MPD: Phenotype measures mapped to MP:0005319, abnormal enzyme/coenzyme level

Phenotype measures associated with ontology term
MP:0005319 'abnormal enzyme/coenzyme level'

All measures in this list are mapped to the ontology descendants of MP:0005319. None are mapped to MP:0005319 directly.

MP:0000202 abnormal circulating alkaline phosphatase level
MP:0000203 abnormal circulating aspartate transaminase level
MP:0001573 abnormal circulating alanine transaminase level
MP:0002943 abnormal lactate dehydrogenase level
MP:0008804 abnormal circulating amylase level
MP:0010089 abnormal circulating creatine kinase level
MP:0011008 abnormal circulating glutamate dehydrogenase level
MP:0020279 abnormal creatine kinase level

This MP term has been mapped to these MPD phenotype measurements to help users find relevant data. It should be noted that MPD measurements typically have a mixture of high-end, low-end and "normal" readings.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Auwerx1:161	Auwerx1	metabolic panel	high-fat diet	blood alanine transaminase amount [U/L] ala_trans 111340 CD HFD	BXD w/par	54	m	29wks	N=4	2016

Auwerx1:163	Auwerx1	metabolic panel	high-fat diet	blood alkaline phosphatase amount [U/L] alk_phosph 111342 CD HFD	BXD w/par	54	m	29wks	N=4	2016

Auwerx1:165	Auwerx1	metabolic panel	high-fat diet	blood amylase amount [U/L] amylase 111344 CD HFD	BXD w/par	54	m	29wks	N=4	2016

Auwerx1:167	Auwerx1	metabolic panel	high-fat diet	blood aspartate transaminase amount [U/L] asp_trans 111346 CD HFD	BXD w/par	54	m	29wks	N=4	2016

Auwerx1:171	Auwerx1	metabolic panel	high-fat diet	blood creatine kinase amount [U/L] creatine_kin 111350 CD HFD	BXD w/par	54	m	29wks	N=4	2016

Auwerx1:185	Auwerx1	metabolic panel	high-fat diet	blood lactate dehydrogenase (LDH) amount [U/L] ldh 111364 CD HFD	BXD w/par	54	m	29wks	N=4	2016

Auwerx2:143	Auwerx2	metabolic panel	(none)	plasma alanine transaminase amount (ALAT) [U/L] ALAT 114671 CD HFD	inbred w/CC8	9	both	21wks	N=4	2021

Auwerx2:145	Auwerx2	metabolic panel	(none)	plasma aspartate transaminase amount (ASAT) [U/L] ASAT 114673 CD HFD	inbred w/CC8	9	both	21wks	N=4	2021

Auwerx2:151	Auwerx2	metabolic panel	(none)	plasma lactate dehydrogenase amount (LDH) [U/L] LDH 114679 CD HFD	inbred w/CC8	9	both	21wks	N=4	2021

Bennett4:39	Bennett4	metabolic panel	various diets 2	plasma alanine aminotransferase (ALT) amount, baseline [U/L] ALT_base 114733 diet: HP group HFHS group	CC	22	f	8-11wks	N=5	2021

Bennett4:41	Bennett4	metabolic panel	various diets 2	plasma alanine aminotransferase (ALT) amount, post-diet [U/L] ALT_post 114735 diet: HP group HFHS group	CC	22	f	17-20wks	N=4	2021

Bennett4:43	Bennett4	metabolic panel	various diets 2	plasma aspartate aminotransferase (AST) amount, baseline [U/L] AST_base 114737 diet: HP group HFHS group	CC	22	f	8-11wks	N=5	2021

Bennett4:45	Bennett4	metabolic panel	various diets 2	plasma aspartate aminotransferase (AST) amount, post-diet [U/L] AST_post 114739 diet: HP group HFHS group	CC	22	f	17-20wks	N=4	2021

Donahue9:8	Donahue9	metabolic panel	(none)	alkaline phosphatase (serum ALP) [IU/L] ALP 41808	B6.PWD consomic w/par	25	both	11wks	N=8	2011

Donahue9:9	Donahue9	metabolic panel	(none)	alanine transaminase (serum ALT) [IU/L] ALT 41809	B6.PWD consomic w/par	25	both	11wks	N=8	2011

