Lake1: Multi-system analysis of mouse physiology, C57BL/6J-Chr#A/J/NaJ chromosome substitution panel (2005)

Lake J, Donahue L, Davisson MT

       
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Participants Jeffrey Lake       The Jackson Laboratory Bar Harbor, ME
Leah Rae Donahue       The Jackson Laboratory Bar Harbor, ME
Muriel T Davisson       The Jackson Laboratory Bar Harbor, ME
ContactJeffrey Lake     jpl@jax.org
Part of a series: • physiology   (this project) Lake1
• SHIRPA   see Lake2
• behavior   see Lake3
Project type Phenotype strain survey data set
MPD identifiersLake1     MPD:199
Data changelog 1 update/correction.       Initial release date: 10/2007.
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Animals were evaluated in these areas: hematology, blood chemistry, lung function, blood pressure and pulse, and electrocardiogram.

Summary of procedures that were conducted
• complete blood count Hematology.
• metabolic panel Glucose, bilirubin, aspartate transaminase (plasma). 4h fast.
• lipid profile Cholesterol, HDL, triglycerides, fatty acids. 4h fast, plasma.
• ECG Heart rate and wave intervals. Conscious.
• tail cuff Heart rate and blood pressure. Conscious mice.
Mice: B6.A consomic w/par   23 strains   ♀♂   age 7-11wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Lake1 19901 complete blood count (none) white blood cell count (WBC; per volume x 103)   [n/µL]  WBC B6.A consomic w/par 23 both 7wks N=8
    Lake1 19902 complete blood count (none) red blood cell count (RBC; per volume x 106)   [n/µL]  RBC B6.A consomic w/par 23 both 7wks N=8
    Lake1 19903 complete blood count (none) neutrophil differential (percent of total WBC)   [%]  pct_NEUT B6.A consomic w/par 23 both 7wks N=8
    Lake1 19904 complete blood count (none) lymphocyte differential (percent of total WBC)   [%]  pct_LYM B6.A consomic w/par 23 both 7wks N=8
    Lake1 19905 complete blood count (none) monocyte differential (percent of total WBC)   [%]  pct_MONO B6.A consomic w/par 23 both 7wks N=8
    Lake1 19906 complete blood count (none) eosinophil differential (percent of total WBC)   [%]  pct_EOS B6.A consomic w/par 23 both 7wks N=8
    Lake1 19907 complete blood count (none) large unstained cell differential (percent of total WBC)   [%]  pct_LUC B6.A consomic w/par 23 both 7wks N=8
    Lake1 19908 complete blood count (none) basophil differential (percent of total WBC)   [%]  pct_BASO B6.A consomic w/par 23 both 7wks N=8
    Lake1 19909 complete blood count (none) reticulocyte count (Retic; units per volume x 109)   [n/L]  reticulocytes B6.A consomic w/par 23 both 7wks N=8
    Lake1 19910 complete blood count (none) measured hemoglobin (HGB)   [g/dL]  mHGB B6.A consomic w/par 23 both 7wks N=8
    Lake1 19911 complete blood count (none) calculated hemoglobin (HGB)   [g/dL]  cHGB B6.A consomic w/par 23 both 7wks N=8
    Lake1 19912 complete blood count (none) hematocrit (HCT)   [%]  HCT B6.A consomic w/par 23 both 7wks N=8
    Lake1 19913 complete blood count (none) mean RBC corpuscular volume (MCV)   [fL]  MCV B6.A consomic w/par 23 both 7wks N=8
    Lake1 19914 complete blood count (none) mean RBC corpuscular hemoglobin content (MCH)   [pg]  MCH B6.A consomic w/par 23 both 7wks N=8
    Lake1 19915 complete blood count (none) mean RBC corpuscular hemoglobin concentration (MCHC)   [g/dL]  MCHC B6.A consomic w/par 23 both 7wks N=8
    Lake1 19916 complete blood count (none) RBC corpuscular hemoglobin concentration mean (CHCM)   [g/dL]  CHCM B6.A consomic w/par 23 both 7wks N=8
    Lake1 19917 complete blood count (none) RBC corpuscular distribution width (RDW)   [%]  RDW B6.A consomic w/par 23 both 7wks N=8
    Lake1 19918 complete blood count (none) hemoglobin concentration distribution width (HDW)   [g/dL]  HDW B6.A consomic w/par 23 both 7wks N=8
