MPD: Data set: Lake1

Animals were evaluated in these areas: hematology, blood chemistry, lung function, blood pressure and pulse, and electrocardiogram.

Procedures conducted:

• complete blood count		Hematology.
• metabolic panel		Glucose, bilirubin, aspartate transaminase (plasma). 4h fast.
• lipid profile		Cholesterol, HDL, triglycerides, fatty acids. 4h fast, plasma.
• ECG		Heart rate and wave intervals. Conscious.
• tail cuff		Heart rate and blood pressure. Conscious mice.

Lake1 downloads
• Download Lake1 project data set animal data, as uploaded
• Download Lake1 animal data matrix with factor-related expansion applied as necessary
• Download Lake1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Lake1 measures:

MA:0000010 cardiovascular system
MA:0000059 blood
MA:0000072 heart
MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0000188 abnormal circulating glucose level
MP:0000203 abnormal circulating aspartate transaminase level
MP:0000217 abnormal leukocyte cell number
MP:0000226 abnormal mean corpuscular volume
MP:0000230 abnormal systemic arterial blood pressure
MP:0000717 abnormal lymphocyte cell number
MP:0001553 abnormal circulating free fatty acids level
MP:0001569 abnormal circulating bilirubin level
MP:0001586 abnormal erythrocyte cell number
MP:0001588 abnormal hemoglobin
MP:0001589 abnormal mean corpuscular hemoglobin
MP:0001629 abnormal heart rate
MP:0002586 abnormal platelet volume
MP:0002596 abnormal hematocrit
MP:0002602 abnormal eosinophil cell number
MP:0003898 abnormal QRS complex
MP:0003899 abnormal QT interval
MP:0003901 abnormal PR interval
MP:0005640 abnormal mean corpuscular hemoglobin concentration
MP:0008849 abnormal hemoglobin concentration distribution width
MP:0010066 abnormal red blood cell distribution width
MP:0010504 abnormal RR interval
MP:0010695 abnormal blood pressure regulation
MP:0011898 abnormal platelet cell number
MP:0011913 abnormal reticulocyte cell number
MP:0011918 abnormal PQ interval
MP:0011969 abnormal circulating triglyceride level
MP:0012360 abnormal large unstained cell number
MP:0012397 abnormal nucleated erythrocyte cell number
MP:0012440 abnormal neutrophil cell number
MP:0012441 abnormal monocyte cell number
MP:0012442 abnormal basophil cell number
VT:0000180 blood cholesterol amount
VT:0000183 blood pressure trait
VT:0000184 blood HDL cholesterol amount
VT:0000188 blood glucose amount
VT:0000203 blood aspartate transaminase amount
VT:0000217 leukocyte quantity
VT:0000222 neutrophil quantity
VT:0000223 monocyte quantity
VT:0000231 heart excitatory physiology trait
VT:0000248 erythrocyte size trait
VT:0000717 lymphocyte quantity
VT:0001553 blood free fatty acid amount
VT:0001569 blood bilirubin amount
VT:0001586 erythrocyte quantity
VT:0001588 blood hemoglobin amount
VT:0002447 erythrocyte morphology trait
VT:0002602 eosinophil quantity
VT:0002607 basophil quantity
VT:0002644 blood triglyceride amount
VT:0003135 reticulocyte quantity
VT:0003179 platelet quantity
VT:0004152 blood iron amount
VT:0010457 platelet size trait
VT:2000009 heart pumping trait

Investigators	Jeffrey Lake The Jackson Laboratory, Bar Harbor, ME Leah Rae Donahue The Jackson Laboratory, Bar Harbor, ME Muriel T Davisson The Jackson Laboratory, Bar Harbor, ME
Contact	Jeffrey Lake jpl@jax.org
Part of a series:	• physiology (this project) Lake1 • SHIRPA see Lake2 • behavior see Lake3
Project type	Phenotype strain survey data set
MPD identifiers	Lake1 MPD:199
Data changelog	1 update/correction. Initial release date: 10/2007.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Lake1:1	Lake1	complete blood count	(none)	white blood cell count (WBC; per volume x 10³) [n/µL] WBC 19901	B6.A consomic w/par	23	both	7wks	N=8

Lake1:2	Lake1	complete blood count	(none)	red blood cell count (RBC; per volume x 10⁶) [n/µL] RBC 19902	B6.A consomic w/par	23	both	7wks	N=8

Lake1:3	Lake1	complete blood count	(none)	neutrophil differential (NEUT; percentage of total WBC) [%] pct_NEUT 19903	B6.A consomic w/par	23	both	7wks	N=8

