Phenotype measure

ID, description, units MPD:2924   ALT   alanine transaminase (plasma ALT)   [IU/L]
high-fat diet study
Data set, strains Paigen1   inbred   43 strains     sex: both     age: 15-19wks
Procedure metabolic panel
Ontology mappings


  STRAIN COMPARISON PLOT
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Paigen1 - alanine transaminase (plasma ALT)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested43 strains40 strains
Mean of the strain means154   IU/L 189   IU/L
Median of the strain means132   IU/L 181   IU/L
SD of the strain means± 129 ± 84.8
Coefficient of variation (CV)0.838 0.448
Min–max range of strain means17.3   –   813   IU/L 29.6   –   520   IU/L
Mean sample size per strain8.5   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 402726.876 402726.876 50.3473 < 0.0001
strain 39 2859389.7503 73317.6859 9.1659 < 0.0001
sex:strain 39 1365625.9243 35016.0493 4.3776 < 0.0001
Residuals 607 4855376.0986 7998.9722


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 55.9 29.0   7 11.0 0.519 38.0, 120.0 -0.76
129S1/SvImJ m 76.1 27.8   9 9.26 0.365 48.0, 129.0 -1.33
A/J f 813.0 341.0   8 120.0 0.419 378.0, 1431.0 5.09
AKR/J f 136.0 58.6   10 18.5 0.429 47.0, 224.0 -0.14
AKR/J m 161.0 65.6   9 21.9 0.407 49.0, 255.0 -0.33
BALB/cJ f 106.0 16.2   10 5.13 0.154 84.0, 136.0 -0.37
BALB/cJ m 280.0 112.0   9 37.3 0.4 171.0, 534.0 1.07
BPH/2J f 77.5 90.8   10 28.7 1.17 7.0, 243.0 -0.59
BPH/2J m 135.0 82.9   8 29.3 0.614 21.0, 273.0 -0.64
BPL/1J f 254.0 67.3   10 21.3 0.265 152.0, 362.0 0.77
BPL/1J m 257.0 81.4   10 25.7 0.317 101.0, 362.0 0.8
BPN/3J f 68.6 29.4   7 11.1 0.429 36.0, 123.0 -0.66
BPN/3J m 93.9 26.6   9 8.86 0.283 62.0, 137.0 -1.12
BTBR T+ Itpr3tf/J f 37.8 8.21   8 2.9 0.217 26.0, 52.0 -0.9
BTBR T+ Itpr3tf/J m 85.1 40.4   14 10.8 0.475 29.0, 169.0 -1.23
C3H/HeJ f 127.0 43.8   8 15.5 0.345 68.0, 190.0 -0.21
C3H/HeJ m 245.0 166.0   10 52.5 0.677 46.0, 504.0 0.66
C57BL/10J f 61.3 8.47   9 2.82 0.138 45.0, 75.0 -0.72
C57BL/10J m 286.0 82.5   5 36.9 0.288 208.0, 414.0 1.14
C57BL/6J f 56.5 13.9   15 3.59 0.246 36.0, 84.0 -0.76
C57BL/6J m 127.0 47.1   14 12.6 0.37 61.0, 214.0 -0.73
C57BLKS/J f 151.0 126.0   27 24.3 0.833 24.0, 394.0 -0.03
C57BLKS/J m 147.0 102.0   15 26.3 0.691 41.0, 362.0 -0.5
C57BR/cdJ f 178.0 57.0   7 21.5 0.321 114.0, 248.0 0.18
C57BR/cdJ m 147.0 39.4   10 12.4 0.268 97.0, 212.0 -0.5
C57L/J f 161.0 86.1   7 32.5 0.535 70.0, 290.0 0.05
C57L/J m 256.0 92.3   8 32.6 0.361 147.0, 385.0 0.79
C58/J f 237.0 76.7   9 25.6 0.323 161.0, 370.0 0.64
C58/J m 226.0 66.6   9 22.2 0.295 161.0, 343.0 0.43
CAST/EiJ f 168.0 65.8   7 24.9 0.392 97.0, 297.0 0.11
CAST/EiJ m 144.0 30.8   9 10.3 0.214 86.0, 187.0 -0.53
