Yuan5: QTL analysis of circulating adhesion molecules in apoE-/- mice (2008)
Yuan Z, Su Z, Miyoshi T, Rowlan JS, Shi W. Quantitative trait locus analysis of circulating adhesion molecules in hyperlipidemic apolipoprotein E-deficient mice.
Mol Genet Genomics. 2008 Nov;280(5):375-83. Epub 2008 Aug 13.
Yuan5 downloads
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QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Ontology terms mapped to Yuan5 measures:
| Investigators |
Z Yuan Gary A Churchill The Jackson Laboratory, Bar Harbor, ME |
| Participants | Su Z, Miyoshi T, Rowlan JS, Shi W |
| Contact | Gary A Churchill gary.churchill@jax.org |
| Affiliated Center | QTL Archive |
| Acknowledgements | Grant: The current study was supported by the National Institutes of Health grant HL75433 and by the NHLBI Mammalian Genotyping Service (contract HV48141) for the genotyping. |
| QTL Archive data set | |
| MPD identifiers | Yuan5 MPD:211 |
| No updates/corrections. Initial release date: 03/2011. |
Circulating soluble adhesion molecules are useful markers to predict several clinical conditions. To determine genetic factors influencing plasma levels of VCAM-1 and P-selectin, authors performed QTL analysis on an intercross between B6 and C3H strains deficient in apolipoprotein E. 234 female F2 mice were selected to do the experiments, and the analysis results indicate VCAM-1 and P-selectin levels are complex traits regulated by multiple genes, at least partially, by acting on body weight and lipid metabolism in hyperlipidemic apoE-/- mice.
| Progenitor strains | B5.apoE-/- C3H.apoE-/- |
| Cross direction notation | (B6xC3H) F1 x (B6xC3H) F1 |
| Cross type | F2 intercross |
| Population size | 234 ♀ 0 ♂ |
| Age | 18wks |
Project / data set: Yuan5 a.k.a. Yuan_2008
Excel file: Data_Description_B6xC3H_Yuan2008.xlsx
CSV file: Yuan2008_B6xC3H_B37_Data.csv
Readme / text file: readme_Yuan2008.txt