Donahue9:10	Donahue9	metabolic panel	(none)	aspartate transaminase (serum AST) [IU/L] AST 41810	B6.PWD consomic w/par	25	both	11wks	N=8	2011

Donahue9:12	Donahue9	metabolic panel	(none)	lactate dehydrogenase (serum LDH) [U/L] LDH 41812	B6.PWD consomic w/par	25	both	11wks	N=8	2011

Eumorphia1:1	Eumorphia1	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] ALT 23901	inbred	4	both	12wks	N=20	2007

Eumorphia1:2	Eumorphia1	metabolic panel	(none)	alkaline phosphatase (plasma ALP) [IU/L] ALP 23902	inbred	4	both	12wks	N=30	2007

Eumorphia1:3	Eumorphia1	metabolic panel	(none)	aspartate transaminase (plasma AST) [IU/L] AST 23903	inbred	4	both	12wks	N=20	2007

Eumorphia1:4	Eumorphia1	metabolic panel	(none)	creatine kinase (plasma CK) [IU/L] CK 23904	inbred	4	both	12wks	N=34	2007

Eumorphia1:9	Eumorphia1	metabolic panel	(none)	lactate dehydrogenase (plasma LDH) [IU/L] LDH 23909	inbred	4	both	12wks	N=20	2007

Eumorphia1:18	Eumorphia1	metabolic panel	(none)	plasma alpha-amylase [IU/L] amylase 23918	inbred	4	both	12wks	N=33	2007

GMC16:26	GMC16	metabolic panel	(none)	alkaline phosphatase (plasma ALP) [IU/L] ALP 56526 age 16-17wks 20-21wks	inbred w/CC8	8	both		N=7	2018

GMC16:28	GMC16	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] ALT 56528 age 16-17wks 20-21wks	inbred w/CC8	8	both		N=7	2018

GMC16:30	GMC16	metabolic panel	(none)	aspartate transaminase (plasma AST) [IU/L] AST 56530 age 16-17wks 20-21wks	inbred w/CC8	8	both		N=6	2018

GMC16:32	GMC16	metabolic panel	(none)	lactic acid dehydrogenase (plasma LDH) [IU/L] LDH 56532 age 16-17wks 20-21wks	inbred w/CC8	8	both		N=6	2018

GMC16:34	GMC16	metabolic panel	(none)	alpha-amylase (plasma) [IU/L] amylase 56534 age 16-17wks 20-21wks	inbred w/CC8	8	both		N=7	2018

Harrill1:21	Harrill1	metabolic panel	isoniazid	alanine transaminase (serum ALT) [IU/L] ALT 39521 control isoniazid	inbred	34	f	8-10wks	N=4	2011

Harrill2:11	Harrill2	metabolic panel	DB289	alanine transaminase (serum ALT) [IU/L] ALT 44111 control DB289 difference	inbred	34	f	6-8wks	N=5	2012

JaxCC1:9185	JaxCC1	metabolic panel	(none)	alkaline phosphatase (plasma ALP) [IU/L] ALP 89185	CC	18	both	17-19wks	N=6	2017

JaxCC1:9187	JaxCC1	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] ALT 89187	CC	18	both	17-19wks	N=6	2017

JaxCC1:9188	JaxCC1	metabolic panel	(none)	aspartate transaminase (plasma AST) [IU/L] AST 89188	CC	18	both	17-19wks	N=6	2017

JaxCC1:9189	JaxCC1	metabolic panel	(none)	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT) [ratio] AST_ALT_ratio 89189	CC	18	both	17-19wks	N=6	2017

JaxKOMP-EAP:378	JaxKOMP-EAP	metabolic panel	(none)	alkaline phosphatase (plasma ALP) [IU/L] ALP alkaline_phosphatase 100152 IMPC_CBC_014_001	KOMP	1768	both	17wks	N=6	2021

JaxKOMP-EAP:392	JaxKOMP-EAP	metabolic panel	(none)	aspartate transaminase (plasma AST) [IU/L] AST aspartate_aminotransferase_ast 100166 IMPC_CBC_012_001	KOMP	1767	both	17wks	N=6	2021

