Project measure / variable:   Threadgill1   ALT_ctrl

ID, description, units MPD:19406   ALT_ctrl   alanine transaminase (serum ALT)   [IU/L]  
acetaminophen study
Data set, strains Threadgill1   inbred w/CC7   37 strains     sex: m     age: 8-17wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Threadgill1 - alanine transaminase (serum ALT)



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested37 strains
Mean of the strain means67.0   IU/L
Median of the strain means42.5   IU/L
SD of the strain means± 81.7
Coefficient of variation (CV)1.22
Min–max range of strain means24.0   –   503   IU/L
Mean sample size per strain2.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 33 469669.52 14232.4097 1.1209 0.3664
Residuals 37 469809.9167 12697.5653


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ m 28.7 4.73   3 2.73 0.165 25.0, 34.0 -0.47
A/J m 49.5 17.7   2   12.5 0.357 37.0, 62.0 -0.21
AKR/J m 29.0 9.9   2   7.0 0.341 22.0, 36.0 -0.47
B6C3F1/J m 32.8 5.8   4 2.9 0.177 25.0, 39.0 -0.42
BALB/cByJ m 83.0 2.83   2   2.0 0.0341 81.0, 85.0 0.2
BTBR T+ Itpr3tf/J m 35.0 7.07   2   5.0 0.202 30.0, 40.0 -0.39
BUB/BnJ m 56.5 0.707   2   0.5 0.0125 56.0, 57.0 -0.13
C3H/HeJ m 92.0 96.2   2   68.0 1.05 24.0, 160.0 0.31
C57BL/10J m 49.0 12.7   2   9.0 0.26 40.0, 58.0 -0.22
C57BL/6J m 36.5 2.12   2   1.5 0.0581 35.0, 38.0 -0.37
C57BLKS/J m 35.0 4.24   2   3.0 0.121 32.0, 38.0 -0.39
C57BR/cdJ m 53.0 1.41   2   1.0 0.0267 52.0, 54.0 -0.17
C57L/J m 70.5 21.9   2   15.5 0.311 55.0, 86.0 0.04
CAST/EiJ m 73.0 0.0   1   0.0 0.0 73.0, 73.0 0.07
CBA/J m 32.5 2.12   2   1.5 0.0653 31.0, 34.0 -0.42
CZECHII/EiJ m 24.0 12.7   2   9.0 0.53 15.0, 33.0 -0.53
DBA/2J m 65.0 8.49   2   6.0 0.131 59.0, 71.0 -0.02
FVB/NJ m 59.5 12.0   2   8.5 0.202 51.0, 68.0 -0.09
JF1/MsJ m 32.5 0.707   2   0.5 0.0218 32.0, 33.0 -0.42
KK/HlJ m 72.5 51.6   2   36.5 0.712 36.0, 109.0 0.07
LP/J m 29.0 7.07   2   5.0 0.244 24.0, 34.0 -0.47
MA/MyJ m 144.0 135.0   2   95.5 0.935 49.0, 240.0 0.94
MSM/MsJ m 58.0 2.83   2   2.0 0.0488 56.0, 60.0 -0.11
NOD/ShiLtJ m 37.0 2.83   2   2.0 0.0764 35.0, 39.0 -0.37
NON/ShiLtJ m 25.5 4.95   2   3.5 0.194 22.0, 29.0 -0.51
NZO/HlLtJ m 31.0 5.66   2   4.0 0.182 27.0, 35.0 -0.44
NZW/LacJ m 30.0 9.9   2   7.0 0.33 23.0, 37.0 -0.45
PERA/EiJ m 144.0 0.0   1   0.0 0.0 144.0, 144.0 0.94
P/J m 503.0 659.0   2   466.0 1.31 37.0, 969.0 5.33
PL/J m 48.0 17.0   2   12.0 0.354 36.0, 60.0 -0.23
PWD/PhJ m 81.0 48.1   2   34.0 0.594 47.0, 115.0 0.17
RIIIS/J m 24.5 6.36   2   4.5 0.26 20.0, 29.0 -0.52
SEA/GnJ m 30.0 0.0   1   0.0 0.0 30.0, 30.0 -0.45
SJL/J m 42.5 2.12   2   1.5 0.0499 41.0, 44.0 -0.3
SM/J m 31.5 3.54   2   2.5 0.112 29.0, 34.0 -0.43
SWR/J m 36.0 1.41   2   1.0 0.0393 35.0, 37.0 -0.38
WSB/EiJ m 176.0 28.3   2   20.0 0.161 156.0, 196.0 1.33


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 28.6667 65.0578 160.4864 0.0
A/J m 49.5 79.6792 210.9455 0.0
AKR/J m 29.0 79.6792 190.4455 0.0
B6C3F1/J m 32.75 56.3417 146.9092 0.0
BALB/cByJ m 83.0 79.6792 244.4455 0.0
BTBR T+ Itpr3tf/J m 35.0 79.6792 196.4455 0.0
BUB/BnJ m 56.5 79.6792 217.9455 0.0
C3H/HeJ m 92.0 79.6792 253.4455 0.0
C57BL/10J m 49.0 79.6792 210.4455 0.0
C57BL/6J m 36.5 79.6792 197.9455 0.0
C57BLKS/J m 35.0 79.6792 196.4455 0.0
C57BR/cdJ m 53.0 79.6792 214.4455 0.0
C57L/J m 70.5 79.6792 231.9455 0.0
CBA/J m 32.5 79.6792 193.9455 0.0
CZECHII/EiJ m 24.0 79.6792 185.4455 0.0
DBA/2J m 65.0 79.6792 226.4455 0.0
FVB/NJ m 59.5 79.6792 220.9455 0.0
JF1/MsJ m 32.5 79.6792 193.9455 0.0
KK/HlJ m 72.5 79.6792 233.9455 0.0
LP/J m 29.0 79.6792 190.4455 0.0
MA/MyJ m 144.5 79.6792 305.9455 0.0
MSM/MsJ m 58.0 79.6792 219.4455 0.0
NOD/ShiLtJ m 37.0 79.6792 198.4455 0.0
NON/ShiLtJ m 25.5 79.6792 186.9455 0.0
NZO/HlLtJ m 31.0 79.6792 192.4455 0.0
NZW/LacJ m 30.0 79.6792 191.4455 0.0
P/J m 503.0 79.6792 664.4455 341.5545
PL/J m 48.0 79.6792 209.4455 0.0
PWD/PhJ m 81.0 79.6792 242.4455 0.0
RIIIS/J m 24.5 79.6792 185.9455 0.0
SJL/J m 42.5 79.6792 203.9455 0.0
SM/J m 31.5 79.6792 192.9455 0.0
SWR/J m 36.0 79.6792 197.4455 0.0
WSB/EiJ m 176.0 79.6792 337.4455 14.5545




  GWAS USING LINEAR MIXED MODELS