MPD: Data set: Guay-Woodford1

Guay-Woodford1: Kidney parameters predicting renal cystic disease severity in F2 progeny of BALB/c-Bicc1jcpk-bpk and CAST/EiJ (2000)

Guay-Woodford LM, Wright CJ, Walz G, Churchill GA. Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model. J Am Soc Nephrol. 2000 Jul;11(7):1253-60. PubMed 10864581

Guay-Woodford1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Guay-Woodford1 measures:

Investigators	L M Guay-Woodford Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Guay-Woodford LM, Wright CJ, Walz G, Churchill GA
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Funding provided by NIH DK51034
Project type	QTL Archive data set
MPD identifiers	Guay-Woodford1 MPD:107
Data changelog	No updates/corrections. Initial release date: 01/2008.

An intercross between BALB/c-Bicc1^jcpk-bpk and CAST/EiJ was generated to identify QTLs that modulate renal cystic disease severity. Kidney parameters were measured in F2 (bpk/bpk) mice at 12-16 days of age. For detailed protocols see Guay-Woodford et al 2000.

QTL data set parameters:

Progenitor strains	BALB/c-Bicc1jcpk-bpk CAST/EiJ
Cross direction notation	(BALBxCAST) F1 x (BALBxCAST) F1
Cross type	F2 intercross
Population size	144 ♀ 0 ♂
Notes	Sex not specified; arbitrarily set to female. Data are from F2-/- pups.
Age	2wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Guay-Woodford1	body size and weight	(none)	body length from crown to rump (CR) [cm] body_length 10701	QTL population	f	2wks	N=144

Guay-Woodford1	organ dimensions	(none)	length of kidney [mm] kidney_length 10702	QTL population	f	2wks	N=144

Guay-Woodford1	organ dimensions	(none)	kidney length normalized to body length [ratio] K_CR 10703	QTL population	f	2wks	N=144

Guay-Woodford1	histopathology	(none)	renal cystic disease severity [score] severity 10704	QTL population	f	2wks	N=144

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Rencd

Project / data set: Guay-Woodford1 a.k.a. Guay-Woodford_2000
Excel file: Data_Description_BALBxCAST_Guay-Woodford2000.xlsx
CSV file: Guay-Woodford2000_BALBxCAST_B37_Data.csv
Readme / text file: readme_Guay-Woodford2000.txt
QC plots, figures, etc.: QCReport_Guay-Woodford2000.pdf