Ackerman1: QTL mapping of airway hyperresponsiveness in a backcross of A/J x C3H/HeJ (2005)

De Sanctis GT, Singer JB, Jiao A, Yandava CN, Lee YH, Haynes TC, Lander ES, Beier DR, Drazen JM. Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. Am J Physiol. 1999 Dec;277(6 Pt 1):L1118-23.   PubMed 10600881  

Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR. Interacting genetic loci cause airway hyperresponsiveness. Physiol Genomics. 2005 Mar 21;21(1):105-1Epub 2005 Jan 18.   PubMed 15657107  


     
Ackerman1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants K G Ackerman
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: DeSanctis GT, Huang H, Grasemann H, Puma C, Singer JB, Jiao A, Yandava CN, Lee YH, Haynes TC, Hill AE, Lander E, Nadeau JH, Drazen JM, Beier DR
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsGrants: This work was supported by National Institutes of Health (NIH) Grant HL-36110 (to J. M. Drazen and D. R. Beier). K. G. Ackerman received postdoctoral support from NIH (T32-HL-07633 and T32-HD-40128-03); American Lung Association (G. T. De Sanctis); National Heart, Lung, and Blood Institute Grant HL-36110 (to J. M. Drazen); and a grant from the National Center for Human Genome Research (to E. S. Lander).
Project type QTL Archive data set
MPD identifiersAckerman1     MPD:156
Data changelog No updates/corrections.       Initial release date: 07/2011.
Airway hyperresponsiveness (AHR) is a key physiological component of asthma. To research the genetic basis of this complex trait, backcrosses between A/J and C3H/HeJ, A/J and C57BL/6J were generated to identify the QTLs associated with AHR. This is the data for the A/J x C3H cross with 372 female mice. For detailed protocols see Ackerman et al 2005.


QTL data set parameters:
Progenitor strains A/J     C3H/HeJ    
Cross direction notation(AxC3H) x C3H
Cross typeBackcross
Population size 372 ♀     0 ♂
Age7-8wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Ackerman1 15601 ventilator methacholine individual pulmonary resistance values, a percentage of baseline for the 100 µg/kg dose   [%]  RL100 QTL population f 7-8wks N=372
Ackerman1 15602 ventilator methacholine individual pulmonary resistance, a percentage of baseline for the 330 µg/kg dose   [%]  RL330 QTL population f 7-8wks N=372
Ackerman1 15603 ventilator methacholine individual pulmonary resistance, a percentage of baseline for the 1000 µg/kg dose   [%]  RL1000 QTL population f 7-8wks N=372
Ackerman1 15604 ventilator methacholine individual pulmonary resistance, a percentage of baseline for the 3300 µg/kg dose   [%]  RL3300 QTL population f 7-8wks N=372
Ackerman1 15605 ventilator methacholine effective doses of methacholine required for a 1.50-fold increase in RL), log transformed   [log(n)]  logED150 QTL population f 7-8wks N=372

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Bhr1   Bhr5   Bhr6  


Project / data set:   Ackerman1     a.k.a. Ackerman_2005b
Excel file:   Data_Description_AxC_BC_Ackerman2005b.xlsx
CSV file:   Ackerman2005b_AxC_BC_B37_Data.csv
Readme / text file:   readme_Ackerman2005b.txt
QC plots, figures, etc.:   QCReport_Ackerman2005b.pdf