Chesler6: Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J x 129S1/SvImJ inbred mouse cross (2012)

Chesler EJ, Plitt A, Fisher D, Hurd B, Lederle L, Bubier JA, Kiselycznyk C, Holmes A. Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J × 129S1/SvImJ inbred mouse cross. Mamm Genome. 2012 Jun;23(5-6):305-2Epub 2012 Feb 28.   PubMed 22371272  


     
Chesler6 downloads
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Participants Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
With: Plitt A, Fisher D, Hurd B, Lederle L, Bubier JA, Kiselycznyk C, Holmes A
ContactElissa J Chesler     elissa.chesler@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsResearch supported by the National Institute of Alcohol Abuse and Alcoholism Intramural Research Program (Z01 AA000411). EJC is supported by The Jackson Laboratory and R01 AA18776.
Project type QTL Archive data set
MPD identifiersChesler6     MPD:271
Data changelog No updates/corrections.       Initial release date: 03/2012.
Individual variation in sensitivity to acute ethanol (EtOH) challenge is associated with alcohol drinking and abuse. Inbred strain C57BL/6J (B6) and 129S1/SvImJ (S1) showed different responses on certain measures of acute EtOH intoxication. To gain insight into genetic factors contributing to these differences, a QTL analysis of EtOH traits was performed in B6x129S1 F2 population. The result revealed several additive and interacting loci, and the QTLs for different EtOH phenotypes were largely non-overlapping. For detailed protocols, see Chesler et al 2012.


QTL data set parameters:
Progenitor strains 129S1/SvImJ     C57BL/6J    
Cross typeF2 reciprocal intercross
Population size 178 ♀     195 ♂
Notesone mouse was missing sex infomation
Age9-34wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Chesler6 27101 body weight (none) mouse body weight   [g]  B_wght QTL population both 9-34wks N=187
Chesler6 27102 rotarod (none) rotarod: initial trial performance (latency to fall in seconds)   [second]  Rotarod_base QTL population both 9-34wks N=187
Chesler6 27103 rotarod (none) rotarod: final minus initial trial latency to fall on rotarod through 10 training trials (latency difference in seconds)   [second]  Rotarod_learn QTL population both 9-34wks N=187
Chesler6 27104 rotarod ethanol rotarod: two trial post alcohol average minus pre trial latency to fall off rotarod (latency difference in seconds)   [second]  Rotarod_atax QTL population both 9-34wks N=187
Chesler6 27105 body temperature ethanol post alcohol minus pre alcohol body temperature (degrees Celsius)   [° C]  Hypotherm QTL population both 9-34wks N=187
Chesler6 27106 behavior observation ethanol alcohol induced Loss of Righting Reflex (latency to return of reflex in seconds)   [second]  LORR QTL population both 9-34wks N=187
Chesler6 27107 alcohol quantification ethanol Blood Ethanol Concentration at return of righting reflex (latency to return in seconds)   [mg/mL]  LORR_BEC QTL population both 9-34wks N=187
Chesler6 27108 rotarod (none) rotarod: average performance over 10 training trials. (latency to fall in seconds)   [second]  Avg1to10 QTL population both 9-34wks N=187
Chesler6 27109 rotarod ethanol rotarod: first alcohol trial performance (latency to fall in seconds)   [second]  RotaTest1 QTL population both 9-34wks N=187



Project / data set:   Chesler6     a.k.a. Chesler_2012
Excel file:   Data_Description_B6x129S_Chesler2012.xlsx
CSV file:   Chesler2012_B6x129S_B37_Data.csv
Readme / text file:   readme_Chesler2012.txt
QC plots, figures, etc.:   Chr12RFplot_Chesler2012.png
QC plots, figures, etc.:   MapComparison_Chesler2012.png
QC plots, figures, etc.:   Mapplot_Chesler2012.png
QC plots, figures, etc.:   MissingGeno_Chesler2012.png
QC plots, figures, etc.:   RFplot_Chesler2012.png