JaxKOMP-EAP:395	JaxKOMP-EAP	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] ALT alanine_aminotransferase_alt 100169 IMPC_CBC_013_001	KOMP	1768	both	17wks	N=6	2021

JaxKOMP-EAP:396	JaxKOMP-EAP	metabolic panel	(none)	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT) [ratio] AST_ALT_ratio ast_alt_ratio 100170 IMPC_CBC_013_001	KOMP	1765	both	17wks	N=6	2021

JaxKOMP-LAP:290	JaxKOMP-LAP	metabolic panel	(none)	alkaline phosphatase (plasma ALP) [IU/L] ALP alkaline_phosphatase 101152 IMPC_CBC_014_001	KOMP	101	both	75-81wks	N=6	2021

JaxKOMP-LAP:304	JaxKOMP-LAP	metabolic panel	(none)	aspartate transaminase (plasma AST) [IU/L] AST aspartate_aminotransferase_ast 101166 IMPC_CBC_012_001	KOMP	100	both	75-81wks	N=6	2021

JaxKOMP-LAP:307	JaxKOMP-LAP	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] ALT alanine_aminotransferase_alt 101169 IMPC_CBC_013_001	KOMP	99	both	75-81wks	N=6	2021

JaxKOMP-LAP:308	JaxKOMP-LAP	metabolic panel	(none)	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT) [ratio] AST_ALT_ratio ast_alt_ratio 101170 IMPC_CBC_013_001	KOMP	100	both	75-81wks	N=6	2021

Jaxpheno3:15	Jaxpheno3	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] ALT 22815 age 8wks age 16wks	inbred	11	both		N=16	2006

Jaxpheno3:17	Jaxpheno3	metabolic panel	(none)	creatine kinase (plasma CK) [IU/L] CK 22817 age 8wks age 16wks	inbred	11	both		N=16	2006

Lake1:29	Lake1	metabolic panel	(none)	aspartate transaminase (plasma AST) [mg/dL] AST 19929	B6.A consomic w/par	23	both	8wks	N=7	2005

Paigen1:24	Paigen1	metabolic panel	high-fat diet	alanine transaminase (plasma ALT) [IU/L] ALT 2924	inbred	43	both	15-19wks	N=8	2000

Paigen3:24	Paigen3	metabolic panel	high-fat diet	alanine transaminase (plasma ALT) [IU/L] ALT 2824	obesity mutants	8	both	15-19wks	N=16	2000

RIKEN-EAD1:4	RIKEN-EAD1	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] ALT 37204	inbred RBRC	37	both	8wks	N=10	2008

RIKEN-EAD1:5	RIKEN-EAD1	metabolic panel	(none)	aspartate transaminase (plasma AST) [IU/L] AST 37205	inbred RBRC	37	both	8wks	N=10	2008

RIKEN-EAD1:6	RIKEN-EAD1	metabolic panel	(none)	lactate dehydrogenase (plasma LDH) [IU/L] LDH 37206	inbred RBRC	37	both	8wks	N=10	2008

RIKEN-EAD1:7	RIKEN-EAD1	metabolic panel	(none)	plasma amylase [U/L] amylase 37207	inbred RBRC	37	both	8wks	N=10	2008

RIKEN-EAD1:29	RIKEN-EAD1	metabolic panel	(none)	alkaline phosphatase (plasma ALP) [IU/L] ALP 37229	inbred RBRC	37	both	8wks	N=10	2008

RIKEN-EAD2:4	RIKEN-EAD2	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] ALT 37804	wild-derived RBRC	27	both	8wks	N=12	2008

RIKEN-EAD2:5	RIKEN-EAD2	metabolic panel	(none)	aspartate transaminase (plasma AST) [IU/L] AST 37805	wild-derived RBRC	27	both	8wks	N=12	2008

RIKEN-EAD2:6	RIKEN-EAD2	metabolic panel	(none)	lactate dehydrogenase (plasma LDH) [IU/L] LDH 37806	wild-derived RBRC	27	both	8wks	N=12	2008

RIKEN-EAD2:7	RIKEN-EAD2	metabolic panel	(none)	plasma amylase [U/L] amylase 37807	wild-derived RBRC	27	both	8wks	N=12	2008

