MPD: Data set: Wang1

Wang1: Plasma HDL cholesterol and atherosclerosis susceptibility in progeny from advanced intercross lines (AILs) involving C57BL/6J and NZB/BlNJ (2003)

Wang X, Le Roy I, Nicodeme E, Li R, Wagner R, Petros C, Churchill GA, Harris S, Darvasi A, Kirilovsky J, Roubertoux PL, Paigen B. Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci. Genome Res. 2003 Jul;13(7):1654-64. Epub 2003 Jun 12. PubMed 12805272

An advanced intercross between C57BL/6J and NZB/BlNJ inbred mouse strains was generated to identify quantitative trait loci (QTL) involved in plasma HDL cholesterol concentrations and susceptibility to atherosclerosis. Blood lipids were measured in F11 mice administered a high-fat (15%) diet from 4-10 wks of age. Plasma was obtained from fasted mice (4 hr). For detailed protocols see Wang et al., 2003.

Note on studied population: C57BL/6J and NZB/BlNJ advanced intercross lines

Procedures conducted:

• study archive

Lipids (plasma). Cholesterol, inducibility, triglycerides, atherosclerosis lesions.

Wang1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Wang1 measures:

MA:0000062 aorta
MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000181 abnormal circulating LDL cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0005340 altered susceptibility to atherosclerosis
MP:0020098 abnormal susceptibility to diet-induced aortic fatty streak lesions
VT:0000180 blood cholesterol amount
VT:0000181 blood LDL cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0000272 aorta morphology trait

Investigators	X Wang Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Le Roy I, Nicodeme E, Li R, Wagner R, Petros C, Harris S, Darvasi A, Kirilovsky J, Roubertoux PL, Paigen B
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Grant: This work was funded by GlaxoSmithKline, France, by the Centre National de la Recherche Scientifique (CNRS) and Ministere de la Recherche et de la Technology of France, and by the Program for Genomic Applications of the Heart, Lung and Blood Institute, National Institutes of Health (HL66611).
Project type	QTL Archive data set
MPD identifiers	Wang1 MPD:136
Data changelog	No updates/corrections. Initial release date: 01/2008.

QTL data set parameters:

Cross 1: B6 x NZB intercross Wang1
Progenitor strains	C57BL/6J NZB/BlNJ
Cross direction notation	(B6 x NZB) x (B6 x NZB)
Cross type	Advanced intercross
Population size	345 ♀ 0 ♂
Notes	F11 progeny

Progenitor strains	C57BL/6J NZB/BlNJ
Cross type	None
Population size	None ♀ None ♂

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Wang1	lipid profile	(none)	HDL cholesterol (plasma) [mg/dL] HDL_chow 13601	QTL population	f	10wks	N=345

Wang1	lipid profile	high-fat diet	HDL cholesterol (plasma) [mg/dL] HDL_fat 13602	QTL population	f	10wks	N=345

Wang1	lipid profile	high-fat diet	HDL inducibility, fold change [fold] HDL_change 13603	QTL population	f	10wks	N=345

Wang1	lipid profile	high-fat diet	HDL inducibility, percent change [%] HDL_inducibility 13604	QTL population	f	10wks	N=345

Wang1	lipid profile	(none)	HDL cholesterol (plasma) [mg/dL] HDL_chow_b 13701	QTL population	f	8wks	N=100

Wang1	lipid profile	high-fat diet	HDL cholesterol (plasma) [mg/dL] HDL_fat4 13702	QTL population	f	12wks	N=100

Wang1	lipid profile	high-fat diet	HDL inducibility, fold change [fold] HDL_change4 13703	QTL population	f	12wks	N=100

Wang1	lipid profile	high-fat diet	HDL inducibility, percent change [%] HDL_inducibility4 13704	QTL population	f	12wks	N=100

Wang1	lipid profile	high-fat diet	HDL cholesterol (plasma) [mg/dL] HDL_fat15 13705	QTL population	f	23wks	N=100

Wang1	lipid profile	high-fat diet	HDL inducibility, fold change [fold] HDL_change15 13706	QTL population	f	23wks	N=100

Wang1	lipid profile	high-fat diet	HDL inducibility, percent change [%] HDL_inducibility15 13707	QTL population	f	23wks	N=100

Wang1	lipid profile	(none)	nonHDL cholesterol (plasma) [mg/dL] nonDHL_chow 13708	QTL population	f	8wks	N=100

Wang1	lipid profile	high-fat diet	nonHDL cholesterol (plasma) [mg/dL] nonHDL_fat4 13709	QTL population	f	12wks	N=100

Wang1	lipid profile	high-fat diet	nonHDL cholesterol (plasma) [mg/dL] nonHDL_fat15 13710	QTL population	f	23wks	N=100

Wang1	lipid profile	(none)	total cholesterol (plasma) [mg/dL] chol_chow 13711	QTL population	f	8wks	N=100

Wang1	lipid profile	high-fat diet	total cholesterol (plasma) [mg/dL] chol_fat4 13712	QTL population	f	12wks	N=100

Wang1	lipid profile	high-fat diet	total cholesterol (plasma) [mg/dL] chol_fat15 13713	QTL population	f	23wks	N=100

Wang1	lipid profile	(none)	HDL:nonHDL ratio [ratio] HDL_nonHDL_chow 13714	QTL population	f	8wks	N=100

Wang1	lipid profile	high-fat diet	HDL:nonHDL ratio [ratio] HDL_nonHDL_fat4 13715	QTL population	f	12wks	N=100

Wang1	lipid profile	high-fat diet	HDL:nonHDL ratio [ratio] HDL_nonHDL_fat15 13716	QTL population	f	23wks	N=100

Wang1	histopathology	high-fat diet	fatty streak aortic lesion size [µm²] aortic_lesion 13717	QTL population	f	23wks	N=100

To see more rows use the paging control at top.

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Hdlq5 Hdlq6 Hdlq7 Hdlq9

Cross 1: B6 x NZB intercross Wang1 a.k.a. Wang_2003a
Excel file: Data_Description_B6xNZB_AIL_Wang2003a.xlsx
CSV file: Wang2003a_B6xNZB_AIL_B37_Data.csv
Readme / text file: readme_Wang2003a.txt

Project / data set: Wang1b a.k.a. None

QTL file list not available on this MPD instance.