Lake1:4	Lake1	complete blood count	(none)	lymphocyte differential (LYM; percentage of total WBC) [%] pct_LYM 19904	B6.A consomic w/par	23	both	7wks	N=8

Lake1:5	Lake1	complete blood count	(none)	monocyte differential (MONO; percentage of total WBC) [%] pct_MONO 19905	B6.A consomic w/par	23	both	7wks	N=8

Lake1:6	Lake1	complete blood count	(none)	eosinophil differential (EOS; percentage of total WBC) [%] pct_EOS 19906	B6.A consomic w/par	23	both	7wks	N=8

Lake1:7	Lake1	complete blood count	(none)	large unstained cell differential (LUC; percentage of total WBC) [%] pct_LUC 19907	B6.A consomic w/par	23	both	7wks	N=8

Lake1:8	Lake1	complete blood count	(none)	basophil differential (BASO; percentage of total WBC) [%] pct_BASO 19908	B6.A consomic w/par	23	both	7wks	N=8

Lake1:9	Lake1	complete blood count	(none)	reticulocyte count (Retic; units per volume x 10⁹) [n/L] reticulocytes 19909	B6.A consomic w/par	23	both	7wks	N=8

Lake1:10	Lake1	complete blood count	(none)	measured hemoglobin (HGB) [g/dL] mHGB 19910	B6.A consomic w/par	23	both	7wks	N=8

Lake1:11	Lake1	complete blood count	(none)	calculated hemoglobin (HGB) [g/dL] cHGB 19911	B6.A consomic w/par	23	both	7wks	N=8

Lake1:12	Lake1	complete blood count	(none)	hematocrit (HCT) [%] HCT 19912	B6.A consomic w/par	23	both	7wks	N=8

Lake1:13	Lake1	complete blood count	(none)	mean RBC corpuscular volume (MCV) [fL] MCV 19913	B6.A consomic w/par	23	both	7wks	N=8

Lake1:14	Lake1	complete blood count	(none)	mean RBC corpuscular hemoglobin content (MCH) [pg] MCH 19914	B6.A consomic w/par	23	both	7wks	N=8

Lake1:15	Lake1	complete blood count	(none)	mean RBC corpuscular hemoglobin concentration (MCHC) [g/dL] MCHC 19915	B6.A consomic w/par	23	both	7wks	N=8

Lake1:16	Lake1	complete blood count	(none)	RBC corpuscular hemoglobin concentration mean (CHCM) [g/dL] CHCM 19916	B6.A consomic w/par	23	both	7wks	N=8

Lake1:17	Lake1	complete blood count	(none)	RBC corpuscular distribution width (RDW) [%] RDW 19917	B6.A consomic w/par	23	both	7wks	N=8

Lake1:18	Lake1	complete blood count	(none)	hemoglobin concentration distribution width (HDW) [g/dL] HDW 19918	B6.A consomic w/par	23	both	7wks	N=8

Lake1:19	Lake1	complete blood count	(none)	platelet count (PLT; units per volume x 10³) [n/µL] PLT 19919	B6.A consomic w/par	23	both	7wks	N=8

Lake1:20	Lake1	complete blood count	(none)	mean platelet volume (MPV) [fL] MPV 19920	B6.A consomic w/par	23	both	7wks	N=8

Lake1:25	Lake1	lipid profile	(none)	total cholesterol (plasma CHOL) [mg/dL] CHOL 19925	B6.A consomic w/par	23	both	8wks	N=8

Lake1:26	Lake1	lipid profile	(none)	HDL cholesterol (plasma HDL) [mg/dL] HDL 19926	B6.A consomic w/par	23	both	8wks	N=8

Lake1:27	Lake1	metabolic panel	(none)	glucose (plasma GLU, 4h fast) [mg/dL] GLU 19927	B6.A consomic w/par	23	both	8wks	N=8

Lake1:28	Lake1	lipid profile	(none)	triglycerides (plasma TG, 4h fast) [mg/dL] TG 19928	B6.A consomic w/par	23	both	8wks	N=8

Lake1:29	Lake1	metabolic panel	(none)	aspartate transaminase (plasma AST) [mg/dL] AST 19929	B6.A consomic w/par	23	both	8wks	N=7

Lake1:30	Lake1	lipid profile	(none)	total fatty acids (plasma TFA) [mg/dL] TFA 19930	B6.A consomic w/par	23	both	8wks	N=8

