Project measure / variable:   Donahue9   AST

ID, description, units MPD:41810   AST   aspartate transaminase (serum AST)   [IU/L]  
Data set, strains Donahue9   B6.PWD consomic w/par   25 strains     sex: both     age: 11wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Donahue9 - aspartate transaminase (serum AST)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested23 strains25 strains
Mean of the strain means313   IU/L 283   IU/L
Median of the strain means314   IU/L 271   IU/L
SD of the strain means± 76.0 ± 69.4
Coefficient of variation (CV)0.243 0.245
Min–max range of strain means178   –   495   IU/L 198   –   526   IU/L
Mean sample size per strain7.5   mice 7.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 96671.6925 96671.6925 11.9373 0.0006
strain 22 1209866.119 54993.9145 6.7908 < 0.0001
sex:strain 22 256763.929 11671.0877 1.4412 0.0932
Residuals 307 2486180.996 8098.3094


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6.PWD-Chr1 f 314.0 78.5   7 29.7 0.25 209.0, 441.0 0.01
B6.PWD-Chr1 m 317.0 96.3   8 34.0 0.304 145.0, 479.0 0.48
B6.PWD-Chr10.1 f 412.0 62.1   6 25.4 0.151 361.0, 508.0 1.3
B6.PWD-Chr10.1 m 311.0 49.4   8 17.5 0.159 246.0, 372.0 0.4
B6.PWD-Chr10.2 f 379.0 101.0   10 31.8 0.266 225.0, 563.0 0.86
B6.PWD-Chr10.2 m 289.0 86.9   10 27.5 0.301 199.0, 428.0 0.08
B6.PWD-Chr10.3 f 418.0 166.0   6 67.7 0.397 278.0, 708.0 1.38
B6.PWD-Chr10.3 m 311.0 61.7   8 21.8 0.198 231.0, 397.0 0.4
B6.PWD-Chr11.1 f 355.0 81.2   12 23.4 0.229 222.0, 515.0 0.55
B6.PWD-Chr11.1 m 285.0 59.6   12 17.2 0.209 190.0, 377.0 0.02
B6.PWD-Chr11.2 f 329.0 162.0   9 53.9 0.491 198.0, 722.0 0.21
B6.PWD-Chr11.2 m 325.0 127.0   9 42.4 0.391 118.0, 545.0 0.6
B6.PWD-Chr11.3 f 263.0 44.0   9 14.7 0.167 196.0, 317.0 -0.66
B6.PWD-Chr11.3 m 254.0 59.9   8 21.2 0.236 179.0, 349.0 -0.42
B6.PWD-Chr12 f 198.0 56.0   8 19.8 0.283 102.0, 270.0 -1.52
B6.PWD-Chr12 m 222.0 78.7   8 27.8 0.355 118.0, 359.0 -0.89
B6.PWD-Chr14 f 258.0 70.4   7 26.6 0.272 177.0, 354.0 -0.73
B6.PWD-Chr14 m 214.0 52.8   8 18.7 0.247 161.0, 317.0 -1.0
B6.PWD-Chr15 f 258.0 62.5   8 22.1 0.242 196.0, 365.0 -0.73
B6.PWD-Chr15 m 249.0 62.6   8 22.1 0.252 165.0, 333.0 -0.5
B6.PWD-Chr16 f 371.0 148.0   10 46.9 0.4 190.0, 615.0 0.76
B6.PWD-Chr16 m 271.0 79.3   5 35.5 0.292 159.0, 343.0 -0.18
B6.PWD-Chr17 f 282.0 90.6   8 32.0 0.321 192.0, 434.0 -0.41
B6.PWD-Chr17 m 198.0 60.5   8 21.4 0.305 126.0, 292.0 -1.23
B6.PWD-Chr18 f 332.0 96.7   8 34.2 0.291 209.0, 476.0 0.25
B6.PWD-Chr18 m 255.0 47.1   8 16.7 0.185 188.0, 329.0 -0.41
B6.PWD-Chr19 f 287.0 99.4   8 35.2 0.346 144.0, 481.0 -0.35
B6.PWD-Chr19 m 362.0 153.0   8 53.9 0.421 207.0, 639.0 1.13
B6.PWD-Chr3 m 316.0 119.0   9 39.7 0.376 149.0, 477.0 0.47
B6.PWD-Chr5 f 190.0 91.4   8 32.3 0.482 66.0, 300.0 -1.62
B6.PWD-Chr5 m 220.0 70.7   7 26.7 0.321 127.0, 293.0 -0.91
B6.PWD-Chr6 f 291.0 129.0   7 48.6 0.442 122.0, 456.0 -0.29
B6.PWD-Chr6 m 329.0 83.7   8 29.6 0.254 233.0, 485.0 0.66
B6.PWD-Chr9 f 178.0 40.6   4 20.3 0.228 139.0, 234.0 -1.78
B6.PWD-Chr9 m 228.0 78.9   7 29.8 0.347 133.0, 346.0 -0.8
B6.PWD-ChrX.1 f 270.0 116.0   5 51.9 0.43 169.0, 458.0 -0.57
B6.PWD-ChrX.1 m 245.0 77.7   6 31.7 0.317 163.0, 370.0 -0.55
B6.PWD-ChrX.2 m 235.0 45.6   9 15.2 0.194 155.0, 312.0 -0.7
B6.PWD-ChrX.3 f 321.0 87.5   8 30.9 0.273 211.0, 421.0 0.1
B6.PWD-ChrX.3 m 217.0 38.2   8 13.5 0.176 157.0, 272.0 -0.96
B6.PWD-ChrY f 362.0 119.0   8 41.9 0.328 266.0, 570.0 0.64
B6.PWD-ChrY m 373.0 65.7   8 23.2 0.176 263.0, 461.0 1.29
B6.PWD-mt f 295.0 82.4   8 29.1 0.279 211.0, 427.0 -0.24
B6.PWD-mt m 256.0 49.3   8 17.4 0.192 177.0, 322.0 -0.4
C57BL/6J f 348.0 135.0   4 67.7 0.389 229.0, 536.0 0.46
C57BL/6J m 279.0 41.2   8 14.6 0.147 192.0, 318.0 -0.06
PWD/PhJ f 495.0 82.2   5 36.8 0.166 409.0, 583.0 2.39
PWD/PhJ m 526.0 102.0   4 50.8 0.193 430.0, 629.0 3.49


