Clemens1: UV-induced immunosuppression in backcross mice (involving BALB/cAnNCrl and C57BL/6NCrl) (2000)

Clemens KE, Churchill G, Bhatt N, Richardson K, Noonan FP. Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci. Genes Immun. 2000;1(4):251-9.   PubMed 11196701  


       
A backcross involving BALB/cAnNCrl and C57BL/6NCrl inbred mouse strains was generated to identify QTLs involved in UV-induced immunosuppression. Backcross progeny were tested for systemic immunosuppression of a contact hypersensitivity response. Intervention: UV radiation dose 4.5 kJ/m2 for 15 min. Sensitization: trinitrochlorobenzene (TNCB). For detailed protocols see Clemens et al 2000.

Note on studied population: BALB/cAnNCrl x C57BL/6NCrl backcross

Procedures conducted:
• study archive  Immunosuppression of contact hypersensitivity after ultraviolet light exposure

Clemens1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators K E Clemens
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Bhatt N, Richardson K, Noonan FP
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThese studies were funded by NIH RO1CA53765 to FPN.
Project type QTL Archive data set
MPD identifiersClemens1     MPD:106
Data changelog No updates/corrections.       Initial release date: 01/2008.
QTL data set parameters:
Progenitor strains BALB/cAnNCrl     C57BL/6NCrl    
Cross direction notationBALB x (BALBxB6)
Cross typeBackcross
Population size 75 ♀     59 ♂
Age9-30wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Clemens1 health assessment ultraviolet light UV-induced immunosuppression of contact hypersensitivity   [%]  suppression   10601 QTL population both 9-30wks N=67

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Uvbi1   Uvbi2  


Project / data set:   Clemens1     a.k.a. Clemens_2000
Excel file:   Data_Description_BALBxB6_Clemens2000.xlsx
CSV file:   Clemens2000_BALBxB6_B37_Data.csv
Readme / text file:   ._readme.txt
Readme / text file:   readme_Clemens2000.txt
QC plots, figures, etc.:   QCReport_Clemens2000.pdf