Project measure / variable:   Lake1   AST

ID, description, units MPD:19929   AST   aspartate transaminase (plasma AST)   [mg/dL]  
Data set, strains Lake1   B6.A consomic w/par   23 strains     sex: both     age: 8wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Lake1 - aspartate transaminase (plasma AST)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested23 strains23 strains
Mean of the strain means78.0   mg/dL 77.3   mg/dL
Median of the strain means73.9   mg/dL 74.8   mg/dL
SD of the strain means± 14.0 ± 13.0
Coefficient of variation (CV)0.180 0.168
Min–max range of strain means57.4   –   110   mg/dL 57.2   –   102   mg/dL
Mean sample size per strain7.3   mice 7.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 13.2757 13.2757 0.026 0.872
strain 22 40699.4473 1849.9749 3.622 < 0.0001
sex:strain 22 17220.5624 782.7528 1.5325 0.0621
Residuals 293 149653.9948 510.7645


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 108.0 14.8   8 5.24 0.138 97.0, 140.0 2.13
A/J m 102.0 41.4   8 14.6 0.408 68.0, 198.0 1.9
B6.A-Chr1 f 74.8 12.7   5 5.68 0.17 56.0, 90.0 -0.23
B6.A-Chr1 m 76.9 14.4   7 5.45 0.188 62.0, 102.0 -0.03
B6.A-Chr10 f 71.2 19.6   8 6.95 0.276 54.0, 113.0 -0.49
B6.A-Chr10 m 82.1 35.0   7 13.2 0.427 44.0, 146.0 0.37
B6.A-Chr11 f 72.5 9.01   8 3.18 0.124 61.0, 82.0 -0.4
B6.A-Chr11 m 86.0 40.0   7 15.1 0.466 54.0, 157.0 0.67
B6.A-Chr12 f 66.9 17.7   8 6.25 0.264 50.0, 106.0 -0.79
B6.A-Chr12 m 68.2 18.7   8 6.62 0.274 46.0, 102.0 -0.7
B6.A-Chr13 f 85.4 29.0   7 11.0 0.34 58.0, 146.0 0.52
B6.A-Chr13 m 89.4 28.5   8 10.1 0.319 55.0, 122.0 0.93
B6.A-Chr14 f 72.2 19.4   8 6.84 0.268 59.0, 117.0 -0.42
B6.A-Chr14 m 57.2 8.07   8 2.85 0.141 46.0, 69.0 -1.55
B6.A-Chr15 f 110.0 51.5   6 21.0 0.47 51.0, 206.0 2.28
B6.A-Chr15 m 73.5 25.2   8 8.9 0.342 51.0, 127.0 -0.29
B6.A-Chr16 f 67.2 9.84   8 3.48 0.146 57.0, 84.0 -0.77
B6.A-Chr16 m 68.8 9.43   6 3.85 0.137 54.0, 83.0 -0.66
B6.A-Chr17 f 99.0 19.6   4 9.81 0.198 79.0, 122.0 1.49
B6.A-Chr17 m 68.1 19.5   8 6.89 0.286 49.0, 113.0 -0.71
B6.A-Chr18 f 84.5 30.3   8 10.7 0.359 52.0, 133.0 0.46
B6.A-Chr18 m 87.6 30.9   8 10.9 0.353 56.0, 160.0 0.79
B6.A-Chr19 f 78.3 26.7   7 10.1 0.341 64.0, 138.0 0.02
B6.A-Chr19 m 72.1 4.74   7 1.79 0.0657 66.0, 78.0 -0.4
B6.A-Chr2 f 85.5 18.1   8 6.38 0.211 63.0, 108.0 0.53
B6.A-Chr2 m 88.0 31.3   5 14.0 0.355 60.0, 139.0 0.82
B6.A-Chr3 f 69.9 12.3   8 4.36 0.176 51.0, 83.0 -0.58
B6.A-Chr3 m 90.0 31.4   8 11.1 0.349 59.0, 155.0 0.97
B6.A-Chr4 f 65.0 5.06   6 2.07 0.0778 60.0, 74.0 -0.93
B6.A-Chr4 m 74.8 26.5   8 9.38 0.355 45.0, 118.0 -0.19
B6.A-Chr5 f 67.6 11.1   8 3.94 0.165 52.0, 90.0 -0.74
B6.A-Chr5 m 62.1 4.58   8 1.62 0.0737 54.0, 70.0 -1.17
B6.A-Chr6 f 89.1 20.0   7 7.58 0.225 63.0, 117.0 0.79
B6.A-Chr6 m 100.0 24.3   8 8.59 0.243 73.0, 134.0 1.74
B6.A-Chr7 f 73.9 11.3   7 4.28 0.153 61.0, 94.0 -0.3
B6.A-Chr7 m 59.1 11.5   7 4.34 0.194 38.0, 73.0 -1.4
B6.A-Chr8 f 57.4 11.0   8 3.88 0.191 43.0, 74.0 -1.47
B6.A-Chr8 m 67.9 13.7   11 4.12 0.201 50.0, 91.0 -0.72
B6.A-Chr9 f 66.5 12.3   6 5.02 0.185 53.0, 81.0 -0.82
B6.A-Chr9 m 66.0 11.3   8 3.99 0.171 53.0, 80.0 -0.87
B6.A-ChrX f 77.9 24.3   7 9.19 0.312 47.0, 112.0 -0.01
B6.A-ChrX m 61.9 17.5   8 6.19 0.283 47.0, 102.0 -1.19
B6.A-ChrY f 61.9 28.7   8 10.2 0.465 38.0, 129.0 -1.15
B6.A-ChrY m 91.2 25.5   6 10.4 0.28 49.0, 113.0 1.07
C57BL/6J f 90.4 26.4   7 9.96 0.291 65.0, 139.0 0.88
C57BL/6J m 85.7 25.0   7 9.43 0.291 60.0, 132.0 0.64


