Solberg1: Depression-like behavior research in the reciprocal intercross of WKY and Fisher 344 rat strain (2004)

Solberg LC, Churchill GA

Solberg1 downloads
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Investigators L C Solberg
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
ContactGary A Churchill
Affiliated CenterQTL Archive
AcknowledgementsPlease see the Excel file.
Project type QTL Archive data set
MPD identifiersSolberg1     MPD:150
Data changelog No updates/corrections.       Initial release date: 12/2010.
A reciprocal intercross of rat strain Wistar-Kyoto (WKY) and Fisher 344 (F344) was generated to identify quantitative trait locus (QTL) for depression-like behavior traits. The F2 generation was subjected to the forced swim test (FST) to measure the time of immobility, climbing and swimming. For detailed protocols, see Solberg et al. 2004.

This was a cross between rat strains thus no B37 map for data, the posted data is as provided by the authors. For more info on these rat strains please see RGD.

These tests were performed: 1) DB (15 minutes defensive burying test); 2) FST (5 minutes forced swim test); 3) OFT (10 minutes open-field test).

QTL data set parameters:
Cross direction notation(FxW) F1 x (FxW) F1; (WxF) F1 x (WxF) F1
Cross typeF2 reciprocal intercross
Population size 223 ♀     263 ♂
Notesrat population

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Project / data set:   Solberg1     a.k.a. Solberg_2004
Excel file:   ._Data_Description_FxW_Solberg2004.xlsx
Excel file:   Data_Description_FxW_Solberg2004.xlsx
CSV file:   Solberg2004_F344xWKY_Data.csv
Readme / text file:   readme_Solberg2004.txt

References   (chronological)

1.   Ahmadiyeh N, Churchill GA, Shimomura K, Solberg LC, Takahashi JS, Redei EE. X-linked and lineage-dependent inheritance of coping responses to stress. Mamm Genome. 2003 Nov;14(11):748-57.   PubMed 14722724  

2.   Solberg LC, Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Churchill GA, Takahashi JS, Redei EE. Sex- and lineage-specific inheritance of depression-like behavior in the rat. Mamm Genome. 2004 Aug;15(8):648-62.   PubMed 15457344  

3.   Baum AE, Solberg LC, Kopp P, Ahmadiyeh N, Churchill G, Takahashi JS, Jameson JL, Redei EE. Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat. Endocrinology. 2005 Feb;146(2):870-8. Epub 2004 Oct 28.   PubMed 15514085  

4.   Ahmadiyeh N, Churchill GA, Solberg LC, Baum AE, Shimomura K, Takahashi JS, Redei EE. Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress. Behav Genet. 2005 Mar;35(2):189-98.   PubMed 15685431  

5.   Baum AE, Solberg LC, Churchill GA, Ahmadiyeh N, Takahashi JS, Redei EE. Test- and behavior-specific genetic factors affect WKY hypoactivity in tests of emotionality. Behav Brain Res. 2006 May 15;169(2):220-30. Epub 2006 Feb 20.   PubMed 16490266  

6.   Solberg LC, Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Takahashi JS, Churchill GA, Redei EE. Genetic analysis of the stress-responsive adrenocortical axis. Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8.   PubMed 16895972  

7.   Solberg Woods LC, Ahmadiyeh N, Baum A, Shimomura K, Li Q, Steiner DF, Turek FW, Takahashi JS, Churchill GA, Redei EE. Identification of genetic loci involved in diabetes using a rat model of depression. Mamm Genome. 2009 Aug;20(8):486-97. Epub 2009 Aug 22.   PubMed 19697080     FullText