Rusyn2: Effects of trichloroethylene in males of 17 inbred mouse strains (2010)

Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci. 2011 Mar;120(1):206-17. Epub 2010 Dec 6.   PubMed 21135412     FullText


       
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Participants Ivan Rusyn       Texas A&M University College Station, TX
David W Threadgill       Texas A&M University College Station, TX
With: Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Tryndyak V, Pogribny IP, Bleyle L, Koop DR
ContactIvan Rusyn     IRusyn@cvm.tamu.edu     Lab web site
Part of a series: • Phenotype data   (this project) Rusyn2
AcknowledgementsFunding provided by NIH ES005948
Project type Phenotype strain survey data set
MPD identifiersRusyn2     MPD:361
Data changelog No updates/corrections.       Initial release date: 04/2011.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation into the effects of trichloroethylene. There were 3 cohorts: 1) naive mice; 2) control group orally administered vehicle (corn oil); 3) treated group orally administered trichloroethylene (TCE 2100 mg/kg) in vehicle.

Summary of procedures that were conducted
• metabolic panel Blood urea nitrogen, alanine transaminase, aspartate transaminase (serum). Baseline and trichloroethylene-exposed (several timepoints). No fast.
• drug and metabolite quantification Trichloroethylene metabolites in serum, 2h, 4h, 24h after trichoroethylene exposure.
Mice: inbred   17 strains   ♂   age 7wks   3 cohorts