Rusyn2: Effects of trichloroethylene in males of 17 inbred mouse strains (2010)

Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci. 2011 Mar;120(1):206-17. Epub 2010 Dec 6.   PubMed 21135412     FullText


         
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Investigators Ivan Rusyn       Texas A&M University,  College Station, TX
David W Threadgill       Texas A&M University,  College Station, TX
Participants Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Tryndyak V, Pogribny IP, Bleyle L, Koop DR
ContactIvan Rusyn     IRusyn@cvm.tamu.edu     Lab web site
Part of a series: • Phenotype data   (this project) Rusyn2
AcknowledgementsFunding provided by NIH ES005948
Project type Phenotype strain survey data set
MPD identifiersRusyn2     MPD:361
Data changelog No updates/corrections.       Initial release date: 04/2011.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
An investigation into the effects of trichloroethylene. There were 3 cohorts: 1) naive mice; 2) control group orally administered vehicle (corn oil); 3) treated group orally administered trichloroethylene (TCE 2100 mg/kg) in vehicle.

Procedures conducted:
• metabolic panel  Blood urea nitrogen, alanine transaminase, aspartate transaminase (serum). Baseline and trichloroethylene-exposed (several timepoints). No fast.
• drug and metabolite quantification  Trichloroethylene metabolites in serum, 2h, 4h, 24h after trichoroethylene exposure.

Mice: inbred   17 strains   ♂   age 7wks   3 experimental groups

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Procedure / Protocol
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Age
    Rusyn2 body weight (none) body weight, naive (local parameter)   [g]  BW   36101 inbred 14 m 7wks N=3
    Rusyn2 body weight (none) body weight, t=2h (local parameter)   [g]  BW_2_ctrl   36102 inbred 16 m 7wks N=3
    Rusyn2 body weight (none) body weight, t=8h (local parameter)   [g]  BW_8_ctrl   36103 inbred 17 m 7wks N=3
    Rusyn2 body weight (none) body weight, t=24h (local parameter)   [g]  BW_24_ctrl   36104 inbred 16 m 7wks N=3
    Rusyn2 body weight (none) body weight, t=2h (local parameter)   [g]  BW_2_tce   36107 inbred 16 m 7wks N=3
    Rusyn2 body weight (none) body weight, t=8h (local parameter)   [g]  BW_8_tce   36108 inbred 17 m 7wks N=3
    Rusyn2 body weight (none) body weight, t=24h (local parameter)   [g]  BW_24_tce   36109 inbred 16 m 7wks N=3
    Rusyn2 metabolic panel (none) alanine transaminase (serum ALT), naive   [IU/L]  ALT   36111 inbred 16 m 7wks N=3
    Rusyn2 metabolic panel trichloroethylene alanine transaminase (serum ALT), control group   [IU/L]  ALT_ctrl   36112     time: 2h    8h    24h inbred 17 m 7wks N=3
    Rusyn2 metabolic panel trichloroethylene alanine transaminase (serum ALT), treated group   [IU/L]  ALT_tce   36117     time: 2h    8h    24h inbred 17 m 7wks N=3
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