CBA/J f 58.2 13.7   9 4.57 0.236 45.0, 84.0 -0.74
CBA/J m 217.0 122.0   10 38.5 0.561 87.0, 420.0 0.33
CE/J f 183.0 62.3   9 20.8 0.34 113.0, 282.0 0.22
CE/J m 204.0 41.5   5 18.6 0.204 148.0, 247.0 0.17
CZECHII/EiJ f 99.0 24.7   6 10.1 0.249 52.0, 122.0 -0.43
CZECHII/EiJ m 198.0 145.0   7 54.9 0.734 38.0, 442.0 0.1
DBA/1J f 132.0 39.9   7 15.1 0.302 83.0, 200.0 -0.17
DBA/1J m 296.0 46.0   3 26.6 0.156 250.0, 342.0 1.26
DBA/2J f 43.7 21.5   10 6.79 0.492 21.0, 81.0 -0.86
DBA/2J m 93.5 50.3   6 20.5 0.538 48.0, 178.0 -1.13
FVB/NJ f 103.0 22.7   9 7.57 0.22 74.0, 137.0 -0.4
FVB/NJ m 182.0 81.6   3 47.1 0.449 95.0, 257.0 -0.09
I/LnJ f 119.0 37.6   10 11.9 0.317 67.0, 188.0 -0.27
I/LnJ m 219.0 179.0   8 63.3 0.819 84.0, 576.0 0.35
KK/HlJ f 86.8 29.8   9 9.94 0.344 60.0, 160.0 -0.52
KK/HlJ m 223.0 46.6   7 17.6 0.209 173.0, 311.0 0.4
LP/J f 215.0 37.9   5 17.0 0.177 166.0, 263.0 0.47
LP/J m 171.0 83.3   7 31.5 0.486 80.0, 279.0 -0.22
MOLF/EiJ f 189.0 214.0   6 87.2 1.13 20.0, 550.0 0.27
MOLF/EiJ m 260.0 357.0   8 126.0 1.37 36.0, 846.0 0.83
NOD/ShiLtJ f 17.3 7.09   10 2.24 0.41 5.0, 25.0 -1.06
NOD/ShiLtJ m 298.0 179.0   7 67.6 0.6 131.0, 606.0 1.28
NON/ShiLtJ f 95.9 11.3   9 3.77 0.118 78.0, 109.0 -0.45
NON/ShiLtJ m 95.5 15.7   8 5.55 0.164 70.0, 118.0 -1.11
NZB/BlNJ f 214.0 164.0   11 49.6 0.767 12.0, 540.0 0.46
NZB/BlNJ m 196.0 24.9   7 9.41 0.127 160.0, 224.0 0.08
NZW/LacJ f 126.0 33.7   7 12.7 0.268 62.0, 161.0 -0.22
NZW/LacJ m 102.0 45.2   10 14.3 0.445 36.0, 170.0 -1.03
PERA/EiJ f 154.0 55.7   7 21.1 0.361 82.0, 257.0 0.0
PERA/EiJ m 180.0 53.7   4 26.8 0.298 112.0, 233.0 -0.11
P/J f 143.0 32.5   10 10.3 0.228 105.0, 203.0 -0.09
P/J m 156.0 87.7   9 29.2 0.564 57.0, 284.0 -0.39
PL/J f 359.0 83.6   3 48.3 0.233 264.0, 420.0 1.58
RBF/DnJ f 308.0 71.9   10 22.7 0.234 201.0, 409.0 1.19
RBF/DnJ m 202.0 80.2   9 26.7 0.397 84.0, 336.0 0.15
RF/J f 124.0 31.9   10 10.1 0.256 76.0, 185.0 -0.23
RF/J m 179.0 52.4   6 21.4 0.293 128.0, 243.0 -0.12
RIIIS/J f 251.0 86.3   10 27.3 0.343 111.0, 394.0 0.75
RIIIS/J m 214.0 59.5   8 21.0 0.278 134.0, 288.0 0.29
SEA/GnJ f 31.6 6.61   8 2.34 0.209 24.0, 42.0 -0.95
SEA/GnJ m 29.6 12.3   9 4.09 0.415 12.0, 48.0 -1.88
SJL/J f 197.0 68.4   8 24.2 0.347 135.0, 338.0 0.33
SJL/J m 180.0 52.3   9 17.4 0.291 114.0, 268.0 -0.11
SM/J f 56.3 12.3   7 4.65 0.219 46.0, 80.0 -0.76
SM/J m 115.0 74.7   6 30.5 0.648 42.0, 246.0 -0.88
SPRET/EiJ f 200.0 119.0   7 45.0 0.596 48.0, 367.0 0.35
SPRET/EiJ m 144.0 74.7   5 33.4 0.519 75.0, 251.0 -0.53
SWR/J f 248.0 39.1   9 13.0 0.158 199.0, 320.0 0.72
SWR/J m 230.0 77.7   8 27.5 0.338 119.0, 313.0 0.48
WSB/EiJ f 162.0 74.8   7 28.3 0.461 94.0, 308.0 0.06
WSB/EiJ m 520.0 231.0   9 76.9 0.443 79.0, 860.0 3.9
