Wang1: Plasma HDL cholesterol and atherosclerosis susceptibility in progeny from advanced intercross lines (AILs) involving C57BL/6J and NZB/BlNJ (2003)

Wang X, Le Roy I, Nicodeme E, Li R, Wagner R, Petros C, Churchill GA, Harris S, Darvasi A, Kirilovsky J, Roubertoux PL, Paigen B. Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci. Genome Res. 2003 Jul;13(7):1654-64. Epub 2003 Jun 12.   PubMed 12805272  


       
Wang1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants X Wang
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
With: Le Roy I, Nicodeme E, Li R, Wagner R, Petros C, Harris S, Darvasi A, Kirilovsky J, Roubertoux PL, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsGrant: This work was funded by GlaxoSmithKline, France, by the Centre National de la Recherche Scientifique (CNRS) and Ministere de la Recherche et de la Technology of France, and by the Program for Genomic Applications of the Heart, Lung and Blood Institute, National Institutes of Health (HL66611).
Project type QTL Archive data set
MPD identifiersWang1     MPD:136
Data changelog No updates/corrections.       Initial release date: 01/2008.
An advanced intercross between C57BL/6J and NZB/BlNJ inbred mouse strains was generated to identify quantitative trait loci (QTL) involved in plasma HDL cholesterol concentrations and susceptibility to atherosclerosis. Blood lipids were measured in F11 mice administered a high-fat (15%) diet from 4-10 wks of age. Plasma was obtained from fasted mice (4 hr). For detailed protocols see Wang et al., 2003.


QTL data set parameters:
Cross 1: B6 x NZB intercross       Wang1
Progenitor strains C57BL/6J     NZB/BlNJ    
Cross direction notation(B6 x NZB) x (B6 x NZB)
Cross typeAdvanced intercross
Population size 345 ♀     0 ♂
NotesF11 progeny

Cross 2: B6 x NZB backcross       Wang1b
Progenitor strains C57BL/6J     NZB/BlNJ    
Cross direction notation(B6 x NZB) x (B6 x NZB)
Cross typeBackcross
Population size 100 ♀     0 ♂
NotesF11 progeny


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Hdlq5   Hdlq6   Hdlq7   Hdlq9  


Cross 1: B6 x NZB intercross     Wang1     a.k.a. Wang_2003a
Excel file:   Data_Description_B6xNZB_AIL_Wang2003a.xlsx
CSV file:   Wang2003a_B6xNZB_AIL_B37_Data.csv
Readme / text file:   readme_Wang2003a.txt

Cross 2: B6 x NZB backcross     Wang1b     a.k.a. Wang_2003b
Excel file:   Data_Description_B6xNZB_BC_Wang2003b.xlsx
CSV file:   Wang2003b_B6xNZB_BC_B37_Data.csv
Readme / text file:   readme_Wang2003b.txt