
circadian wheel running | (none) | average speed over 30 minutes of baseline [cm x 100 / min] 1baseline_avg 29003 | QTL population | both | N=122 | |||||||
circadian wheel running | cocaine | average speed over 30 minutes after cocaine response [cm x 100 / min] 130avg 29004 | QTL population | both | N=122 | |||||||
circadian wheel running | cocaine | net response–baselineavg subtracted from 30avg [cm x 100 / min] 1resp-baseline 29005 | QTL population | both | N=122 | |||||||
circadian wheel running | (none) | circadian period [h] Tau1_(ChiSq) 29006 | QTL population | both | N=122 | |||||||
circadian wheel running | (none) | amplitude Power_FFT 29007 | QTL population | both | N=122 | |||||||
circadian wheel running | (none) | revolutions per minute on wheels [n/min] Avg_Counts 29008 | QTL population | both | N=122 | |||||||
open field test | (none) | total distance traveled during test [cm x 100] T1TotalDist 29009 | QTL population | both | N=122 | |||||||
open field test | (none) | distance traveled in corner [cm x 100] T1CornerDist 29010 | QTL population | both | N=122 | |||||||