Lyons3: Identification of QTLs to determine cholesterol levels in 129S1/SvImJ and RIIIS/J F2 intercross (2004)

Lyons MA, Korstanje R, Li R, Walsh KA, Churchill GA, Carey MC, Paigen B. Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice. Physiol Genomics. 2004 Apr 13;17(2):114-21.   PubMed 14872007  


     
Lyons3 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants M A Lyons
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Korstanje R, Li R, Walsh KA, Carey MC, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH DK51568, DK36588, DK52911, DK34854, HL66611, CA34196; National Health and Medical Research Council of Australia (222913), American Physiological Society, American Liver Foundation
Project type QTL Archive data set
MPD identifiersLyons3     MPD:146
Data changelog No updates/corrections.       Initial release date: 07/2011.
An intercross of NZB/BlNJ and SM/J was generated to identify cholesterol gallstone susceptibility loci. F2 progeny were administered a high-fat (15%) diet for 18 wks and examined for gallstone formation. Gallstones were characterized qualitatively and quantitatively. Mice were fasted prior to sample collection. For detailed protocols see Lyons et al 2005.


QTL data set parameters:
Progenitor strains 129S1/SvImJ     RIIIS/J    
Cross direction notation(RIIIS x 129) F1 x (RIIIS x 129) F1; (129 x RIIIS) F1 x (129 x RIIIS) F1
Cross typeF2 reciprocal intercross
Population size 0 ♀     330 ♂
Age14-20wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Chol10   Chol11   Hdlq17   Hdlq18   Hdlq5   Nhdlq3  


Project / data set:   Lyons3     a.k.a. Lyons_2004
Excel file:   Data_Description_RIIISx129_Lyons2004.xlsx
CSV file:   Lyons2004_RIIISx129_B37_Data.csv
Readme / text file:   readme_Lyons2004.txt
QC plots, figures, etc.:   QCReport_Lyons2004.pdf