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 f 313.5714 34.0133 380.5 246.6428
B6.PWD-Chr1 m 317.0 31.8165 379.606 254.394
B6.PWD-Chr10.1 f 411.5 36.7385 483.7912 339.2088
B6.PWD-Chr10.1 m 311.25 31.8165 373.856 248.644
B6.PWD-Chr10.2 f 378.7 28.4575 434.6965 322.7035
B6.PWD-Chr10.2 m 289.0 28.4575 344.9965 233.0035
B6.PWD-Chr10.3 f 418.3333 36.7385 490.6245 346.0422
B6.PWD-Chr10.3 m 311.125 31.8165 373.731 248.519
B6.PWD-Chr11.1 f 354.5833 25.9781 405.7009 303.4658
B6.PWD-Chr11.1 m 284.9167 25.9781 336.0342 233.7991
B6.PWD-Chr11.2 f 329.3333 29.9969 388.3588 270.3079
B6.PWD-Chr11.2 m 325.1111 29.9969 384.1366 266.0856
B6.PWD-Chr11.3 f 262.6667 29.9969 321.6921 203.6412
B6.PWD-Chr11.3 m 254.0 31.8165 316.606 191.394
B6.PWD-Chr12 f 197.5 31.8165 260.106 134.894
B6.PWD-Chr12 m 221.625 31.8165 284.231 159.019
B6.PWD-Chr14 f 258.4286 34.0133 325.3572 191.5
B6.PWD-Chr14 m 213.75 31.8165 276.356 151.144
B6.PWD-Chr15 f 258.5 31.8165 321.106 195.894
B6.PWD-Chr15 m 248.625 31.8165 311.231 186.019
B6.PWD-Chr16 f 371.1 28.4575 427.0965 315.1035
B6.PWD-Chr16 m 271.4 40.245 350.591 192.209
B6.PWD-Chr17 f 282.375 31.8165 344.981 219.769
B6.PWD-Chr17 m 198.25 31.8165 260.856 135.644
B6.PWD-Chr18 f 332.5 31.8165 395.106 269.894
B6.PWD-Chr18 m 254.625 31.8165 317.231 192.019
B6.PWD-Chr19 f 287.125 31.8165 349.731 224.519
B6.PWD-Chr19 m 362.125 31.8165 424.731 299.519
B6.PWD-Chr5 f 189.75 31.8165 252.356 127.144
B6.PWD-Chr5 m 219.8571 34.0133 286.7857 152.9285
B6.PWD-Chr6 f 291.1429 34.0133 358.0715 224.2143
B6.PWD-Chr6 m 329.125 31.8165 391.731 266.519
B6.PWD-Chr9 f 178.5 44.9953 267.0382 89.9618
B6.PWD-Chr9 m 227.5714 34.0133 294.5 160.6428
B6.PWD-ChrX.1 f 270.0 40.245 349.191 190.809
B6.PWD-ChrX.1 m 245.1667 36.7385 317.4578 172.8755
B6.PWD-ChrX.3 f 321.0 31.8165 383.606 258.394
B6.PWD-ChrX.3 m 217.125 31.8165 279.731 154.519
B6.PWD-ChrY f 362.0 31.8165 424.606 299.394
B6.PWD-ChrY m 372.875 31.8165 435.481 310.269
B6.PWD-mt f 295.125 31.8165 357.731 232.519
B6.PWD-mt m 256.375 31.8165 318.981 193.769
C57BL/6J f 348.25 44.9953 436.7882 259.7118
C57BL/6J m 279.25 31.8165 341.856 216.644
PWD/PhJ f 494.8 40.245 573.991 415.609
PWD/PhJ m 526.0 44.9953 614.5382 437.4618