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 107.625 7.9903 123.3507 91.8993
A/J m 101.625 7.9903 117.3507 85.8993
B6.A-Chr1 f 74.8 10.1071 94.6917 54.9083
B6.A-Chr1 m 76.8571 8.542 93.6687 60.0456
B6.A-Chr10 f 71.25 7.9903 86.9757 55.5243
B6.A-Chr10 m 82.1429 8.542 98.9544 65.3313
B6.A-Chr11 f 72.5 7.9903 88.2257 56.7743
B6.A-Chr11 m 86.0 8.542 102.8115 69.1885
B6.A-Chr12 f 66.875 7.9903 82.6007 51.1493
B6.A-Chr12 m 68.25 7.9903 83.9757 52.5243
B6.A-Chr13 f 85.4286 8.542 102.2401 68.617
B6.A-Chr13 m 89.375 7.9903 105.1007 73.6493
B6.A-Chr14 f 72.25 7.9903 87.9757 56.5243
B6.A-Chr14 m 57.25 7.9903 72.9757 41.5243
B6.A-Chr15 f 109.6667 9.2265 127.8252 91.5081
B6.A-Chr15 m 73.5 7.9903 89.2257 57.7743
B6.A-Chr16 f 67.25 7.9903 82.9757 51.5243
B6.A-Chr16 m 68.8333 9.2265 86.9919 50.6748
B6.A-Chr17 f 99.0 11.3 121.2396 76.7604
B6.A-Chr17 m 68.125 7.9903 83.8507 52.3993
B6.A-Chr18 f 84.5 7.9903 100.2257 68.7743
B6.A-Chr18 m 87.625 7.9903 103.3507 71.8993
B6.A-Chr19 f 78.2857 8.542 95.0972 61.4742
B6.A-Chr19 m 72.1429 8.542 88.9544 55.3313
B6.A-Chr2 f 85.5 7.9903 101.2257 69.7743
B6.A-Chr2 m 88.0 10.1071 107.8917 68.1083
B6.A-Chr3 f 69.875 7.9903 85.6007 54.1493
B6.A-Chr3 m 90.0 7.9903 105.7257 74.2743
B6.A-Chr4 f 65.0 9.2265 83.1585 46.8415
B6.A-Chr4 m 74.75 7.9903 90.4757 59.0243
B6.A-Chr5 f 67.625 7.9903 83.3507 51.8993
B6.A-Chr5 m 62.125 7.9903 77.8507 46.3993
B6.A-Chr6 f 89.1429 8.542 105.9544 72.3313
B6.A-Chr6 m 100.0 7.9903 115.7257 84.2743
B6.A-Chr7 f 73.8571 8.542 90.6687 57.0456
B6.A-Chr7 m 59.1429 8.542 75.9544 42.3313
B6.A-Chr8 f 57.375 7.9903 73.1007 41.6493
B6.A-Chr8 m 67.9091 6.8142 81.32 54.4981
B6.A-Chr9 f 66.5 9.2265 84.6585 48.3415
B6.A-Chr9 m 66.0 7.9903 81.7257 50.2743
B6.A-ChrX f 77.8571 8.542 94.6687 61.0456
B6.A-ChrX m 61.875 7.9903 77.6007 46.1493
B6.A-ChrY f 61.875 7.9903 77.6007 46.1493
B6.A-ChrY m 91.1667 9.2265 109.3252 73.0081
C57BL/6J f 90.4286 8.542 107.2401 73.617
C57BL/6J m 85.7143 8.542 102.5258 68.9028


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 104.625 5.65 115.7448 93.5052
B6.A-Chr1 both 75.8286 6.6166 88.8507 62.8064
B6.A-Chr10 both 76.6964 5.8483 88.2065 65.1864
B6.A-Chr11 both 79.25 5.8483 90.7601 67.7399
B6.A-Chr12 both 67.5625 5.65 78.6823 56.4427
B6.A-Chr13 both 87.4018 5.8483 98.9118 75.8917
B6.A-Chr14 both 64.75 5.65 75.8698 53.6302
B6.A-Chr15 both 91.5833 6.1027 103.5941 79.5726
B6.A-Chr16 both 68.0417 6.1027 80.0524 56.0309
B6.A-Chr17 both 83.5625 6.9198 97.1814 69.9436
B6.A-Chr18 both 86.0625 5.65 97.1823 74.9427
B6.A-Chr19 both 75.2143 6.0401 87.1018 63.3267
B6.A-Chr2 both 86.75 6.442 99.4285 74.0715
B6.A-Chr3 both 79.9375 5.65 91.0573 68.8177
B6.A-Chr4 both 69.875 6.1027 81.8857 57.8643
B6.A-Chr5 both 64.875 5.65 75.9948 53.7552
B6.A-Chr6 both 94.5714 5.8483 106.0815 83.0614
B6.A-Chr7 both 66.5 6.0401 78.3875 54.6125
B6.A-Chr8 both 62.642 5.2507 72.9759 52.3082
B6.A-Chr9 both 66.25 6.1027 78.2607 54.2393
B6.A-ChrX both 69.8661 5.8483 81.3761 58.356
B6.A-ChrY both 76.5208 6.1027 88.5316 64.5101
C57BL/6J both 88.0714 6.0401 99.959 76.1839




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA