Gatti2: QTL mapping of neutrophil counts in Diversity Outbred population (2014)

Gatti DM, Svenson KL, Shabalin A, Wu LY, Valdar W, Simecek P, Goodwin N, Cheng R, Pomp D, Palmer A, Chesler EJ, Broman KW, Churchill GA. Quantitative trait locus mapping methods for diversity outbred mice. G3 (Bethesda). 2014 Sep 18;4(9):1623-33. doi: 10.1534/g3.114.013748.   PubMed 25237114  


       
Mapping of neutrophil counts in whole blood using 742 JAX Diversity Outbred mice (410 female, 332 male). Males (1025 +/- 427, mean +/- s.d.) had higher mean neutrophil counts than females (838 +/- 422). The trait has an estimated heritability of 0.132.

Procedures conducted:
• study archive  Whole blood neutrophil count and white cell count.

Gatti2 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators Daniel M Gatti       The Jackson Laboratory,  Bar Harbor, ME
Participants Svenson KL, Shabalin A, Wu L, Valdar W, Simecek P, Goodwin N, Cheng R, Pomp D, Palmer A, Chesler EJ, Broman K, Churchill GA
ContactDaniel M Gatti     Dan.Gatti@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported in part by National Institutes of Health grants P50 GM076468 and R01 GM070683 (to GAC), R01 GM074244 (to KWB) and RC1DK087346, DK076050, DK056350 (to DP).
Project type QTL Archive data set
MPD identifiersGatti2     MPD:289
Data changelog No updates/corrections.       Initial release date: 04/2014.
QTL data set parameters:
Progenitor strains CC8 founder strains    
Cross typeDiversity Outbred
Population size 410 ♀     332 ♂
Age10-12wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Gatti2 complete blood count (none) white blood cell counts   [thousands/µL]  WBC   28901 DO population both 10-12wks N=371
Gatti2 complete blood count (none) neutrophil counts   [n/µL]  NEUR   28902 DO population both 10-12wks N=371



Project / data set:   Gatti2     a.k.a. Gatti_2014
Excel file:   Data_Description_Gatti_2014.xlsx
CSV file:   Gatti_2014_geno.csv
CSV file:   Gatti_2014_pheno.csv
Large zipped data set:   Gatti_2014.zip