MPD: Data set: Reifsnyder2

Reifsnyder2: Type 1 diabetes in the intercross of NOD mice and a 'genome-conditioned' NOR stock (2005)

Reifsnyder PC, Li R, Silveira PA, Churchill G, Serreze DV, Leiter EH. Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice. Genes Immun. 2005 Sep;6(6):528-38. PubMed 16015371

An intercross of NOD mice and a 'genome-conditioned' NOR stock was generated to identify additional genetic loci conditioning on the Idd13-mediated resistance. For detailed information see Reifsnyder et al 2005. Erratum for this work appeared in Genes Immun. 2006 Mar;7(2):184.

Note on studied population: NOD x NOR intercross

Procedures conducted:

• study archive

Type 1 diabetes onset.

Reifsnyder2 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Reifsnyder2 measures:

Investigators	Peter C Reifsnyder The Jackson Laboratory, Bar Harbor, ME
Participants	Li R, Silveira PA, Churchill G, Serreze DV, Leiter EH
Contact	Peter C Reifsnyder peter.reifsnyder@jax.org
Affiliated Center	QTL Archive
Acknowledgements	This work was supported by NIH grants DK27722 and DK36175. Institutional shared services were supported by National Cancer Institute Center Support Grant CA-34196.
Project type	QTL Archive data set
MPD identifiers	Reifsnyder2 MPD:176
Data changelog	No updates/corrections. Initial release date: 10/2009.

QTL data set parameters:

Progenitor strains	NOD/ShiLtJ NOR.NOD-//1
Cross direction notation	(NODxNOR) F1 x (NODxNOR) F1
Cross type	F2 intercross
Population size	185 ♀ 0 ♂
Age	12-40wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Reifsnyder2	histopathology	(none)	the week of clinical diabetes onset [n] Onset 17601	QTL population	f	12-40wks	N=185

Reifsnyder2	histopathology	(none)	insulitis score of diabetes-free mice, (from 0.002=virtually no insulitis, to 1.0=incipient diabetic) Insulitis_Index 17602	QTL population	f	12-40wks	N=185

Reifsnyder2	histopathology	(none)	first principal component of age at diabetes onset and severity/extent of insulitis Prin1 17603	QTL population	f	12-40wks	N=185

Reifsnyder2	histopathology	(none)	second principal component of age at diabetes onset and severity / extent of insulitis Prin2 17604	QTL population	f	12-40wks	N=185

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Idd25 Idd26 Idd5.2 Idd9

Project / data set: Reifsnyder2 a.k.a. Reifsnyder_2005
Excel file: Data_Description_NODxNOR_Reifsnyder2005.xlsx
CSV file: Reifsnyder2005_NODxNOR_B37_Data.csv
Readme / text file: readme_Reifsnyder2005.txt