Broman1: Gut length in a mouse intercross between C3HeB/FeJ and C57BL/6J, with one F1 parent carrying the Sox10Dom mutation (2006)

Owens SE, Broman KW, Wiltshire T, Elmore JB, Bradley KM, Smith JR, Southard-Smith EM. Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet. 2005 Jun 1;14(11):1549-58. Epub 2005 Apr 20.   PubMed 15843399  

Broman KW, Sen S, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA. The X chromosome in quantitative trait locus mapping. Genetics. 2006 Dec;174(4):2151-8. Epub 2006 Oct 8.   PubMed 17028340     FullText


       
A mouse intercross between C3HeBFeJ (C3) and C57BL/6J (B6), with one F1 parent carrying the Sox10Dom mutation. There are 1068 mice from reciprocal intercrosses. Over 2000 mice were generated, but only those individuals heterozygous at Sox10Dom were genotyped and included in the data set. Sox10 is on chromosome 15, and so that chromosome exhibits an unusual segregation pattern. Some mice received the mutation from their mother and some from their father. The primary phenotype is gut length (in cm). The phenotype cross indicates the cross used to generate an animal.

Note on studied population: C3HeB/FeJ x C57BL/6J intercross

Procedures conducted:
• study archive  Gut length.

Broman1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators Karl W Broman       University of Wisconsin,  Madison, WI
Participants Sen S, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA
ContactKarl W Broman     kbroman@biostat.wisc.edu
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported by a Foundation for Digestive Health and Nutrition Research Scholar Award and US National Institutes of Health grants from NINDS (NS43556) and NIDDK (DK60047) to E.M.S2.
Project type QTL Archive data set
MPD identifiersBroman1     MPD:183
Data changelog No updates/corrections.       Initial release date: 10/2009.
QTL data set parameters:
Progenitor strains B6.Sox10Dom     C3HeB/FeJ     C57BL/6J    
Cross direction notationsee Excel file
Cross typeF2 reciprocal intercross
Population size 505 ♀     563 ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Gutl1   Sox10m2   Sox10m3   Sox10m4   Sox10m5  


Project / data set:   Broman1     a.k.a. Broman_2006
Excel file:   ._Data_Description_B6xC3_Broman2006.xlsx
Excel file:   Data_Description_B6xC3_Broman2006.xlsx
CSV file:   Broman2006_B6xC3_B37_Data.csv
Readme / text file:   ._readme.txt
Readme / text file:   readme_Broman2006.txt
QC plots, figures, etc.:   QCReport_Broman2006.pdf