Solberg1: Depression-like behavior research in the reciprocal intercross of WKY and Fisher 344 rat strain (2004)

Solberg LC, Churchill GA

       
A reciprocal intercross of rat strain Wistar-Kyoto (WKY) and Fisher 344 (F344) was generated to identify quantitative trait locus (QTL) for depression-like behavior traits. The F2 generation was subjected to the forced swim test (FST) to measure the time of immobility, climbing and swimming. For detailed protocols, see Solberg et al. 2004.

This was a cross between rat strains thus no B37 map for data, the posted data is as provided by the authors. For more info on these rat strains please see RGD.

These tests were performed: 1) DB (15 minutes defensive burying test); 2) FST (5 minutes forced swim test); 3) OFT (10 minutes open-field test).

Note on studied population: WKY and Fisher 344 rat strain intercross

Procedures conducted:
• study archive  Open field test, forced swim test, defensive burying task.

Solberg1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Investigators L C Solberg
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsPlease see the Excel file.
Project type QTL Archive data set
MPD identifiersSolberg1     MPD:150
Data changelog No updates/corrections.       Initial release date: 12/2010.
QTL data set parameters:
Cross direction notation(FxW) F1 x (FxW) F1; (WxF) F1 x (WxF) F1
Cross typeF2 reciprocal intercross
Population size 223 ♀     263 ♂
Notesrat population


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Select table page: First Prev 1 - 10 / 21 (21) Next Last
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Solberg1 defensive burying task (none) number of times a rat gets shocked in the defensive burying test   [n]  DBshocks   15001 QTL population both 11wks N=243
Solberg1 defensive burying task (none) number of times a rat approaches the prod in the defensive burying test   [n]  DBapproaches   15002 QTL population both 11wks N=243
Solberg1 defensive burying task (none) latency to begin burying in the defensive burying test   [min]  DBlatencytobury   15003 QTL population both 11wks N=243
Solberg1 defensive burying task (none) duration of burying in the defensive burying test   [sec]  DBdurationofburying   15004 QTL population both 11wks N=243
Solberg1 defensive burying task (none) number of rears in the defensive burying test   [n]  DBrears   15005 QTL population both 11wks N=243
Solberg1 defensive burying task (none) time spent grooming in the defensive burying test   [sec]  DBgroomtime   15006 QTL population both 11wks N=243
Solberg1 forced swim test (none) duration of climbing in FST   [sec]  FSTclimbing   15007 QTL population both 11wks N=243
Solberg1 forced swim test (none) duration of immobility in FST   [sec]  FSTimmobility   15008 QTL population both 11wks N=243
Solberg1 hormone quantification (none) thyroid-stimulating hormone   [ng/mL]  TSH   15009 QTL population both 15wks N=243
Solberg1 open field test (none) number of inner lines crossed in the OFT   [n]  OFTinnerlinecrossing   15010 QTL population both 11wks N=243
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Project / data set:   Solberg1     a.k.a. Solberg_2004
Excel file:   ._Data_Description_FxW_Solberg2004.xlsx
Excel file:   Data_Description_FxW_Solberg2004.xlsx
CSV file:   Solberg2004_F344xWKY_Data.csv
Readme / text file:   readme_Solberg2004.txt


References   (chronological)

1.   Ahmadiyeh N, Churchill GA, Shimomura K, Solberg LC, Takahashi JS, Redei EE. X-linked and lineage-dependent inheritance of coping responses to stress. Mamm Genome. 2003 Nov;14(11):748-57.   PubMed 14722724  

2.   Solberg LC, Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Churchill GA, Takahashi JS, Redei EE. Sex- and lineage-specific inheritance of depression-like behavior in the rat. Mamm Genome. 2004 Aug;15(8):648-62.   PubMed 15457344  

3.   Baum AE, Solberg LC, Kopp P, Ahmadiyeh N, Churchill G, Takahashi JS, Jameson JL, Redei EE. Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat. Endocrinology. 2005 Feb;146(2):870-8. Epub 2004 Oct 28.   PubMed 15514085  

4.   Ahmadiyeh N, Churchill GA, Solberg LC, Baum AE, Shimomura K, Takahashi JS, Redei EE. Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress. Behav Genet. 2005 Mar;35(2):189-98.   PubMed 15685431  

5.   Baum AE, Solberg LC, Churchill GA, Ahmadiyeh N, Takahashi JS, Redei EE. Test- and behavior-specific genetic factors affect WKY hypoactivity in tests of emotionality. Behav Brain Res. 2006 May 15;169(2):220-30. Epub 2006 Feb 20.   PubMed 16490266  

6.   Solberg LC, Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Takahashi JS, Churchill GA, Redei EE. Genetic analysis of the stress-responsive adrenocortical axis. Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8.   PubMed 16895972  

7.   Solberg Woods LC, Ahmadiyeh N, Baum A, Shimomura K, Li Q, Steiner DF, Turek FW, Takahashi JS, Churchill GA, Redei EE. Identification of genetic loci involved in diabetes using a rat model of depression. Mamm Genome. 2009 Aug;20(8):486-97. Epub 2009 Aug 22.   PubMed 19697080     FullText