Mahler M, Most C, Schmidtke S, Sundberg JP, Li R, Hedrich HJ, Churchill GA. Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis.
Genomics. 2002 Sep;80(3):274-82.
Colitis susceptibility. Colon histopathology, spleen weight. |
Investigators |
M Mahler Gary A Churchill The Jackson Laboratory, Bar Harbor, ME |
Participants | Most C, Schmidtke S, Sundberg JP, Li R, Hedrich HJ |
Contact | Gary A Churchill gary.churchill@jax.org |
Affiliated Center | QTL Archive |
Acknowledgements | Funding provided by NIH DK44240, CA34196; and the Deutsche Forschungsgemeinschaft |
QTL Archive data set | |
MPD identifiers | Mahler1 MPD:121 |
No updates/corrections. Initial release date: 01/2008. |
Cross 1: (C3H x B6) x B6 backcross Mahler1 | |
Progenitor strains | B6.Il10-/- C3H.Il10-/- |
Cross direction notation | (C3H x B6) x B6 |
Cross type | Backcross |
Population size | 100 ♀ 103 ♂ |
Notes | N2 progeny |
Age | 6wks |
Progenitor strains | B6.Il10-/- C3H.Il10-/- |
Cross type | None |
Population size | None ♀ None ♂ |
Age | 6wks |
Data set |
Procedure / Protocol |
Treatment |
Phenotype Measure / Variable (click to view) |
Panel |
No. of Strains |
Sex |
Age |
Sample Size (Avg)
|
||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
organ weights | (none) | spleen to body weight ratio, first Principal Component [ratio] SplBW 12101 | QTL population | both | N=102 | |||||||
histopathology | (none) | cecum assessment, first Principal Component CecumPC1 12102 | QTL population | both | N=102 | |||||||
histopathology | (none) | proximal colon assessment, first Principal Component ProxPC1 12103 | QTL population | both | N=102 | |||||||
histopathology | (none) | middle colon assessment, first Principal Component MidPC1 12104 | QTL population | both | N=102 | |||||||
histopathology | (none) | distal colon assessment, first Principal Component DistPC1 12105 | QTL population | both | N=102 | |||||||
histopathology | (none) | ulceration (score 0-4, increasing severity), first Principal Component Ulceration-PC1 12106 | QTL population | both | N=102 | |||||||
histopathology | (none) | ulceration (score 0-4, increasing severity), second Principal Component Ulceration-PC2 12107 | QTL population | both | N=102 | |||||||