YBR/EiJ f 32.8 3.49   5 1.56 0.106 28.0, 37.0 -0.94


  LEAST SQUARES MEANS (ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 55.8571 33.804 122.2441 0.0
129S1/SvImJ m 76.1111 29.8123 134.6589 17.5633
AKR/J f 136.5 28.2825 192.0433 80.9567
AKR/J m 161.3333 29.8123 219.8812 102.7855
BALB/cJ f 105.5 28.2825 161.0433 49.9567
BALB/cJ m 280.1111 29.8123 338.6589 221.5633
BPH/2J f 77.5 28.2825 133.0433 21.9567
BPH/2J m 135.125 31.6207 197.2243 73.0257
BPL/1J f 254.2 28.2825 309.7433 198.6567
BPL/1J m 256.8 28.2825 312.3433 201.2567
BPN/3J f 68.5714 33.804 134.9584 2.1844
BPN/3J m 93.8889 29.8123 152.4367 35.3411
BTBR T+ Itpr3tf/J f 37.75 31.6207 99.8493 0.0
BTBR T+ Itpr3tf/J m 85.1429 23.903 132.0855 38.2002
C3H/HeJ f 126.875 31.6207 188.9743 64.7757
C3H/HeJ m 245.4 28.2825 300.9433 189.8567
C57BL/10J f 61.3333 29.8123 119.8812 2.7855
C57BL/10J m 286.0 39.9974 364.5501 207.4499
C57BL/6J f 56.4667 23.0925 101.8176 11.1157
C57BL/6J m 127.1429 23.903 174.0855 80.2002
C57BLKS/J f 151.4815 17.2122 185.2841 117.6789
C57BLKS/J m 147.4 23.0925 192.7509 102.0491
C57BR/cdJ f 177.5714 33.804 243.9584 111.1844
C57BR/cdJ m 146.8 28.2825 202.3433 91.2567
C57L/J f 160.7143 33.804 227.1013 94.3273
C57L/J m 256.0 31.6207 318.0993 193.9007
C58/J f 237.3333 29.8123 295.8812 178.7855
C58/J m 225.5556 29.8123 284.1034 167.0077
CAST/EiJ f 167.8571 33.804 234.2441 101.4702
CAST/EiJ m 144.3333 29.8123 202.8812 85.7855
CBA/J f 58.2222 29.8123 116.77 0.0
CBA/J m 216.7 28.2825 272.2433 161.1567
CE/J f 182.8889 29.8123 241.4367 124.3411
CE/J m 203.8 39.9974 282.3501 125.2499
CZECHII/EiJ f 99.0 36.5125 170.7061 27.2939
CZECHII/EiJ m 197.8571 33.804 264.2441 131.4702
DBA/1J f 131.8571 33.804 198.2441 65.4702
DBA/1J m 295.6667 51.6365 397.0745 194.2589
DBA/2J f 43.7 28.2825 99.2433 0.0
DBA/2J m 93.5 36.5125 165.2061 21.7939
FVB/NJ f 103.1111 29.8123 161.6589 44.5633
FVB/NJ m 181.6667 51.6365 283.0745 80.2589
I/LnJ f 118.7 28.2825 174.2433 63.1567
I/LnJ m 218.625 31.6207 280.7243 156.5257
KK/HlJ f 86.7778 29.8123 145.3256 28.23
KK/HlJ m 222.7143 33.804 289.1013 156.3273
LP/J f 214.8 39.9974 293.3501 136.2499
LP/J m 171.2857 33.804 237.6727 104.8987
MOLF/EiJ f 188.8333 36.5125 260.5395 117.1272
MOLF/EiJ m 259.75 31.6207 321.8493 197.6507
NOD/ShiLtJ f 17.3 28.2825 72.8433 0.0
NOD/ShiLtJ m 298.1429 33.804 364.5298 231.7559
NON/ShiLtJ f 95.8889 29.8123 154.4367 37.3411
NON/ShiLtJ m 95.5 31.6207 157.5993 33.4007
NZB/BlNJ f 214.4545 26.9663 267.413 161.496
NZB/BlNJ m 196.4286 33.804 262.8156 130.0416
NZW/LacJ f 125.7143 33.804 192.1013 59.3273
NZW/LacJ m 101.6 28.2825 157.1433 46.0567
PERA/EiJ f 154.4286 33.804 220.8156 88.0416
PERA/EiJ m 180.0 44.7185 267.8217 92.1783
P/J f 142.8 28.2825 198.3433 87.2567