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 both 315.2857 23.2873 361.1086 269.4628
B6.PWD-Chr10.1 both 361.375 24.3002 409.1911 313.5589
B6.PWD-Chr10.2 both 333.85 20.1225 373.4455 294.2545
B6.PWD-Chr10.3 both 364.7292 24.3002 412.5453 316.9131
B6.PWD-Chr11.1 both 319.75 18.3693 355.8956 283.6044
B6.PWD-Chr11.2 both 327.2222 21.211 368.9595 285.4849
B6.PWD-Chr11.3 both 258.3333 21.8638 301.3552 215.3115
B6.PWD-Chr12 both 209.5625 22.4977 253.8316 165.2934
B6.PWD-Chr14 both 236.0893 23.2873 281.9122 190.2664
B6.PWD-Chr15 both 253.5625 22.4977 297.8316 209.2934
B6.PWD-Chr16 both 321.25 24.6449 369.7444 272.7556
B6.PWD-Chr17 both 240.3125 22.4977 284.5816 196.0434
B6.PWD-Chr18 both 293.5625 22.4977 337.8316 249.2934
B6.PWD-Chr19 both 324.625 22.4977 368.8941 280.3559
B6.PWD-Chr5 both 204.8036 23.2873 250.6265 158.9807
B6.PWD-Chr6 both 310.1339 23.2873 355.9568 264.311
B6.PWD-Chr9 both 203.0357 28.2023 258.53 147.5414
B6.PWD-ChrX.1 both 257.5833 27.246 311.1959 203.9708
B6.PWD-ChrX.3 both 269.0625 22.4977 313.3316 224.7934
B6.PWD-ChrY both 367.4375 22.4977 411.7066 323.1684
B6.PWD-mt both 275.75 22.4977 320.0191 231.4809
C57BL/6J both 313.75 27.5539 367.9684 259.5316
PWD/PhJ both 510.4 30.1838 569.7932 451.0068




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA