MPD: Data set: Kim1

Kim1: Genetic analysis of non-insulin-dependent diabetes in backcross progeny between TallyHo and C57BL/6J strains (2001)

Kim JH, Sen S, Avery CS, Simpson E, Chandler P, Nishina PM, Churchill GA, Naggert JK. Genetic analysis of a new mouse model for non-insulin-dependent diabetes. Genomics. 2001 Jun 15;74(3):273-86. PubMed 11414755

Kim1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Kim1 measures:

MA:0000059 blood
MA:0002481 fat pad
MA:0002548 inguinal fat pad
MA:0002549 retroperitoneal fat pad
MA:0002550 epididymal fat pad
MP:0000188 abnormal circulating glucose level
MP:0001259 abnormal body weight
MP:0001560 abnormal circulating insulin level
MP:0005334 abnormal fat pad morphology
MP:0005336 abnormal inguinal fat pad morphology
MP:0005337 abnormal retroperitoneal fat pad morphology
MP:0006319 abnormal epididymal fat pad morphology
MP:0006320 abnormal interscapular fat pad morphology
MP:0008903 abnormal mesenteric fat pad morphology
VT:0000188 blood glucose amount
VT:0001259 body mass
VT:0001560 blood insulin amount
VT:0005334 fat pad morphology trait
VT:0010421 epididymal fat pad mass
VT:0010424 inguinal fat pad mass
VT:0010425 interscapular fat pad mass
VT:0010427 mesenteric fat pad mass
VT:0010430 retroperitoneal fat pad mass

Investigators	J H Kim Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Sen S, Avery CS, Simpson E, Chandler P, Nishina PM, Naggert JK
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	This work was supported by National Institutes of Health Grant DK-46977 (J.K.N.) and American Heart Association Postdoctoral Fellowship Award 9820036T (J.H.K.). Institutional shared services were supported by National Cancer Institute Cancer Center Grant CA-34196.
Project type	QTL Archive data set
MPD identifiers	Kim1 MPD:114
Data changelog	No updates/corrections. Initial release date: 09/2011.

The TallyHo (TH) mouse has many diabetes syndromes and this strain is an established model for non-insulin-dependent diabetes mellitus (NIDDM) research. To identify the QTLs linked to hyperglycemia, the male progeny obtained from backcrosses between C57BL/6J and TH, CAST and TH were used to do genetic analysis. This is the backcross data of C57BL/6J and TH strain. A genome-wide scan revealed three QTLs linked to hyperglycemia and one major QTL was mapped to chromosome 19. Additionally, gene–gene interactions contributing to hyperglycemia were also observed from the data analysis. For detailed protocols see Kim et al 2005.

QTL data set parameters:

Progenitor strains	C57BL/6J TALLYHO/JngJ
Cross direction notation	(B6 x TH) x TH
Cross type	Backcross
Population size	0 ♀ 206 ♂

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Kim1	metabolic panel	(none)	mean of 3 non-fasted plasma glucose levels measurements [mg/dL] Mean_glucose 11401	QTL population	m	26wks	N=206

Kim1	body weight	(none)	body weight measured at 20 wks [g] Body_weight 11402	QTL population	m	20wks	N=206

Kim1	hormone quantification	(none)	non-fasted insulin level [ng/mL] Insulin 11403	QTL population	m	26wks	N=206

Kim1	fat pad weights	(none)	inguinal fat pad weight [g] Inguinal 11404	QTL population	m	26wks	N=206

Kim1	fat pad weights	(none)	epididymal fat pad weight [g] Epididymal 11405	QTL population	m	26wks	N=206

Kim1	fat pad weights	(none)	mesenteric fat pad weight [g] Mesenteric 11406	QTL population	m	26wks	N=206

Kim1	fat pad weights	(none)	retroperitoneal fat pad weight [g] Retroperitoreal 11407	QTL population	m	26wks	N=206

Kim1	fat pad weights	(none)	subscapular fat pad weight [g] Subcutaneous 11408	QTL population	m	26wks	N=206

Kim1	fat pad weights	(none)	total five fat pad weight [g] Total_fat 11409	QTL population	m	26wks	N=206

Kim1	body weight	(none)	body weight of mouse carcass at week 26 [g] Carcass_WT 11410	QTL population	m	26wks	N=206

Kim1	fat pad weights	(none)	sum of five fat pad weights (g)/body weight (g) without the five fat pads [ratio] Adiposity_Index 11411	QTL population	m	26wks	N=206

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Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Tabw Tafat Tanidd1 Tanidd2 Tanidd3

Project / data set: Kim1 a.k.a. Kim_2001
Excel file: Data_Description_B6xTH_BC_Kim2001.xlsx
CSV file: Kim2001_B6xTH_BC_B37_Data.csv
Readme / text file: readme_Kim2001.txt
QC plots, figures, etc.: QCReport_Kim2001.pdf