P/J m 155.5556 29.8123 214.1034 97.0077
RBF/DnJ f 307.7 28.2825 363.2433 252.1567
RBF/DnJ m 201.8889 29.8123 260.4367 143.3411
RF/J f 124.5 28.2825 180.0433 68.9567
RF/J m 178.6667 36.5125 250.3728 106.9605
RIIIS/J f 251.3 28.2825 306.8433 195.7567
RIIIS/J m 214.0 31.6207 276.0993 151.9007
SEA/GnJ f 31.625 31.6207 93.7243 0.0
SEA/GnJ m 29.5556 29.8123 88.1034 0.0
SJL/J f 197.375 31.6207 259.4743 135.2757
SJL/J m 179.8889 29.8123 238.4367 121.3411
SM/J f 56.2857 33.804 122.6727 0.0
SM/J m 115.3333 36.5125 187.0395 43.6272
SPRET/EiJ f 199.7143 33.804 266.1013 133.3273
SPRET/EiJ m 143.8 39.9974 222.3501 65.2499
SWR/J f 247.6667 29.8123 306.2145 189.1188
SWR/J m 229.75 31.6207 291.8493 167.6507
WSB/EiJ f 162.1429 33.804 228.5298 95.7559
WSB/EiJ m 520.0 29.8123 578.5478 461.4522


  LEAST SQUARES MEANS (ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 65.9841 22.536 110.2421 21.7261
AKR/J both 148.9167 20.5467 189.268 108.5654
BALB/cJ both 192.8056 20.5467 233.1569 152.4543
BPH/2J both 106.3125 21.2118 147.97 64.655
BPL/1J both 255.5 19.9987 294.7751 216.2249
BPN/3J both 81.2302 22.536 125.4882 36.9722
BTBR T+ Itpr3tf/J both 61.4464 19.8194 100.3693 22.5236
C3H/HeJ both 186.1375 21.2118 227.795 144.48
C57BL/10J both 173.6667 24.9428 222.6513 124.682
C57BL/6J both 91.8048 16.6179 124.4403 59.1692
C57BLKS/J both 149.4407 14.4007 177.722 121.1595
C57BR/cdJ both 162.1857 22.0375 205.4647 118.9067
C57L/J both 208.3571 23.144 253.8092 162.9051
C58/J both 231.4444 21.0805 272.844 190.0449
CAST/EiJ both 156.0952 22.536 200.3532 111.8372
CBA/J both 137.4611 20.5467 177.8124 97.1098
CE/J both 193.3444 24.9428 242.3291 144.3598
CZECHII/EiJ both 148.4286 24.8791 197.2881 99.5691
DBA/1J both 213.7619 30.8587 274.3647 153.1592
DBA/2J both 68.6 23.0925 113.9509 23.2491
FVB/NJ both 142.3889 29.8123 200.9367 83.8411
I/LnJ both 168.6625 21.2118 210.32 127.005
KK/HlJ both 154.746 22.536 199.004 110.488
LP/J both 193.0429 26.1845 244.466 141.6197
MOLF/EiJ both 224.2917 24.1507 271.7208 176.8625
NOD/ShiLtJ both 157.7214 22.0375 201.0005 114.4424
NON/ShiLtJ both 95.6944 21.7293 138.3681 53.0208
NZB/BlNJ both 205.4416 21.6211 247.9028 162.9803
NZW/LacJ both 113.6571 22.0375 156.9362 70.3781
PERA/EiJ both 167.2143 28.0288 222.2595 112.1691
P/J both 149.1778 20.5467 189.5291 108.8265
RBF/DnJ both 254.7944 20.5467 295.1457 214.4431
RF/J both 151.5833 23.0925 196.9343 106.2324
RIIIS/J both 232.65 21.2118 274.3075 190.9925
SEA/GnJ both 30.5903 21.7293 73.264 0.0
SJL/J both 188.6319 21.7293 231.3056 145.9583
SM/J both 85.8095 24.8791 134.669 36.95
SPRET/EiJ both 171.7571 26.1845 223.1803 120.334
SWR/J both 238.7083 21.7293 281.382 196.0346
WSB/EiJ both 341.0714 22.536 385.3294 296.8134