Karst1: Identification of the genetic determinants for intramuscular fat content and water-holding capacity in high muscle mass mice (2011)

Kärst S, Cheng R, Schmitt AO, Yang H, de Villena FP, Palmer AA, Brockmann GA. Genetic determinants for intramuscular fat content and water-holding capacity in mice selected for high muscle mass. Mamm Genome. 2011 Oct;22(9-10):530-43. Epub 2011 Jul 6.   PubMed 21732194     FullText


       
Intramuscular fat content and water-holding capacity are important traits in livestock. To identify genomic regions affecting them, the progeny of two inbred lines of the Berlin Muscle Mouse (BMMI816 and BMMI806), which have high muscle mass, were used as a QTL research model for livestock. These two strains were crossed reciprocally to generate F1, F2, and G3 intercross populations. Multiple related phenotypes have been measured and this is the data of G3 population. The linkage analyses with G3 animals revealed QTL on chromsome 7 and 2. For detailed protocols, see Karst et al 2011.

Note on studied population: BMMI816 x BMMI806 (Berlin Muscle Mouse)

Procedures conducted:
• study archive  Characterization of high-muscle-mass mice.

Karst1 downloads
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Investigators B Karst
Abraham A Palmer       University of California, San Diego,  San Diego, CA
Participants Cheng R, Schmitt AO, Yang H, de Villena FP, Brockmann GA
ContactAbraham A Palmer     aapalmer@ucsd.edu
Affiliated CenterQTL Archive
AcknowledgementsThis project was supported by the Deutsche Forschungsgemeinschaft (Project BR1285/8-1) and National Institutes of Health grant R21DA024845.
Project type QTL Archive data set
MPD identifiersKarst1     MPD:260
Data changelog No updates/corrections.       Initial release date: 11/2011.
QTL data set parameters:
Progenitor strains BMMI806     BMMI816    
Cross direction notation(816 x 806) F2 x (816 x 806) F2; (806 x 816) F2 x (806 x 816) F2
Cross typeG3 reciprocal intercross
Population size 160 ♀     172 ♂
NotesG3 progeny


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Select table page: First Prev 1 - 10 / 28 (28) Next Last
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Karst1 colony observation (none) litter size at day of weaning (day 21) (s ='small' mice; b = 'big' mice )  WG21   26001 QTL population both 3wks N=166
Karst1 colony observation (none) coat color (white = 0, black = 1)  color   26002 QTL population both 10wks N=166
Karst1 body weight (none) body weight at day 70   [g]  bwd70   26003 QTL population both 10wks N=166
Karst1 MRI (none) lean mass measured by MRI(1)   [g]  mrilean   26004 QTL population both 10wks N=166
Karst1 MRI (none) fat mass measured by MRI   [g]  mrifat   26005 QTL population both 10wks N=166
Karst1 organ weights (none) muscle mass, as the sum of 2 Musculus longissimus (ml) + 2 Musculus quadriceps (mq)   [g]  msclemass   26006 QTL population both 10wks N=166
Karst1 body weight (none) body weight at day 70, log transformed   [log(g)]  logbwd70   26007 QTL population both 10wks N=166
Karst1 MRI (none) lean mass, log transformed   [log(g)]  logmrilean   26008 QTL population both 10wks N=166
Karst1 MRI (none) fat mass, log transformed   [log(g)]  logmrifat   26009 QTL population both 10wks N=166
Karst1 organ weights (none) muscle mass, log-transformed   [log(g)]  logmsclemass   26010 QTL population both 10wks N=166
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Project / data set:   Karst1     a.k.a. Karst_2011
Excel file:   Data_Description_BMMI816x806_Karst2011.xlsx
CSV file:   Karst2011_BMMI816x806_B37_Data.csv
Readme / text file:   readme_Karst2011.txt
QC plots, figures, etc.:   QCReport_Karst2011.pdf