    Lake1 19919 complete blood count (none) platelet count (PLT; units per volume x 103)   [n/µL]  PLT B6.A consomic w/par 23 both 7wks N=8
    Lake1 19920 complete blood count (none) mean platelet volume (MPV)   [fL]  MPV B6.A consomic w/par 23 both 7wks N=8
    Lake1 19925 lipid profile (none) total cholesterol (plasma CHOL)   [mg/dL]  CHOL B6.A consomic w/par 23 both 8wks N=8
    Lake1 19926 lipid profile (none) HDL cholesterol (plasma HDL)   [mg/dL]  HDL B6.A consomic w/par 23 both 8wks N=8
    Lake1 19927 metabolic panel (none) glucose (plasma GLU, 4h fast)   [mg/dL]  GLU B6.A consomic w/par 23 both 8wks N=8
    Lake1 19928 lipid profile (none) triglycerides (plasma TG, 4h fast)   [mg/dL]  TG B6.A consomic w/par 23 both 8wks N=8
    Lake1 19929 metabolic panel (none) aspartate transaminase (plasma AST)   [mg/dL]  AST B6.A consomic w/par 23 both 8wks N=7
    Lake1 19930 lipid profile (none) total fatty acids (plasma TFA)   [mg/dL]  TFA B6.A consomic w/par 23 both 8wks N=8
    Lake1 19931 metabolic panel (none) total bilirubin (plasma TBIL)   [mg/dL]  TBIL B6.A consomic w/par 23 both 8wks N=7
    Lake1 19940 ECG (none) heart rate   [n/min]  HR B6.A consomic w/par 23 both 11wks N=8
    Lake1 19941 ECG (none) interval between beginning and end of QRS complex   [ms]  QRS B6.A consomic w/par 23 both 11wks N=8
    Lake1 19942 ECG (none) interval between peak of P-wave to R-wave (PR)   [ms]  PR B6.A consomic w/par 23 both 11wks N=8
    Lake1 19943 ECG (none) interval between peak of P-wave to Q-wave (PQ)   [ms]  PQ B6.A consomic w/par 23 both 11wks N=8
    Lake1 19944 ECG (none) interval between peak of Q-wave to end of T-wave (QT)   [ms]  QT B6.A consomic w/par 23 both 11wks N=8
    Lake1 19945 ECG (none) rate-corrected QT interval   [ms]  QTc B6.A consomic w/par 23 both 11wks N=8
    Lake1 19946 ECG (none) difference between smallest and largest QT interval   [ms]  QT_Dis B6.A consomic w/par 23 both 11wks N=8
    Lake1 19947 ECG (none) difference between smallest and largest rate-corrected QT interval   [ms]  QTc_Dis B6.A consomic w/par 23 both 11wks N=8
    Lake1 19948 ECG (none) interval between R-waves (RR)   [ms]  RR B6.A consomic w/par 23 both 11wks N=8
    Lake1 19949 tail cuff (none) heart rate variability   [n/min]  HRV B6.A consomic w/par 23 both 11wks N=8
    Lake1 19950 tail cuff (none) heart rate coefficient of variance   [%]  HR_cv B6.A consomic w/par 23 both 11wks N=8
    Lake1 19951 tail cuff (none) pulse rate   [n/min]  pulse B6.A consomic w/par 23 both 10wks N=8
    Lake1 19952 tail cuff (none) pulse rate variability across tests   [n/min]  pulse_sd B6.A consomic w/par 23 both 10wks N=8
    Lake1 19953 tail cuff (none) systolic blood pressure   [mmHg]  bp B6.A consomic w/par 23 both 10wks N=8
    Lake1 19980 complete blood count (none) neutrophil count (NEUT; units per volume x 103)   [n/µL]  NEUT B6.A consomic w/par 23 both 7wks N=8
    Lake1 19981 complete blood count (none) lymphocyte count (LYMP; units per volume x 103)   [n/µL]  LYM B6.A consomic w/par 23 both 7wks N=8
    Lake1 19982 complete blood count (none) monocyte count (MONO; units per volume x 103)   [n/µL]  MONO B6.A consomic w/par 23 both 7wks N=8
    Lake1 19983 complete blood count (none) eosinophil count (EOS; units per volume x 103)   [n/µL]  EOS B6.A consomic w/par 23 both 7wks N=8
    Lake1 19984 complete blood count (none) large unstained cells count (LUC; units per volume x 103)   [n/µL]  LUC B6.A consomic w/par 23 both 7wks N=8
    Lake1 19985 complete blood count (none) basophil count (BASO; units per volume x 103)   [n/µL]  BASO B6.A consomic w/par 23 both 7wks N=8
    Lake1 19986 complete blood count (none) reticulocyte differential (percent of total RBC)   [%]  pct_Retic B6.A consomic w/par 23 both 7wks N=8
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