MPD: Project measures / variables set: Rusyn2 AST

Project measures / variables set: Rusyn2 AST_tce

ID, description, units	MPD:36127 AST_tce aspartate transaminase (serum AST), treated group [IU/L] trichloroethylene study
Measures	• time: 2h • 8h • 24h
Data set, strains	Rusyn2 inbred 16 strains sex: m age: 7wks
Procedure	metabolic panel
Comparison	timecourse but different cohorts
Ontology mappings	VT:0000203 blood aspartate transaminase amount VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0000203 abnormal circulating aspartate transaminase level MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Rusyn2 - aspartate transaminase (serum AST), treated group

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
time	2	1352.5587	676.2793	0.0539	0.9475
strain	14	250492.3372	17892.3098	1.4271	0.1574
time:strain	28	431746.4972	15419.5178	1.2299	0.2305
Residuals	89	1115836.6667	12537.4906

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Rusyn2	36127	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), treated group [IU/L] 2h after treatment AST_2_tce	inbred	15	m	7wks
Rusyn2	36128	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), treated group [IU/L] 8h after treatment AST_8_tce	inbred	16	m	7wks
Rusyn2	36129	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), treated group [IU/L] 24h after treatment AST_24_tce	inbred	15	m	7wks