Kim1: Genetic analysis of non-insulin-dependent diabetes in backcross progeny between TallyHo and C57BL/6J strains (2001)

Kim JH, Sen S, Avery CS, Simpson E, Chandler P, Nishina PM, Churchill GA, Naggert JK. Genetic analysis of a new mouse model for non-insulin-dependent diabetes. Genomics. 2001 Jun 15;74(3):273-86.   PubMed 11414755  


       
The TallyHo (TH) mouse has many diabetes syndromes and this strain is an established model for non-insulin-dependent diabetes mellitus (NIDDM) research. To identify the QTLs linked to hyperglycemia, the male progeny obtained from backcrosses between C57BL/6J and TH, CAST and TH were used to do genetic analysis. This is the backcross data of C57BL/6J and TH strain. A genome-wide scan revealed three QTLs linked to hyperglycemia and one major QTL was mapped to chromosome 19. Additionally, gene–gene interactions contributing to hyperglycemia were also observed from the data analysis. For detailed protocols see Kim et al 2005.

Note on studied population: TallyHo and C57BL/6J backcross progeny

Procedures conducted:
• study archive  Glucose, insulin, body and fat pad weights.

Kim1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators J H Kim
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Sen S, Avery CS, Simpson E, Chandler P, Nishina PM, Naggert JK
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported by National Institutes of Health Grant DK-46977 (J.K.N.) and American Heart Association Postdoctoral Fellowship Award 9820036T (J.H.K.). Institutional shared services were supported by National Cancer Institute Cancer Center Grant CA-34196.
Project type QTL Archive data set
MPD identifiersKim1     MPD:114
Data changelog No updates/corrections.       Initial release date: 09/2011.
QTL data set parameters:
Progenitor strains C57BL/6J     TALLYHO/JngJ    
Cross direction notation(B6 x TH) x TH
Cross typeBackcross
Population size 0 ♀     206 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Tabw   Tafat   Tanidd1   Tanidd2   Tanidd3  


Project / data set:   Kim1     a.k.a. Kim_2001
Excel file:   Data_Description_B6xTH_BC_Kim2001.xlsx
CSV file:   Kim2001_B6xTH_BC_B37_Data.csv
Readme / text file:   readme_Kim2001.txt
QC plots, figures, etc.:   QCReport_Kim2001.pdf