Chesler6: Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J x 129S1/SvImJ inbred mouse cross (2012)

Chesler EJ, Plitt A, Fisher D, Hurd B, Lederle L, Bubier JA, Kiselycznyk C, Holmes A. Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J × 129S1/SvImJ inbred mouse cross. Mamm Genome. 2012 Jun;23(5-6):305-2Epub 2012 Feb 28.   PubMed 22371272  


       
Individual variation in sensitivity to acute ethanol (EtOH) challenge is associated with alcohol drinking and abuse. Inbred strain C57BL/6J (B6) and 129S1/SvImJ (S1) showed different responses on certain measures of acute EtOH intoxication. To gain insight into genetic factors contributing to these differences, a QTL analysis of EtOH traits was performed in B6x129S1 F2 population. The result revealed several additive and interacting loci, and the QTLs for different EtOH phenotypes were largely non-overlapping. For detailed protocols, see Chesler et al 2012.

Note on studied population: C57BL/6J x 129S1/SvImJ

Procedures conducted:
• study archive  Sensitivity to ethanol. Baseline and ethanol.

Chesler6 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators Elissa J Chesler       The Jackson Laboratory,  Bar Harbor, ME
Participants Plitt A, Fisher D, Hurd B, Lederle L, Bubier JA, Kiselycznyk C, Holmes A
ContactElissa J Chesler     elissa.chesler@jax.org
Affiliated CenterQTL Archive
AcknowledgementsResearch supported by the National Institute of Alcohol Abuse and Alcoholism Intramural Research Program (Z01 AA000411). EJC is supported by The Jackson Laboratory and R01 AA18776.
Project type QTL Archive data set
MPD identifiersChesler6     MPD:271
Data changelog No updates/corrections.       Initial release date: 03/2012.
QTL data set parameters:
Progenitor strains 129S1/SvImJ     C57BL/6J    
Cross typeF2 reciprocal intercross
Population size 178 ♀     195 ♂
Notesone mouse was missing sex infomation
Age9-34wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Chesler6 body weight (none) mouse body weight   [g]  B_wght   27101 QTL population both 9-34wks N=186
Chesler6 rotarod (none) latency to fall, initial trial   [s]  Rotarod_base   27102 QTL population both 9-34wks N=186
Chesler6 rotarod (none) latency difference, final minus initial trial latency to fall on rotarod through 10 training trials   [s]  Rotarod_learn   27103 QTL population both 9-34wks N=186
Chesler6 rotarod ethanol latency difference, two trial post alcohol average minus pre trial latency to fall off rotarod   [s]  Rotarod_atax   27104 QTL population both 9-34wks N=186
Chesler6 body temperature ethanol post alcohol minus pre alcohol body temperature   [° C]  Hypotherm   27105 QTL population both 9-34wks N=186
Chesler6 behavior observation ethanol alcohol induced loss of righting reflex, latency to return of reflex   [s]  LORR   27106 QTL population both 9-34wks N=186
Chesler6 alcohol quantification ethanol blood ethanol concentration at return of righting reflex   [mg/mL]  LORR_BEC   27107 QTL population both 9-34wks N=186
Chesler6 rotarod (none) average latency to fall over 10 training trials   [second]  Avg1to10   27108 QTL population both 9-34wks N=186
Chesler6 rotarod ethanol latency to fall, first alcohol trial   [s]  RotaTest1   27109 QTL population both 9-34wks N=186

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Eih3   Eih4   Eih5   Elorr3  


Project / data set:   Chesler6     a.k.a. Chesler_2012
Excel file:   Data_Description_B6x129S_Chesler2012.xlsx
CSV file:   Chesler2012_B6x129S_B37_Data.csv
Readme / text file:   readme_Chesler2012.txt
QC plots, figures, etc.:   Chr12RFplot_Chesler2012.png
QC plots, figures, etc.:   MapComparison_Chesler2012.png
QC plots, figures, etc.:   Mapplot_Chesler2012.png
QC plots, figures, etc.:   MissingGeno_Chesler2012.png
QC plots, figures, etc.:   RFplot_Chesler2012.png