Lake1:31	Lake1	metabolic panel	(none)	total bilirubin (plasma TBIL) [mg/dL] TBIL 19931	B6.A consomic w/par	23	both	8wks	N=7

Lake1:40	Lake1	ECG	(none)	heart rate [n/min] HR 19940	B6.A consomic w/par	23	both	11wks	N=8

Lake1:41	Lake1	ECG	(none)	interval between beginning and end of QRS complex [ms] QRS 19941	B6.A consomic w/par	23	both	11wks	N=8

Lake1:42	Lake1	ECG	(none)	interval between peak of P-wave to R-wave (PR) [ms] PR 19942	B6.A consomic w/par	23	both	11wks	N=8

Lake1:43	Lake1	ECG	(none)	interval between peak of P-wave to Q-wave (PQ) [ms] PQ 19943	B6.A consomic w/par	23	both	11wks	N=8

Lake1:44	Lake1	ECG	(none)	interval between peak of Q-wave to end of T-wave (QT) [ms] QT 19944	B6.A consomic w/par	23	both	11wks	N=8

Lake1:45	Lake1	ECG	(none)	rate-corrected QT interval [ms] QTc 19945	B6.A consomic w/par	23	both	11wks	N=8

Lake1:46	Lake1	ECG	(none)	difference between smallest and largest QT interval [ms] QT_Dis 19946	B6.A consomic w/par	23	both	11wks	N=8

Lake1:47	Lake1	ECG	(none)	difference between smallest and largest rate-corrected QT interval [ms] QTc_Dis 19947	B6.A consomic w/par	23	both	11wks	N=8

Lake1:48	Lake1	ECG	(none)	interval between R-waves (RR) [ms] RR 19948	B6.A consomic w/par	23	both	11wks	N=8

Lake1:49	Lake1	tail cuff	(none)	heart rate variability [n/min] HRV 19949	B6.A consomic w/par	23	both	11wks	N=8

Lake1:50	Lake1	tail cuff	(none)	heart rate coefficient of variance [%] HR_cv 19950	B6.A consomic w/par	23	both	11wks	N=8

Lake1:51	Lake1	tail cuff	(none)	pulse rate [n/min] pulse 19951	B6.A consomic w/par	23	both	10wks	N=8

Lake1:52	Lake1	tail cuff	(none)	pulse rate variability across tests [n/min] pulse_sd 19952	B6.A consomic w/par	23	both	10wks	N=8

Lake1:53	Lake1	tail cuff	(none)	systolic blood pressure [mmHg] bp 19953	B6.A consomic w/par	23	both	10wks	N=8

Lake1:54	Lake1	tail cuff	(none)	systolic blood pressure variability across tests (local parameter) [mmHg] bp_sd 19954	B6.A consomic w/par	23	both	10wks	N=8

Lake1:80	Lake1	complete blood count	(none)	neutrophil count (NEUT; units per volume x 10³) [n/µL] NEUT 19980	B6.A consomic w/par	23	both	7wks	N=8

Lake1:81	Lake1	complete blood count	(none)	lymphocyte count (LYMP; units per volume x 10³) [n/µL] LYM 19981	B6.A consomic w/par	23	both	7wks	N=8

Lake1:82	Lake1	complete blood count	(none)	monocyte count (MONO; units per volume x 10³) [n/µL] MONO 19982	B6.A consomic w/par	23	both	7wks	N=8

Lake1:83	Lake1	complete blood count	(none)	eosinophil count (EOS; units per volume x 10³) [n/µL] EOS 19983	B6.A consomic w/par	23	both	7wks	N=8

Lake1:84	Lake1	complete blood count	(none)	large unstained cells count (LUC; units per volume x 10³) [n/µL] LUC 19984	B6.A consomic w/par	23	both	7wks	N=8

Lake1:85	Lake1	complete blood count	(none)	basophil count (BASO; units per volume x 10³) [n/µL] BASO 19985	B6.A consomic w/par	23	both	7wks	N=8

Lake1:86	Lake1	complete blood count	(none)	reticulocyte differential (Retic; percentage of total RBC) [%] pct_Retic 19986	B6.A consomic w/par	23	both	7wks	N=8

Lake1: Multi-system analysis of mouse physiology, C57BL/6J-Chr#^A/J/NaJ chromosome substitution panel (2005)

Filter Table Results

Lake1: Multi-system analysis of mouse physiology, C57BL/6J-Chr#A/J/NaJ chromosome substitution panel (2005)

Filter Table Results

Lake1: Multi-system analysis of mouse physiology, C57BL/6J-Chr#^A/J/NaJ chromosome substitution panel (2005)