MPD: Data set: Clemens1

Clemens1: UV-induced immunosuppression in backcross mice (involving BALB/cAnNCrl and C57BL/6NCrl) (2000)

Clemens KE, Churchill G, Bhatt N, Richardson K, Noonan FP. Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci. Genes Immun. 2000;1(4):251-9. PubMed 11196701

A backcross involving BALB/cAnNCrl and C57BL/6NCrl inbred mouse strains was generated to identify QTLs involved in UV-induced immunosuppression. Backcross progeny were tested for systemic immunosuppression of a contact hypersensitivity response. Intervention: UV radiation dose 4.5 kJ/m² for 15 min. Sensitization: trinitrochlorobenzene (TNCB). For detailed protocols see Clemens et al 2000.

Note on studied population: BALB/cAnNCrl x C57BL/6NCrl backcross

Procedures conducted:

• study archive

Immunosuppression of contact hypersensitivity after ultraviolet light exposure

Clemens1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Clemens1 measures:

Investigators	K E Clemens Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Bhatt N, Richardson K, Noonan FP
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	These studies were funded by NIH RO1CA53765 to FPN.
Project type	QTL Archive data set
MPD identifiers	Clemens1 MPD:106
Data changelog	No updates/corrections. Initial release date: 01/2008.

QTL data set parameters:

Progenitor strains	BALB/cAnNCrl C57BL/6NCrl
Cross direction notation	BALB x (BALBxB6)
Cross type	Backcross
Population size	75 ♀ 59 ♂
Age	9-30wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Clemens1	health assessment	ultraviolet light	UV-induced immunosuppression of contact hypersensitivity [%] suppression 10601	QTL population		both	9-30wks	N=67

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Uvbi1 Uvbi2

Project / data set: Clemens1 a.k.a. Clemens_2000
Excel file: Data_Description_BALBxB6_Clemens2000.xlsx
CSV file: Clemens2000_BALBxB6_B37_Data.csv
Readme / text file: ._readme.txt
Readme / text file: readme_Clemens2000.txt
QC plots, figures, etc.: QCReport_Clemens2000.pdf