Reifsnyder2: Type 1 diabetes in the intercross of NOD mice and a 'genome-conditioned' NOR stock (2005)

Reifsnyder PC, Li R, Silveira PA, Churchill G, Serreze DV, Leiter EH. Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice. Genes Immun. 2005 Sep;6(6):528-38.   PubMed 16015371  


       
An intercross of NOD mice and a 'genome-conditioned' NOR stock was generated to identify additional genetic loci conditioning on the Idd13-mediated resistance. For detailed information see Reifsnyder et al 2005. Erratum for this work appeared in Genes Immun. 2006 Mar;7(2):184.

Note on studied population: NOD x NOR intercross

Procedures conducted:
• study archive  Type 1 diabetes onset.

Reifsnyder2 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators Peter C Reifsnyder       The Jackson Laboratory,  Bar Harbor, ME
Participants Li R, Silveira PA, Churchill G, Serreze DV, Leiter EH
ContactPeter C Reifsnyder     peter.reifsnyder@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported by NIH grants DK27722 and DK36175. Institutional shared services were supported by National Cancer Institute Center Support Grant CA-34196.
Project type QTL Archive data set
MPD identifiersReifsnyder2     MPD:176
Data changelog No updates/corrections.       Initial release date: 10/2009.
QTL data set parameters:
Progenitor strains NOD/ShiLtJ     NOR.NOD-//1    
Cross direction notation(NODxNOR) F1 x (NODxNOR) F1
Cross typeF2 intercross
Population size 185 ♀     0 ♂
Age12-40wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
Reifsnyder2 histopathology (none) the week of clinical diabetes onset   [n]  Onset   17601 QTL population f 12-40wks N=185
Reifsnyder2 histopathology (none) insulitis score of diabetes-free mice, (from 0.002=virtually no insulitis, to 1.0=incipient diabetic)  Insulitis_Index   17602 QTL population f 12-40wks N=185
Reifsnyder2 histopathology (none) first principal component of age at diabetes onset and severity/extent of insulitis  Prin1   17603 QTL population f 12-40wks N=185
Reifsnyder2 histopathology (none) second principal component of age at diabetes onset and severity / extent of insulitis  Prin2   17604 QTL population f 12-40wks N=185

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Idd25   Idd26   Idd5.2   Idd9  


Project / data set:   Reifsnyder2     a.k.a. Reifsnyder_2005
Excel file:   Data_Description_NODxNOR_Reifsnyder2005.xlsx
CSV file:   Reifsnyder2005_NODxNOR_B37_Data.csv
Readme / text file:   readme_Reifsnyder2005.txt