RIKEN-EAD2:29	RIKEN-EAD2	metabolic panel	(none)	alkaline phosphatase (plasma ALP) [IU/L] ALP 37829	wild-derived RBRC	27	both	8wks	N=12	2008

Rusyn2:11	Rusyn2	metabolic panel	(none)	alanine transaminase (serum ALT), naive [IU/L] ALT 36111	inbred	16	m	7wks	N=3	2010

Rusyn2:12	Rusyn2	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), control group [IU/L] ALT_ctrl 36112 time: 2h 8h 24h	inbred	17	m	7wks	N=3	2010

Rusyn2:17	Rusyn2	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), treated group [IU/L] ALT_tce 36117 time: 2h 8h 24h	inbred	17	m	7wks	N=3	2010

Rusyn2:21	Rusyn2	metabolic panel	(none)	aspartate transaminase (serum AST), naive [IU/L] AST 36121	inbred	15	m	7wks	N=3	2010

Rusyn2:22	Rusyn2	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), control group [IU/L] AST_ctrl 36122 time: 2h 8h 24h	inbred	16	m	7wks	N=3	2010

Rusyn2:27	Rusyn2	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), treated group [IU/L] AST_tce 36127 time: 2h 8h 24h	inbred	16	m	7wks	N=3	2010

Rusyn5:1	Rusyn5	metabolic panel	high-fat diet and ethanol	serum alanine transaminase (ALT) [IU/L] ALT 43001 high-fat only high-fat and ethanol	inbred	14	m	8-14wks	N=3	2011

Shockley1:4	Shockley1	metabolic panel	high-fat diet	glutamate dehydrogenase (GLDH) [IU/L] GLDH 33404 control diet high-fat diet difference	inbred	10	both	10-13wks	N=5	2008

Svenson3:67	Svenson3	metabolic panel	(none)	aspartate transaminase (plasma AST) [mg/dL] AST 27367	B6.PWD consomic w/par	21	both	8wks	N=7	2006

Svenson7:83	Svenson7	metabolic panel	(none)	glutamate dehydrogenase (plasma GLDH), 4h fast, at 8 wks of age [U/L] gldh_8wks 121328 chow hfhs	DO population		both	8wks	N=172	2020

Svenson7:85	Svenson7	metabolic panel	(none)	glutamate dehydrogenase (plasma GLDH), 4h fast, at 19 wks of age [U/L] gldh_19wks 121330 chow hfhs	DO population		both	19wks	N=192	2020

Threadgill1:6	Threadgill1	metabolic panel	acetaminophen	alanine transaminase (serum ALT) [IU/L] ALT_ctrl 19406	inbred w/CC7	37	m	8-17wks	N=2	2005

Threadgill1:7	Threadgill1	metabolic panel	acetaminophen	alanine transaminase (serum ALT), t=4h [IU/L] ALT_Rx100_4h 19407	inbred w/CC7	7	m	8-17wks	N=4	2005

Threadgill1:8	Threadgill1	metabolic panel	acetaminophen	alanine transaminase (serum ALT), t=12h [IU/L] ALT_Rx100_12h 19408	inbred w/CC7	7	m	8-17wks	N=4	2005

Threadgill1:9	Threadgill1	metabolic panel	acetaminophen	alanine transaminase (serum ALT), t=24h [IU/L] ALT_Rx100_24h 19409	inbred w/CC7	7	m	8-17wks	N=3	2005

Threadgill1:10	Threadgill1	metabolic panel	acetaminophen	aspartate transaminase (serum AST) [IU/L] AST 19410 dose (mg/kg): control 100 200 300	inbred w/CC7	37	m	8-17wks	N=2	2005

Threadgill2:2	Threadgill2	metabolic panel	acetaminophen	alanine transaminase (serum ALT) [IU/L] ALT 39602 50 mg/kg 300 mg/kg	inbred	5	m	6-8wks	N=5	2005

Yuan3:1	Yuan3	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] ALT 24401 6mo 12mo 18mo	inbred	32	both		N=6	2008

Yuan3:11	Yuan3	metabolic panel	(none)	alkaline phosphatase (serum ALP) [IU/L] ALP 24411 6mo 12mo 18mo	inbred	32	both		N=7	2008

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